CAS: 41638-55-5; Butyl-1,1'-Biphenyl

专利信息

专利号:US-5214118-A
优先权日:1990-10-05
标 题:Process for synthesis of polyestercarbonate-siloxane copolymers
发明人：HAWKINS CHRISTOPHER M; ROSENQUIST NILES R
权利人:GEN ELECTRIC
摘要:A process for synthesizing polyestercarbonate-siloxane copolymers which have a smaller concentration of low molecular weight species and greater thermal stability has been described. Essentially the process includes adding the comonomer, diacid chloride siloxane, after approximately 1/3 of the phosgene has been added, in a conventional interfacial copolymerization, (as opposed to addition at the beginning of the polymerization).

专利号:US-4900818-A
优先权日:1987-12-14
标 题:Large scale synthesis of twelve member diazamonocyclic compounds
发明人：CZECH BRONISLAW P
权利人:TECHNICON INSTR
摘要:A process is disclosed for synthesizing large quantities of a compound of formula I ##STR1## wherein a solution of a compound of formula II ##STR2## is mixed with a solution of a compound of formula III ##STR3## under suitable process conditions, and wherein A, same or different, is N--R, O, S, CRR' or P(O)R, and R and R' are hydrogen, alkyl, alkylidene, aryl, tosyl, allyl or benzyl, and B is O. n Compounds of formula I may be reduced to form an azacorand of formula IV ##STR4## wherein K and L, same or different, are N--R, O, S, CRR', or P(O)R, and R and R' are hydrogen, alkyl, alkylidene, aryl, tosyl, allyl or benzyl. n Also disclosed in a compound of formula IV synthesized in accordance with the above procedure wherein K and L are not both O or S.

专利号:US-4782061-A
优先权日:1984-12-21
标题:Method of treating psychotropic conditions employing substituted piperazine compounds
发明人：KRUSE CORNELIS G; VAN DER HEYDEN JOHANNES A M; VAN WIJNGAARDEN INEKE; HARTOG JAN; OLIVIER BEREND
权利人:DUPHAR INT RES
摘要:The invention relates to a group of new bicyclic heteroarylpiperazine derivatives of formula 1. It was found that these compounds have interesting psychotropic in particular anti-psychotic properties. The compounds can be prepared according to methods known for the synthesis of analogous compounds.

专利号:US-6284928-B1
优先权日:1999-02-23
标题 :Process for preparing intermediates useful in the synthesis of vitamin D compounds
发明人：DANIEWSKI ANDRZEJ ROBERT
权利人:HOFFMANN LA ROCHE
摘要:The invention relates to an improved process for preparing [(3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione]. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R—Cu, wherein R is n and R 1 , R 2 and R 3 are each, independently, selected from the group consisting of C 1-7 alkyl, phenyl, phenyl substituted by at least one C 1-4 alkyl group, benzyl, or benzyl substituted by at at least one C 1-4 alkyl group to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.

专利号:WO-0212216-A1
优先权日:2000-08-08
标 题 :An improved process for the preparation of docetaxel
发明人：DUVVURI SUBRAHMANYAM; PURANIK RAMACHANDRA
权利人:REDDY RESEARCH FOUNDATION; DUVVURI SUBRAHMANYAM; PURANIK RAMACHANDRA
摘要:The present invention relates to an improved process for the preparation of antitumor drug 'Docetaxel'. The present invention more particulary relates to a short synthesis of docetaxel following a semi-synthetic approach comprising C-13 esterification of a suitably protected 10-deacetylbaccatin III with a suitably protected side chain acid and subsequent deprotections to produce docetaxel. The process described in the present invention comprises (i) reacting 10-deacetylbaccatin III with a heterocyclic compound to produce a novel 7,10-diprotected 10-deacetylbaccatin III (ii) esterifying the C-13 hydroxyl group in the 7,10-diprotected 10-deacetylbaccatin III compound obtained in step (i) with an oxazolidine side chain acid to obtain a novel C-13 coupled adduct (iii) deprotecting the protecting groups at C-7, C-10 & oxazolidine group an intermediate amino alcohol (iv) derivatising the free amine group in the amino alcohol obtained in the step (iii) with di-tert. butyl dicarbonate to get the desired 'Docetaxel' compound.

专利号:US-4021429-A
优先权日:1975-07-24
标 题 :Synthesis of ethylenically unsaturated compounds from esters or amides
发明人：SCHROCK RICHARD ROYCE
权利人:DU PONT
摘要:Certain hydrocarbylidene-niobium or -tantalum complexes react with esters or N,N-disubstituted amides to produce ethylenically unsaturated compounds. Exemplary is the reaction of trineopentyl(neopentylidene)tantalum with ethyl acetate to produce 2-ethoxy-4,4-dimethyl-2-pentene: