CAS: 1978-37-6; 3-Fluoro-N-Methylaniline

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3-Fluoro-N-Methylformanilide置于c18H37Clmono2P2,氢气,三乙基硼氢化钠体系中,用 四氢呋喃,甲苯 用作溶剂,100.0 °C,5.0 Mpa 条件下,反应 24.0H,以98%的收率获得3-氟-N-甲基苯胺
参考文献:钼钳络合物催化的酰胺的高选择性加氢:范围和机理.
标题:钼钳络合物催化的酰胺的高选择性加氢:范围和机理.
摘要:一系列钼钳配合物首次被证明在酰胺的催化加氢中具有活性.在测试的催化剂中,Mo-1A被证明特别适合n-甲基化甲酰苯胺的选择性 C-N 氢解.值得注意的是,在某些可还原基团(甚至包括其他酰胺)的存在下观测到了高化学选择性.以阴离子 Mo(0) 作为活性物质,可以使一般催化性能和选择性问题合理化.酰胺co还原和伯酰胺催化剂中毒之间的相互作用解释了n的选择性加氢-甲基化甲酰苯胺.发现催化剂静止状态是通过与醇产物反应形成的mo-Alkoxo络合物.该物种扮演两个相反的角色--它促进了 C-N 键的质子分解,但阻碍了氢的活化.
Doi:10.1039/c9Sc03453F

专利信息

专利号:US-6207836-B1
优先权日:1993-02-17
标 题 :Indolin-2-one derivatives
发明人：ESAKI TORU; EMURA TAKASHI; HOSHINO EIICHI
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:A compound represented by formula (I):wherein R1 represents a halogen atom, a lower alkyl group, a lower alkoxy group, a hydroxyl group, a nitro group, a trifluoromethyl group, a lower alkylthio group, an acyl group, a carboxyl group, a mercapto group or an amino group; R2 represents a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group, an alkoxy group, an acyl group, an aryl group or a heterocyclic group; R3 represents a lower alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R4 represents a hydrogen atom, a lower alkyl group, an aryl group, a heterocyclic group, -OR5, -SR5 or -NR6R7 (wherein R5, R6, and R7 each represent a lower alkyl group, etc.); X and Y each represent -CH2-, -NH- or -O-; and n represents an integer of from 0 to 4, and an intermediate for synthesis thereof are disclosed. The compound of the present invention exhibits selective antagonism against gastrin receptors without causing side effects attributed to CCK-A receptor antagonism and is useful for the treatment and prevention of peptic ulcers, gastritis, reflux esophagitis, and Zollinger-Ellison syndrome, and for the treatment of neoplasm originating in the gastrointestinal system.