CAS: 57477-39-1; 3-(1-Methylpiperidin-4-yl)-1H-Indol-5-Ol

该化合物是一种属于异极化合物类别的化学化合物,其特点是含有六人组成的苯环的双环结构,与五人组成的含氮火花环结合.该化合物具有管道性,有助于其潜在的生物活动,特别是在药理学领域.在无球环的5位置上存在氢化物组(OH),表明它可能具有氢结合等特性,从而影响其溶解性和再活性.此外,管状环上的甲基组可能影响到化合物的脂性及其与生物目标的相互作用.

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上下游产品

CAS号111963-87-2 5-甲氧基-3-(1-甲基-4... | CAS号1953-54-4 5-羟基吲哚

合成工艺路线路线简述

    📜5-甲氧基-3-(1-甲基-4-哌啶基)吲哚置于水,Silica Gel,氨,Methanol-Dichloromethane,甲醇,Resin体系中,用 氢溴酸,溶剂黄146 作为反应溶剂,化学反应 104.0H,以to Provide 1.84 G (85%) Of The Title Compound,Which的收率获得产物3-(1-甲基-4-哌啶基)-1H-吲哚-5-醇
    参考文献:5-Ht1F Agonists
    标题:5-Ht1F Agonists
    摘要:本发明涉及式(I)的化合物:或其药物酸加盐;该化合物对哺乳动物中的5-Ht1F受体具有激活作用并抑制蛋白质渗出.

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    专利信息


    专利号:WO-9700244-A1
    优先权日:1995-06-19
    标题 :Process for parallel synthesis of a non-peptide library
    发明人：FRITZ JAMES E; KALDOR STEPHEN W
    权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
    摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

    专利号:CN-109422728-B
    优先权日:2017-08-27
    标题 :A class of azetidine derivatives and synthesis method thereof

    专利号:CN-109422728-A
    优先权日:2017-08-27
    标题:A class of azetidine derivatives and synthesis method thereof

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    主要参考文献


    1: Nelson PM, Harrod JS, Lamping KG. 5HT(2A) and 5HT(2B) receptors contribute to serotonin-induced vascular dysfunction in diabetes. Exp Diabetes Res. 2012;2012:398406. doi: 10.1155/2012/398406. Epub 2012 Dec 30.
    2: Klein MT, Teitler M. Distribution of 5-ht(1E) receptors in the mammalian brain and cerebral vasculature: an immunohistochemical and pharmacological study. Br J Pharmacol. 2012 Jun;166(4):1290-302. doi: 10.1111/j.1476-5381.2012.01868.x.
    3: Klein MT, Dukat M, Glennon RA, Teitler M. Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships. J Pharmacol Exp Ther. 2011 Jun;337(3):860-7. doi: 10.1124/jpet.111.179606. Epub 2011 Mar 21.

    合成参考文献


    参考文献:10.1371/journal.pone.0218897
    摘要:Miller TW, Amason JD, Garcin ED, Lamy L, Dranchak PK, Macarthur R, Braisted J, Rubin JS, Burgess TL, Farrell CL, Roberts DD, Inglese J. Quantitative high-throughput screening assays for the discovery and development of SIRPα-CD47 interaction inhibitors. PLoS ONE. 2019 Jul 05;14(7):e0218897. doi: 10.1371/journal.pone.0218897.
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