参考标题:Highly Efficient Synthesis Of Aryl And Heteroaryl Trifluoromethyl Ketones Via O-Iodobenzoic Acid (Ibx) 作者:Huicheng Cheng,Yu Pei,Faqiang Leng,Jingya Li,Apeng Liang,Dapeng Zou,Yangjie Wu,Yusheng Wu |发布日期:2013.8 摘要:A Two-Step Process For The Synthesis Of Aryl And Heteroaryl Trifluoromethyl Ketones From The Corresponding Aldehydes Is Described. Trifluoromethyl Alcohols Were Prepared From Aryl And Heteroaryl Aldehydes In Excellent Yields Using Catalytic Amount Of K2Co3. The Trifluoromethyl Alcohols Were Then Oxidized Conveniently And Efficiently By O-Iodoxybenzoic Acid (Ibx) Under Mild Conditions To Get The Desired
合成参考文献
参考文献:10.1016/j.bmc.2014.10.001 摘要:Tani N, Juvonen RO, Raunio H, Fashe M, Leppänen J, Zhao B, Tyndale RF, Rahnasto-Rilla M. Rational design of novel CYP2A6 inhibitors. Bioorg Med Chem. 2014 Dec 01;22(23):6655–64. doi: 10.1016/j.bmc.2014.10.001.