CAS: 517-10-2; Allocholesterol

上下游产品

胆固醇 Cholesterol 57-88-5
Cholest-4-En-3β-Yl-Trimethylsilylether 53084-65-4
4-胆甾烯-3-酮 Cholest-4-En-3-One 601-57-0
1,4-胆固醇二烯-3-酮 Cholesta-2,4-Diene 4117-50-4
胆甾-3,5-二烯 3,5-Cholestadiene 747-90-0
Cholesta-4,6-Diene 27425-93-0

📜胆固醇置于sodium Tetrahydroborate,Cerium(Iii) Chloride Heptahydrate,Aluminum Isopropoxide体系中,用 甲醇,环己酮,甲苯 作为反应溶剂,化学反应 10.0H,反应生成 别胆固醇
参考文献:Structure-activity Relationships Of Oxysterol-Derived Pharmacological Chaperones For Niemann-pick Type C1 Protein
标题:Structure-activity Relationships Of Oxysterol-Derived Pharmacological Chaperones For Niemann-pick Type C1 Protein
摘要:Niemann-Pick Disease Type C Is A Fatal Neurodegenerative Disease,And Its Major Cause Is Mutations In Npc1 Gene. This Gene Encodes Npc1 Protein,A Late Endosomal Polytopic Membrane Protein Required For Intracellular Cholesterol Trafficking. One Prevalent Mutation (11061T) Has Been Shown To Cause A Folding Defect,Which Results In Failure Of Endosomal Localization Of The Protein,Leading To Loss-Of-Function Phenotype. We Have Previously Demonstrated That Several Oxysterols And Their Derivatives Act As Pharmacological Chaperones; Binding Of These Compounds To Npc1(11061T) Mutant Protein Corrects The Localization/maturation Defect Of The Mutant Protein. Here,We Disclose Detailed Structure-Activity Relationships Of Oxysterol Derivatives As Pharmacological Chaperones For Npc1(11061T) Mutant. (C) 2014 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2014.05.064