CAS: 540-59-0; 1,2-Dichloroethene

该化合物是一种无色,易燃的,有甜味的液体,是一种氯化碳氢化合物,化学公式C2H2Cl2,并被归类为挥发性有机化合物.该物质存在于两种几何异构体中:Cis和Trans,转异构体更加稳定和经常遇到. 1,2-二氯乙烯主要用作各种化学品生产的中间体,以及工业应用中的溶剂.它具有相对较低的沸点和高蒸气压力,导致其挥发性.该化合物已知对人类健康有害,其潜在影响包括呼吸刺激和接触时...

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欧盟法规

统一分类与标签压力设备指令-第1组危险流体ECHA物质欧盟气雾剂指令-标签制度工作场所安全标识要求ECHA物质C&L通报REACH预注册废弃物危险特性清单

上下游产品

CAS号127-18-4 四氯乙烯 | CAS号630-20-6 1,1,1,2-四氯乙烷 | CAS号76-01-7 五氯乙烷 | CAS号79-34-5 四氯乙烷 | CAS号74-86-2 乙炔 | CAS号79-00-5 1,1,2-三氯乙烷 | CAS号683-68-1 二溴二氯乙烷 | CAS号7572-29-4 二氯乙炔 | CAS号74-84-0 乙烷 | CAS号54509-73-8 ethene | CAS号460-16-2 1-氯-2-氟乙烯 | CAS号430-57-9 1,2-二氯氟乙烷 | CAS号354-23-4 1,2-二氯三氟乙烷 | CAS号431-06-1 1,2-二氯-1,2-二氟乙烷... | CAS号542-75-6 1,3-二氯丙烯 | CAS号75-09-2 二氯甲烷 | CAS号2504-64-5 1,2-二(三氯甲硅基)乙烷 | CAS号692-52-4 trichloro(2-tri... | CAS号4142-85-2 双(三氯硅基甲烷) | CAS号23010-00-6 1-CHLORO-3-METH...

合成工艺路线路线简述

    📜三氯乙烯 反应生成 1,2-二氯乙烯
    参考文献:Nicodemus,Journal Fur Praktische Chemie (Leipzig 1954),1911,Vol. <2>83,P. 316
    标题:Nicodemus,Journal Fur Praktische Chemie (Leipzig 1954),1911,Vol. <2>83,P. 316

    海关参考信息

    专利信息


    专利号:US-11926589-B2
    优先权日:2019-07-09
    标 题 :Process for the synthesis of non-racemic cyclohexenes
    发明人:REISMAN SARAH; ROMBOLA MICHAEL; LADD CAROLYN L; MCLAUGHLIN MARTIN JOHN; ZUEND STEPHAN; GOETZ ROLAND
    权利人:BASF CORP; CALIFORNIA INST OF TECHN
    摘要:This invention relates to a process for the synthesis of a non-racemic cyclohexene compound of formula (I) by a Diels-Alder reaction of a compound of formula (II) with a compound of formula (III) wherein R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and Y have the meanings as defined in the description in the presence of a catalyst comprising at least one m-valent metal cation M m+ wherein the metal M is selected from Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium 15 (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), Gallium (Ga) and Indium (In), and m is an integer of 1, 2 or 3, and a chiral ligand of the formula (IV) wherein R 10a , R 10b , R 10c , R 10d , R 10a′ , R 10b′ , R 10c′ , R 10d′ , Z and Z′ have the meanings as defined in the description.

    专利号:US-2008032964-A1
    优先权日:2006-04-10
    标题:Process for the synthesis of azetidinone
    发明人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    权利人:KANSAL VINOD K; AHMAD SUHAIL; MARIAPPAN SHANMUGAVEL; TYAGI BHUPENDRA; PERLMAN NURIT; LE PAIH JACQUES; ZANOTTI-GEROSA ANTONIO
    摘要:Provided are intermediates useful for the synthesis of hydroxyl-alkyl substituted azetidinones, processes of their preparation, and processes for the synthesis of certain hydroxyl-alkyl substituted azetidinones. Also provided are processes for the synthesis of 1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone, or ezetimibe.

    专利号:US-2012203004-A1
    优先权日:2009-08-13
    标题 :process for the synthesis of alkyl/aralkyl (2s)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof: key intermediates for the preparation of dppiv inhibitors
    发明人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA
    权利人:ROY BHAIRAB NATH; KAMBOJ RAJENDER KUMAR; GOERGE SHAJI K; VENUGOPAL SPINVIN C; SHANMUGVADIVELU MUTHU KUMARAN; SINHA NEELIMA; LUPIN LTD
    摘要:An improved process for the synthesis of intermediates like Alkyl/Aralkyl (2S)-2-(tert-butoxycarbonyl)-amino-2-[-8-azabicyclo[3.2.1]oct-3-yl]-exo-acetate and analogs thereof which are useful in the synthesis of Dipeptidyl peptidase-IV (DP-PIV) inhibitors.

    专利号:US-8742028-B2
    优先权日:2009-05-06
    标 题:Solid support for Fmoc-solid phase synthesis of peptide acids
    发明人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R
    权利人:SRIVASTAVA KRIPA S; DAVIS MATTHEW R; MALLINCKRODT LLC
    摘要:The present invention provides a solid support for Fmoc-solid phase synthesis of peptides. In particular, the solid supports of the invention may be utilized to produce peptide acids.

    专利号:US-4284582-A
    优先权日:1978-04-28
    标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides
    发明人:KAYE ALBERT E; TUCKER ALAN C
    权利人:ICI LTD
    摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.

    专利号:US-8173817-B2
    优先权日:2004-05-28
    标 题 :Stereoselective synthesis of benzimidazole sulfoxides
    发明人:REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA
    权利人:REDDY BANDI PARTHASARADHI; REDDY KURA RATHNAKAR; REDDY RAPOLU RAJI; REDDY DASARI MURALIDHARA; HETERO DRUGS LTD
    摘要:The present invention relates to a process for stereoselective synthesis of substituted sulfoxides either as a single enantiomer or in an enantiomerically enriched form. Thus, 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]thio]-1H-benzimidazole is reacted with (R)-camphorsulfonyl chloride to form a mixture of 1-(R)-camphorsulfonyl-5- (and 6-)methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methylthio]-1H-benzimidazole, oxidized to obtain a diastereomeric excess of 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole over 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(R)-sulfinyl]-1H-benzimidazole, the diastereomers are separated by fractional crystallization and the separated 1-(R)-camphorsulfonyl-(5- and 6-)-methoxy-2-[(3,5-dimethyl-4-methoxy-2-pyridyl)methyl-(S)-sulfinyl]-1H-benzimidazole is deprotected to give esomeprazole.

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    合成参考文献


    摘要:Archivio Italiano di Scienze Farmacologiche., 15(1), 1937
    摘要:International Program on Chemical Safety/European Commission; International Chemical Safety Card (ICSC) on 1,2-Dichloroethylene (540-59-0) ICSC No. 0436 (July 2003). Available from, as of May 1, 2018:
    摘要:Goodebjauf O, Atkinsin JC; Ground Water 24: 231-233 (1986)
    摘要:Snedecor G et al; Chloroethylenes. Kirk-Othmer Encyclopedia of Chemical Technology (1999-2018). John Wiley & Sons, Inc. Online Posting Date: January 16, 2004
    摘要:Otson R et al; J Assoc Off Analyt Chem 65: 1370-4 (1982)
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