CAS: 2378-95-2; (S)-Diethyl 2-(4-(Methylamino)Benzamido)Pentanedioate

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CAS号115827-03-7 diethyl N-[p-(N... | CAS号13726-52-8 N-(4-氨基苯(甲)酰)-L... | CAS号74-88-4 碘甲烷 | CAS号70280-70-5 diethyl N-[p-(b... | CAS号38974-68-4 N-对碘苯甲酰-L-谷氨酸 | CAS号74-89-5 氨基甲烷 | CAS号584-08-7 碳酸钾 | CAS号4271-30-1 N-(4-氨基甲酰)-L-谷氨酸 | CAS号59-05-2 甲氨蝶呤 | CAS号76822-62-3 L-Glutamic acid...

Diethyl N--L-Glutamate置于palladium On Activated Charcoal 盐酸,氢气体系中,用 乙醇 用作溶剂,化学反应 3.0H,以80%的收率获得对甲胺基苯甲酰谷氨酸二乙酯
参考文献:A Pyrimidine-Based "Flexible" Bisubstrate Analog Inhibitor Of Human Thymidylate Synthase
标题:A Pyrimidine-Based "Flexible" Bisubstrate Analog Inhibitor Of Human Thymidylate Synthase
摘要:The Synthesis And Characterization Of Two "Flexible" Bisubstrate Analogues Of The Intermediate In The Thymidylate Synthase Reaction Are Reported. Steric Constraints Are Minimized And Diasteromeric Mixtures Avoided By Using A Pyrimidine-Based Analogue As The Folate Portion Of The Inhibitor While Retaining All Known Important Binding Sites. A Preliminary Assessment Of Certain Conformational Parameters By NMR Is Presented. The Compounds Are Shown To Be Potent Competitive Inhibitors With Respect To Dump Or 5,10-Ch2-H4Pteglu But Gave Mixed Kinetics With Respect To 5,10-Ch2-H4Pteglu5 For Human Thymidylate Synthase.
Doi:10.1021/jm00119A012

专利信息

专利号:US-4136101-A
优先权日:1978-02-03
标题:Process for preparing dialkyl (p-aminobenzoyl) glutamates
发明人：KAZAN JOHN
权利人:AMERICAN CYANAMID CO
摘要:A process for the preparation of dialkyl (p-aminobenzoyl) glutamates is disclosed. Dialkyl (p-Aminobenzoyl) glutamates are useful as intermediates in the synthesis of N-{p-([(2,4-diamino-6-pteridinyl)-methyl]methylamino)benzoyl} glutamic acid, also known as 4-amino-N 10 -methylpteroylglutamic acid. The compound zinc N-(p-methylaminobenzoyl)-L-(+)-glutamate, is also disclosed.