CAS: 500-55-0; (8-Methyl-8-Azabicyclo[3.2.1]Octan-3-yl) 2-Phenylprop-2-Enoate

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CAS号51-55-8 阿托品； 颠茄碱 | CAS号101-31-5 天仙子胺 | CAS号7697-37-2 硝酸 | CAS号108-24-7 乙酸酐 | CAS号93-97-0 苯甲酸酐 | CAS号5908-99-6 一水硫酸阿托品 | CAS号7664-93-9 硫酸 | CAS号5226-98-2 (8-methyl-8-aza... | CAS号55-48-1 硫酸阿托品 | CAS号7732-18-5 水 | CAS号492-38-6 2-苯基丙烯酸 | CAS号7432-10-2 3-托品醇 | CAS号2292-12-8 8-Azabicyclo(3.... | CAS号2292-11-7 8-Azabicyclo(3....

专利信息

专利号:US-5900227-A
优先权日:1996-06-17
标题 :Multicyclic nitrone spin trapping compositions
发明人：JANZEN EDWARD G; SANKURATRI NAGARAJU
权利人:OKLAHOMA MED RES FOUND
摘要:Multicyclic nitrone spin trapping compounds capable of forming stable free radical spin adducts are provided as well as methods for their synthesis. The multicyclic nitrone spin trapping compounds can be reacted with a free radical, such as a hydroxy or hydroperoxy radical, in solution to form a spin adduct which is stable and readily detectable by electron paramagnetic resonance (EPR) spectroscopy. The multicyclic nitrone spin traps can be used to detect free radicals in a sample such as a biological system. In one embodiment, the spin trapping compound, 1,3,3-trimethyl-6-azabicyclo-[3.2.1]oct-6-ene-N-oxide ('TRAZON') is provided, as well as methods for the synthesis of TRAZON and of modified forms of TRAZON. TRAZON can react with a wide range of different free radicals in solution to form free radical spin adducts which are readily detectable by EPR.

专利号:US-8927485-B2
优先权日:2010-02-18
标题:Site-specific modification of proteins through chemical modification enabling protein conjugates, protein dimer formation, and stapled peptides
发明人：KRANTZ ALEXANDER; YU PENG
权利人:KRANTZ ALEXANDER; YU PENG; ADVANCED PROTEOME THERAPEUTICS INC
摘要:The present invention generally provides methods for the site-specific modification of peptides, polypeptides, and proteins, e.g., granulocyte macrophage colony-stimulating factor, human superoxide dismutase, annexin, leptin, antibodies and the like, cytokines and chemokines, at their N-termini and at sites at which unnatural aminoacids have been introduced along the protein framework. The modifications described herein can be used for the synthesis and application of the adducts in radio-labeling, molecular imaging and protein therapeutic applications, and the treatment of disorders such as rheumatoid arthritis, lupus erythematosus, psoriasis, multiple sclerosis, type-1 diabetes, Crohn's disease, and systemic sclerosis, Alzheimer disease, cancer, liver disease (e.g., alcoholic liver disease), and cachexia.

专利号:US-7993390-B2
优先权日:2002-02-08
标 题:Implantable or insertable medical device resistant to microbial growth and biofilm formation
发明人：MILLER KATHLEEN M; BUCAY-COUTO WEENNA; LI JIANMIN
权利人:BOSTON SCIENT SCIMED INC
摘要:Disclosed are implantable or insertable medical devices that provide resistance to microbial growth on and in the environment of the device and resistance to microbial adhesion and biofilm formation on the device. In particular, the invention discloses implantable or insertable medical devices that comprise at least one biocompatible matrix polymer region, an antimicrobial agent for providing resistance to microbial growth and/or a microbial adhesion/biofilm synthesis inhibitor for inhibiting the attachment of microbes and the synthesis and accumulation of biofilm on the surface of the medical device. Also disclosed are methods of manufacturing such devices under conditions that substantially prevent preferential partitioning of any of said bioactive agents to a surface of the biocompatible matrix polymer and substantially prevent chemical modification of said bioactive agents.