CAS: 3621-36-1; 2-Hydroxy-3,9,10-Trimethoxy-5,6-Dihydroisoquinolino[3,2-A]Isoquinolin-7-Ium

该化合物是属于Menispermaceae家族的植物来源,是一种藻类,其特点是结构复杂,包括一个四环框架;Columbamine展示了一系列生物活动,包括抗微生物和抗炎特性,使其对药理研究感兴趣;该化合物通常以黄晶状固体的形式出现,在有机溶剂中溶解;其分子公式反映了碳,氢,氮和氧原子的具体安排,有助于其独特的化学行为;在安全方面,像许多alkolimoles一样,应小心处理共聚物,因为它可能在某些浓度上产生有毒影响;研究继续探索其潜在的治疗用途,特别是在传统医学方面,它被用于其所谓的健康利益;

结构式图片

上下游产品

CAS号483-34-1 (-)-异延胡索单酚碱 | CAS号605-34-5 discretamine | CAS号485-19-8 牛心果鹼

合成工艺路线路线简述

    📜四氢非洲防己胺 反应生成非洲防己碱
    参考文献:Berberine Synthase,The Methylenedioxy Group Forming Enzyme Inberberine Synthesis
    标题:Berberine Synthase,The Methylenedioxy Group Forming Enzyme Inberberine Synthesis
    摘要:
    Doi:10.1016/s0040-4039(00)61879-8

    海关参考信息

    专利信息


    专利号:US-2017058305-A1
    优先权日:2014-04-29
    标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

    专利号:US-2021198706-A1
    优先权日:2014-04-29
    标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds

    专利号:US-2011296543-A1
    优先权日:2006-06-01
    标题:Nucleic acids and proteins and methods for making and using them
    发明人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON
    权利人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON; UNIV CALIFORNIA; CALIFORNIA INST OF TECHN; VERENIUM CORP
    摘要:The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.

    专利号:CN-112851661-A
    优先权日:2021-01-08
    标 题:A method for the modular and diverse synthesis of triphenanthridine and protoberberine alkaloids

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献


    1: Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma [Retraction]. Cancer Manag Res. 2021 Jul 19;13:5761. doi: 10.2147/CMAR.S329186.
    2: Niu HT, Liu Y, Wang YZ, Tian Y, Yang M, Jiang HS. Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma. Cancer Manag Res. 2021 Jan 19;13:489-497. doi: 10.2147/CMAR.S286866. Retraction in: Cancer Manag Res. 2021 Jul 19;13:5761.
    3: Wang K, Feng X, Chai L, Cao S, Qiu F. The metabolism of berberine and its contribution to the pharmacological effects. Drug Metab Rev. 2017 May;49(2):139-157. doi: 10.1080/03602532.2017.1306544. Epub 2017 Apr 3. 41(1):99-104. doi: 10.1080/10799893.2020.1794003. Epub 2020 Jul 16.

    合成参考文献


    参考文献:10.1002/rcm.2593
    摘要:Zhang Y, Shi Q, Shi P, Zhang W, Cheng Y. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin‐Guo‐Lan ( Tinospora sagittata and Tinospora capillipes ) by high‐performance liquid chromatography/electrospray ionization with multistage mass spectrometry. Rapid Comm Mass Spectrometry. 2006 Jul 03;20(15):2328–42. doi: 10.1002/rcm.2593.
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