专利号:US-2017058305-A1 优先权日:2014-04-29 标 题:Improved Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:US-2021198706-A1 优先权日:2014-04-29 标题 :Methods For Making and Using Polynucleotide Sequences in the Synthesis of Alkaloid Compounds
专利号:US-2011296543-A1 优先权日:2006-06-01 标题:Nucleic acids and proteins and methods for making and using them 发明人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON 权利人:CHANG HWAI; MATHUR ERIC J; CAYOUETTE MICHELLE; ROBERTSON DAN E; HUGENHOLTZ PHILIP; WARNECKE FALK; LEADBETTER JARED R; IVANOVA NATALIA; LUGINBUHL PETER; HUTCHISON DON; UNIV CALIFORNIA; CALIFORNIA INST OF TECHN; VERENIUM CORP 摘要:The invention provides polypeptides, including enzymes, structural proteins and binding proteins, polynucleotides encoding these polypeptides, and methods of making and using these polynucleotides and polypeptides. Polypeptides, including enzymes and antibodies, and nucleic acids of the invention can be used in industrial, experimental, food and feed processing, nutritional and pharmaceutical applications, e.g., for food and feed supplements, colorants, neutraceuticals, cosmetic and pharmaceutical needs. Polypeptides of the invention can be used in food processing, brewing, bath additives, alcohol production, peptide synthesis, enantioselectivity, hide preparation in the leather industry, waste management and animal degradation, silver recovery in the photographic industry, medical treatment, silk degumming, biofilm degradation, biomass conversion to a biofuel (e.g., a bioethanol, biomethanol, biopropanol or biobutanol, a biodiesel, etc.), biodefense, antimicrobial agents and disinfectants, personal care and cosmetics, biotech reagents, in corn wet milling and pharmaceuticals such as digestive aids and anti-inflammatory (anti-phlogistic) agents.
专利号:CN-112851661-A 优先权日:2021-01-08 标 题:A method for the modular and diverse synthesis of triphenanthridine and protoberberine alkaloids
1: Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma [Retraction]. Cancer Manag Res. 2021 Jul 19;13:5761. doi: 10.2147/CMAR.S329186. 2: Niu HT, Liu Y, Wang YZ, Tian Y, Yang M, Jiang HS. Columbamine-Mediated PTEN/AKT Signal Pathway Regulates the Progression of Glioma. Cancer Manag Res. 2021 Jan 19;13:489-497. doi: 10.2147/CMAR.S286866. Retraction in: Cancer Manag Res. 2021 Jul 19;13:5761. 3: Wang K, Feng X, Chai L, Cao S, Qiu F. The metabolism of berberine and its contribution to the pharmacological effects. Drug Metab Rev. 2017 May;49(2):139-157. doi: 10.1080/03602532.2017.1306544. Epub 2017 Apr 3. 41(1):99-104. doi: 10.1080/10799893.2020.1794003. Epub 2020 Jul 16.
合成参考文献
参考文献:10.1002/rcm.2593 摘要:Zhang Y, Shi Q, Shi P, Zhang W, Cheng Y. Characterization of isoquinoline alkaloids, diterpenoids and steroids in the Chinese herb Jin‐Guo‐Lan ( Tinospora sagittata and Tinospora capillipes ) by high‐performance liquid chromatography/electrospray ionization with multistage mass spectrometry. Rapid Comm Mass Spectrometry. 2006 Jul 03;20(15):2328–42. doi: 10.1002/rcm.2593.