CAS: 4359-87-9; 2,4,6-Trichloro-5-Nitropyrimidine

相似化合物

91322-00-8 49845-33-2 4316-93-2

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CAS号106351-49-9 5-硝基嘧啶-2,4,6-三酚 | CAS号480-68-2 5-硝基巴比妥酸 | CAS号91-66-7 N,N-二乙基苯胺 | CAS号31221-68-8 2,6-二氯-5-硝基嘧啶-4-胺 | CAS号83356-02-9 2,4,6-三甲氧基-5-硝基嘧啶 | CAS号91322-00-8 2,4,6-三氯嘧啶-5-胺

5-硝基巴比妥酸置于n,N-二乙基苯胺,三氯氧磷体系中,化学反应生成 2,4,6-三氯-5-硝基嘧啶
参考文献:功能化嘧啶衍生物的简便制造:构建一个新的高性能和不太敏感的含能化合物家族
标题:功能化嘧啶衍生物的简便制造:构建一个新的高性能和不太敏感的含能化合物家族
摘要:一系列新型嘧啶基富氮绿色含能材料由市售廉价起始材料有效合成,反应时间短,易于分离,产率基本定量.使用红外,多核核磁共振 (NMR) 和质谱对所有分子进行了充分表征.化合物2,4和5通过15 N NMR光谱表征,化合物4通过单晶x射线衍射研究证实.对嘧啶衍生物的物理化学性质进行了详细的理论和实验研究.化合物2,3,9,10和12具有与二级基准炸药 Rdx 和 Hmx 相媲美的优异爆轰性能,非常好的热稳定性和低灵敏度.值得注意的是,化合物3,9和10的反应生成热,爆速和压力,分解温度和冲击敏感性的值被确定为 >250 Kj Mol-1,>9380 Ms-1,>32 Gpa,>170 oc 和 >30 J,分别.此外,化合物2,9和10的活化能和非等温热动力学参数采用基辛格法测定.发现将肼,硝基和n-氧化物基团结合到嘧啶骨架中会导致强烈的非键合相互作用,这有助于提高热稳定性并降低灵敏度.
DOI:10.1039/d2Ta02042D

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:WO-2015162630-A4
优先权日:2014-04-25
标 题 :Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.
发明人：RASADIA PUNITKUMAR RAMESHBHAI; RAMANI VAIBHAV NARENDRAKUMAR; PANDEY BIPIN; BHADANI VIJAY NAGJIBHAI; VACHHANI DIPAKKUMAR DHANJIBHAI; SHAH ANAMIK KANTILAL
权利人:ANLON CHEMICAL RES ORGANIZATION
摘要:The present invention relates to novel processes for preparing triazolo [4,5-d] pyrimidines, including Ticagrelor, via new intermediates and new routes of synthesis. The synthesis begins with readily available and inexpensive starting material such as 5-nitro-2,4,6-trichloropyrimidine and leads to series of novel intermediates, which are commercially viable and industrially advantageous (solid intermediates, high yields and convenient experimental condition) for the preparation of highly pure Ticagrelor.

专利号:WO-2015162630-A1
优先权日:2014-04-25
标题:Novel processes for preparing triazolo [4,5-d]- pyrimidines, including ticagrelor, vianew intermediates and new route of synthesis.