CAS: 476014-76-3; 4-Hydroxy-2-Piperidinone

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上下游产品

CAS号50607-30-2 2,4-哌啶二酮 | CAS号158849-52-6 4-cyano-3-hydro... | CAS号147028-51-1 4-cyano-3-hydro... | CAS号50607-30-2 2,4-哌啶二酮

2,4-哌啶二酮置于甲醇,Sodium Tetrahydroborate体系中,用87%的收率获得产物4-羟基-2-哌啶酮
参考文献: Substituted Cyclic Compounds And Methods Of Use[fr] Composés Cycliques Substitués Et Procédés D'Utilisation
标题: Substituted Cyclic Compounds And Methods Of Use[fr] Composés Cycliques Substitués Et Procédés D'Utilisation
摘要:本发明提供了新颖的取代环化合物,药用可接受的盐及其制剂,用于调节蛋白酪氨酸激酶活性,并调节细胞活动,如增殖,分化,凋亡,迁移和侵袭.该发明还提供了包括这些化合物的药用可接受的组合物,以及在治疗哺乳动物,特别是人类的增生性疾病中使用这些组合物的方法.

专利信息

专利号:US-8772301-B2
优先权日:2009-12-18
标题 :Compounds for treating disorders mediated by metabotropic glutamate receptor 5, and methods of use thereof
发明人：HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D
权利人:HARDY LARRY WENDELL; HEFFERNAN MICHELE L R; WU FRANK XINHE; SPEAR KERRY L; SARASWAT LAKSHMI D; SUNOVION PHARMACEUTICALS INC
摘要:Provided herein are compounds and methods of synthesis thereof. The compounds set forth herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, neurodegenerative disorders, neuropsychiatric disorders, disorders of cognition, learning or memory, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds set forth herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.