CAS: 1205-02-3; Benzoyl-Dl-Alanine

相似化合物

2198-64-3 17966-60-8 38767-73-6

上下游产品

rac-Ala-OH benzoyl chloride N-benzoyl-alanine trimethylsilanyl esterN-benzoyl-alanine trimethylsilanyl ester -propionsaeure-anilid2-α-Anilino-isobutyrylamino-propionsaeure-anilidmethyl N-benzoylalaninate N-(1-methoxyethyl)benzamide N-benzoyl-alanine trimethylsilanyl esterN-benzoyl-alanine trimethylsilanyl ester N-(1-benzoyl-3,5-dimethyl-2,4-dioxo-pyrrolidin-3-yl)-benzamideN-(1-benzoyl-3,5-dimethyl-2,4-dioxo-pyrrolidin-3-yl)-benzamide

📜Methyl N-Benzoylalaninate置于甲醇,Sodium Hydroxide体系中,化学反应生成N-苯甲酰基-Dl-丙氨酸
参考文献:Lawesson 试剂促进吖内酯脱氧合成 2,4-二取代噻唑
标题:Lawesson 试剂促进吖内酯脱氧合成 2,4-二取代噻唑
摘要:吖内酯和噻唑是常见的结构基序,具有多种应用.开发了一种从吖内酯高效直接合成 2,4-二取代噻唑的新方法.在没有金属或外部添加剂的情况下,通过lawesson 试剂对二氢唑酮进行脱氧来进行反应.合成了多种 2,4-二取代噻唑,收率高达 92%.此外,克级合成也证明了这种方法的重要性.
Doi:10.1039/d2Ob01939F

专利信息

专利号:US-10676423-B2
优先权日:2017-02-21
标题 :Structure and synthesis of highly fluorinated amino acid derivatives
发明人：WEAVER JIMMIE DEAN; TEEGARDIN KIP ALLEN; ARORA AMANDEEP
权利人:UNIV OKLAHOMA STATE
摘要:Methods of synthesizing polyfluorinated amino acid derivatives are disclosed, along with polyfluorinated amino acid derivatives produced from said methods, as well as compositions containing same. The synthesis methods utilize an oxazolone and a perfluoroarene to produce the polyfluorinated amino acid derivatives.

专利号:US-2010273787-A1
优先权日:2007-11-15
标题:Kynurenine-aminotransferase inhibitors
发明人：SCHWARCZ ROBERT; KAJII YASUSHI; ONO SHIN-ICHIRO
权利人:SCHWARCZ ROBERT; KAJII YASUSHI; ONO SHIN-ICHIRO
摘要:Compounds of formula (I): prodrug derivatives and/or pharmaceutically acceptable salt thereof, selectively inhibit the enzyme kynurenine aminotransferase, thereby reducing the synthesis of kynurenic acid. The compounds are used for the treatment of psychiatric and neurological diseases which benefit from an increase in glutamatergic and/or cholinergic neurotransmission, such as schizophrenia, depression, bipolar illness, anxiety and Alzheimer's disease. Furthermore, the compounds of the invention are useful for stimulating attention, memory and other cognitive processes in normal individuals of any age, including children, adolescents and the elderly. Additionally, the compounds of the invention are also useful for treatment of patients suffering from malaria by preventing parasite gametogenesis and fertility based on reduction of xanthurenic acid formation from its bioprecursor 3-hydroxy kynurenine.

专利号:WO-2006013085-A1
优先权日:2004-08-06
标题 :4-sulfonyl-substituted benzoylalanine derivates useful as kynurenine-aminotransferase inhibitors
发明人：PELLICCIARI ROBERTO; SCHWARCZ ROBERT; GUIDETTI PAOLO
权利人:PELLICCIARI ROBERTO; SCHWARCZ ROBERT; GUIDETTI PAOLO
摘要:The invention relates to compounds of formula (I), in which R, R' and R' are as defined in the disclosure and the pharmaceutically acceptable esters thereof. The compounds of the invention reduce the synthesis of kynurenic acid thus inhibiting the enzyme kynurenine aminotransferase and can be used for the preparation of medicaments for the treatment of those psychiatric and neurological diseases which benefit from an increase in glutamatergic and/or cholinergic neurotransmission, such as depression, bipolar illness, anxiety, Alzheimer's disease. Furthemore, the compounds of the invention are useful for stimulating attention, memory and other cognitive processes in normal individuals of any age, including children, adolescents and the elderly.

专利号:US-2020123099-A1
优先权日:2017-02-21
标题 :Structure and Synthesis of Highly Fluorinated Amino Acid Derivatives

专利号:US-5514694-A
优先权日:1992-09-21
标题 :Peptidyl ketoamides
发明人：POWERS JAMES C; LI ZHAOZHAO; PATIL GIRISH S; CHU DER-LUN
权利人:GEORGIA TECH RES INST
摘要:A novel class of peptide alpha -ketoamides useful for selectively inhibiting serine proteases, selectively inhibiting cysteine proteases, generally inhibiting all serine proteases, and generally inhibiting all cysteine proteases, having the formula Y-CO-AA2-AA1-CO-NH-X. Processes for the synthesis of peptidyl alpha -ketoamide derivatives.

专利号:US-8518885-B2
优先权日:2008-02-06
标题 :Heterocyclic peptide ketoamides
发明人：POWERS JAMES C; GLASS JONATHAN D; OVAT ASLI; LI ZHAOZHAO
权利人:POWERS JAMES C; GLASS JONATHAN D; OVAT ASLI; LI ZHAOZHAO; GEORGIA TECH RES INST; UNIV EMORY
摘要:A novel class of peptide α-ketoamides useful for selectively inhibiting calpains, selectively inhibiting cysteine proteases, and generally inhibiting all cysteine proteases, having the formula M-AA 2 -AA 1 -CO—NH—(CH 2 ) n —R 3 . Processes for the synthesis of peptidyl α-ketoamide derivatives. Compositions and methods for inhibiting cysteine proteases, inhibiting calpains, and treating disease caused by cysteine proteases and calpains are provided.