CAS: 19794-53-7; 2-Amino-3-Methoxypropanoic Acid

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32620-11-4 86118-11-8 302-84-1

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CAS号65090-78-0 2-溴-3-甲氧基丙酸 | CAS号98632-99-6 2-乙酰氨基-3-甲氧基丙酸 | CAS号2544-05-0 2-氯-3-甲氧基丙酸 | CAS号302-84-1 DL-丝氨酸 | CAS号3183-36-6 Alanine,N-(dich...

📜N-乙酰基-O-甲基丝氨酸置于pig Kidney Acylase I体系中,用 Phosphate Buffer 用作溶剂,化学反应 0.17H,反应生成Dl-O-甲基丝氨酸
参考文献:Acylase I-Catalyzed Deacetylation Of N-Acetyl-L-Cysteine And S-Alkyl-N-Acetyl-L-Cysteines
标题:Acylase I-Catalyzed Deacetylation Of N-Acetyl-L-Cysteine And S-Alkyl-N-Acetyl-L-Cysteines
摘要:The Aminoacylase That Catalyzes The Hydrolysis Of N-Acetyl-L-Cysteine (Nac) Was Identified As Acylase I After Purification By Column Chromatography And Electrophoretic Analysis. Rat Kidney Cytosol Was Fractionated By Ammonium Sulfate Precipitation,And The Proteins Were Separated By Ion-Exchange Column Chromatography,Gel-Filtration Column Chromatography,And Hydrophobic Interaction Column Chromatography. Acylase Activity With Nac And N-Acetyl-L-Methionine (Nam),A Known Substrate For Acylase I,As Substrates Coeluted During All Chromatographic Steps. Sodium Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis Showed That The Protein Was Purified To Near Homogeneity And Had A Subunit M-R Of 43 000,Which Is Identical With The M-R Of Acylase I From Porcine Kidney And Bovine Liver. N-Butylmalonic Acid Was A Slow-Binding Inhibitor Of Acylase I And Inhibited The Deacetylation Of Nac With A K-I Of 192 +/-27 Mu M These Results Show That Acylase I Catalyzes The Deacetylation Of Nag. The Acylase I-Catalyzed Deacetylation Of A Range Of S-Alkyl-N-Acetyl-L-Cysteines,Their Carbon And Oxygen Analogues,And The Selenium Analogue Of Nam Was Also Studied With Porcine Kidney Acylase I. The Specific Activity Of The Acylase I-Catalyzed Deacetylation Of These Substrates Was Related To Their Calculated Molar Volumes And Lag P Values. The S-Alkyl-N-Acetyl-L-Cysteines With Short (C-0-C-3) And Unbranched S-Alkyl Substituents Were Good Acylase I Substrates,Whereas The S-Alkyl-N-Acetyl-L-Cysteines With Long (>C-3) And Branched S-Alkyl Substituents Were Poor Acylase I Substrates. The Carbon And Oxygen Analogues Of S-Methyl-N-Acetyl-L-Cysteine And The Carbon Analogue Of S-Ethyl-N-Acetyl-L-Cysteine Were Poor Acylase I Substrates,Whereas The Selenium Analogue Of Nam Was A Good Acylase I Substrate.
Doi:10.1021/tx980018B

专利信息

专利号:US-7459443-B2
优先权日:1999-04-08
标 题 :Synthesis of biologically active compounds in cells
发明人：SERGEEV PAVEL
权利人:SERGEEV PAVEL
摘要:This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of determined sequence. The method is based on the hybridization of two or more oligomers bound with biologically inactive precursors of biologically active substances to specific RNA or DNA in vivo in the cells of living organisms. After hybridization of the oligomers to RNA or DNA the biologically inactive precursors bound to the 5′ and/or 3′ ends of the oligomers can interact with each other to make biologically active form of the substances. This changing of properties is due to chemical reactions which bind the biologically inactive precursors through a chemical bond into a biologically active form of the whole compound.

专利号:US-8598089-B2
优先权日:2003-12-17
标题 :Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-8410028-B2
优先权日:2003-12-17
标 题:Methods for synthesis of encoded libraries
发明人：MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A
权利人:MORGAN BARRY; HALE STEPHEN; ARICO-MUENDEL CHRISTOPHER C; CLARK MATTHEW; WAGNER RICHARD; ISRAEL DAVID I; GEFTER MALCOLM L; BENJAMIN DENNIS; HANSEN NILS JAKOB VEST; KAVARANA MALCOLM J; CREASER STEFFAN PHILLIP; FRANKLIN GEORGE J; CENTRELLA PAOLO A; ACHARYA RAKSHA A; GLAXOSMITHKLINE LLC
摘要:The present invention provides a method of synthesizing libraries of molecules which include an encoding oligonucleotide tag.

专利号:US-7060818-B2
优先权日:2003-02-21
标题:Synthesis of macrocyclic tetraamido compounds and new metal insertion process
发明人：HORWITZ COLIN P; GHOSH ANINDYA
权利人:UNIV CARNEGIE MELLON
摘要:An improved method of synthesizing a macrocyclic tetraamido compound includes protecting the amino portion of an amino carboxylic acid to form a protected amino carboxylic acid; exposing the protected amino carboxylic acid to a first solvent, preferably a hydrocarbon solvent, such as toluene or 1,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane. The carboxylic acid portion of the protected amino carboxylic acid is then converted to an activated carboxylic acid by one of esterification or acid halide formation, to form a protected amino activated carboxylic acid derivative. The protected amino activated carboxylic acid derivative is reacted with a diamine in the presence of a second solvent, such as THF or ,2-dichloroethane, dichloromethane, dibromomethane and 1,2-dibromoethane, to form a protected diamide diamine intermediate. Following deprotection, the diamide diamine intermediate is reacted with an activated diacid, such as an activated malonate, oxalate or succinate derivative to form the macrocyclic tetraamido compound. The macrocyclic tetraamido compound may further be complexed with a transition metal.

专利号:US-8039236-B2
优先权日:2002-12-26
标 题:Process for producing dipeptides
发明人：HASHIMOTO SHIN-ICHI; TABATA KAZUHIKO; KUBOTA AYA; IKEDA HAJIME
权利人:KYOWA HAKKO BIO CO LTD
摘要:The present invention provides a protein which catalyzes the synthesis of a dipeptide different from L-Ala-L-Ala, a process for producing the protein which catalyzes the synthesis of a dipeptide, a process for producing a dipeptide using the protein which catalyzes the synthesis of a dipeptide, and a process for producing the dipeptide using a culture of a microorganism producing the protein which catalyzes the synthesis of a dipeptide or the like as an enzyme source.

专利号:US-2009017161-A1
优先权日:2006-02-28
标 题 :Gene encoding protein having trehalose synthesis-promoting activity and use thereof
发明人：NAKAO YOSHIHIRO; KODAMA YUKIKO; SHIMONAGA TOMOKO
权利人:SUNTORY LTD
摘要:The present invention relates to a gene encoding a protein having a trehalose synthesis-promoting activity and use thereof, in particular, a yeast for practical use with superior resistance property to dryness and/or low-temperature storage, alcoholic beverages produced with said yeast, and a method for producing said beverages. More particularly, the present invention relates to a yeast, whose resistance property to dryness and/or resistance property to low-temperature storage is enhanced by amplifying expression level of TSL1 gene encoding a protein Ts11p having a trehalose synthesis-promoting activity in brewer's yeast, especially non-ScTSL1 gene specific to a lager brewing yeast and to a method for producing alcoholic beverages with said yeast, etc.