CAS: 3034-22-8; 5-Bromothiazol-2-Amine

该化合物是一种有机化合物,其特点是硫化环,即五人组成的含有硫和氮原子的环环环结构.在2点和5点存在一个氨基组(-NH2),5点存在一个溴原子,有助于其反应和在各种化学反应中的潜在应用.该化合物一般是固体,在极地溶剂中溶解.它以生物活动著称,它具有医学化学意义,特别是在药品开发方面.硫酸盐的细胞常与多种生物特性有关,包括抗微生物和抗硫酸盐活动.此外,2-氨基-5-溴-甲诺尔可以参与各种合成变异,作为复杂分子的建筑块.安全数据表明,与许多溴化化合物一样,它应该受到潜在毒性和环境关切的注意.

英文名称5-Bromothiazol-2-Amine
中文名称5-溴噻唑-2-胺
IUPAC名称5-bromo-1,3-thiazol-2-amine
其它别名5-bromo-thiazol-2-ylamine; 2-amino-5-bromothiazole; 5-bromo-1,3-thiazol-2-ylamine; 5-bromo-2-aminothiazole hydrobromide; 2-thiazolamine, 5-bromo-; 2-amino-5-bromo-1,3-thiazole; 5-bromo-2-aminothiazole hydrobromide, hplc
CAS编号3034-22-8
MFCD编号:MFCD00016893
EINECS号:819-500-2
分子式:C3H3BrN2S
分子量:179.04
产品CID: 1288060
产品分类有机原料→分子砌块→芳杂环类化合物→噻唑类化合物

相似结构搜索
产品信息参考;;;;
InChIKey: ARHCLXWELPFVFQ-UHFFFAOYSA-N
1S/C3H3BrN2S/c4-2-1-6-3(5)7-2/h1H,(H2,5,6)…
计算化学: 氢键受体数3.0氢键供体数1.0可旋转键数0.0

物理性质

熔点165°C
沸点287.6°C at 760 mmHg
闪点127.7±19.8 °C
密度2.0±0.1 g/cm3
pKa:3.22±0.10(预测)
PSA:38.91
LogP:1.4878
折射率1.691
蒸汽压0.0±0.6 mmHg at 25°C
敏感性遵照规定使用和储存则不会分解。
外观形态白色固体
储存条件请置于阴暗处, 惰性气氛中,冷冻保存, 低于 -20°C
产品应用该化合物用于其他生物的试验机体,以测量其对不同类型化学品的敏感度.还表明它对碳氢分子有影响,这已证明对细菌等生物有影响.

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302-H315-H319-H335
防范说明P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
危险品标志Xn
安全声明26-36/37
危险类别码22-36
WGK Germany3

上下游产品

合成工艺路线路线简述

合成目标产物 2-Amino-5-Bromothiazole 主要起始原料 2-Aminothiazole
(文献来源)合成步骤主要原料 2-Aminothiazole

2-氨基噻唑置于n-溴代丁二酰亚胺(Nbs)体系中,用溶剂黄146 用作溶剂,化学反应生成2-氨基-5-溴噻唑
参考文献:顺序溴化-脱溴方法合成溴化噻唑
标题:顺序溴化-脱溴方法合成溴化噻唑
摘要:溴噻唑全家族的合成已被重新研究,以更新和优化其生产.报告的物种包括2-溴噻唑,4-溴噻唑,5-溴噻唑,2,4-二溴噻唑,2,5-二溴噻唑,4,5-二溴噻唑和2,4,5-三溴噻唑,其中大多数是通过依次进行溴化和脱溴步骤.现在可以在不使用元素溴的情况下生产该完整家族,并且所提出的方法已允许首次报道该完整家族的物理和NMR光谱表征.
Doi:10.1021/acs.Joc.7B00495

专利信息

专利号:US-2025129021-A1
优先权日:2023-09-19
标题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:US-6531470-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-6562844-B2
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:US-7002020-B1
优先权日:1998-01-23
标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.

专利号:CN-115785022-B
优先权日:2022-12-05
标题:Synthesis of 2-amino-5-bromo-1,3,4-thiazole, an intermediate of cationic blue 159

专利号:CN-115785022-A
优先权日:2022-12-05
标题 :Synthesis of Cationic Blue 159 Intermediate 2-amino-5-bromo-1,3,4-thiazole