CAS: 34284-87-2; 6-(Methylamino)Pyrimidine-2,4-Diol

相似化合物

873-83-6 1122-67-4 186435-66-5

上下游产品

CAS号4270-27-3 6-氯尿嘧啶 | CAS号74-89-5 氨基甲烷 | CAS号55441-71-9 9-甲基尿酸 | CAS号856974-71-5 (2,6-bis-benzyl... | CAS号32998-03-1 2,6-二氯-N-甲基嘧啶-4-胺 | CAS号27132-53-2 10-甲基嘧啶并[4,5-b]... | CAS号26908-38-3 脱氮黄素

📜9-甲基尿酸置于乙二胺四乙酸,氧化亚氮体系中,用 Phosphate Buffer 作为反应溶剂,化学反应生成 6-甲氨基尿嘧啶
参考文献:Inactivation Of Nitric Oxide By Uric Acid
标题:Inactivation Of Nitric Oxide By Uric Acid
摘要:The 1980 Identification Of Nitric Oxide (No) As An Endothelial Cell-Derived Relaxing Factor Resulted In An Unprecedented Biomedical Research Of No And Established No As One Of The Most Important Cardiovascular,Nervous And Immune System Regulatory Molecule. A Reduction In Endothelial Cell No Levels Leading To Endothelial Dysfunction Has Been Identified As A Key Pathogenic Event Preceding The Development Of Hypertension,Metabolic Syndrome,And Cardiovascular Disease. The Reduction In Endothelial No In Cardiovascular Disease Has Been Attributed To The Action Of Oxidants That Either Directly React With No Or Uncouple Its Substrate Enzyme. In This Report,We Demonstrate That Uric Acid (Ua),The Most Abundant Antioxidant In Plasma,Reacts Directly With No In A Rapid Irreversible Reaction Resulting In The Formation Of 6-Aminouracil And Depletion Of No. We Further Show That This Reaction occurs Preferentially With No Even In The Presence Of Oxidants Peroxynitrite And Hydrogen Peroxide And That The Reaction Is At Least Partially Blocked By Glutathione. This Study Shows A Potential Mechanism By Which Ua May Deplete No And Cause Endothelial Dysfunction,Particularly Under Conditions Of Oxidative Stress In Which Ua Is Elevated And Intracellular Glutathione Is Depleted.
DOI:10.1080/15257770802257952