CAS: 1145-98-8; 1,1,2,2-Tetramethyl-1,2-Diphenyldisilane

相似化合物

1172-76-5 6009-50-3 941-15-1

上下游产品

phenyldimethylsilyl chloride triethylsilane 1,1,2,2,3,3-tetramethyl-1,3-diphenyltrisilane 5-decyne1,2-dichlorotetramethylsilane 1,2-dibromo-1,1,2,2-tetramethyldisilane Dimethyldiphenylsilane 1,1,3,3-tetramethyl-1,3-diphenyldisiloxane

📜二甲基苯基硅烷置于bis-Triphenylphosphine-Palladium(II) Chloride,2-(苄氧基)-4,6-二甲氧基-1,3,5-三嗪体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 6.0H,反应生成二苯基四甲基二硅烷
参考文献:在氢硅烷存在下通过钯催化的c-O / C-N键裂解获得醛的策略
标题:在氢硅烷存在下通过钯催化的c-O / C-N键裂解获得醛的策略
摘要:我们报告了选择性的c(酰基)-X(x = O,N)裂解,通过钯催化的方法获得醛官能团,从而催化活性酯和酰胺的催化还原.氢化硅烷作为还原剂可以促进反应,其收率好至极好,并且对c(酰基)-N和c(酰基)-O键的裂解具有出色的化学选择性.羧酸的c(酰基)-O键被2-氯-4,6-二甲氧基-1,3,5-三嗪(cdmt)活化形成三嗪酯中间体,该中间体进一步与氢硅烷反应在一个锅中生成醛两步过程.我们证明,与在相同反应条件下进行c(酰基)-N裂解相比,C(酰基)-O裂解/甲酰化可提供更高的收率和更宽的底物范围.
Doi:10.1002/adsc.202000794

专利信息

专利号:US-6284928-B1
优先权日:1999-02-23
标题 :Process for preparing intermediates useful in the synthesis of vitamin D compounds
发明人：DANIEWSKI ANDRZEJ ROBERT
权利人:HOFFMANN LA ROCHE
摘要:The invention relates to an improved process for preparing [(3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione]. (S)-(+)-2,3,7,7a-tetrahydro-7a-methyl-1H-indene-1,5(6H)-dione is reduced by reaction with diisobutylaluminum hydride and hexamethylphosphoric triaminde in the presence of a catalyst of the formula R—Cu, wherein R is n and R 1 , R 2 and R 3 are each, independently, selected from the group consisting of C 1-7 alkyl, phenyl, phenyl substituted by at least one C 1-4 alkyl group, benzyl, or benzyl substituted by at at least one C 1-4 alkyl group to form a reductate. The reductate is then treated with a bromine-containing electrophile to yield (3aR,4S,7aS)4-bromooctahydro-7a-methyl-1H-indene-1,5-dione.

专利号:CA-2298944-C
优先权日:1999-02-23
标 题 :Intermediates for synthesis of vitamin d

专利号:EP-1031552-B1
优先权日:1999-02-23
标 题 :Intermediates for the Synthesis of Vitamin D

专利号:EP-1031552-A1
优先权日:1999-02-23
标题:Intermediates for the Synthesis of Vitamin D

专利号:DE-60002242-T2
优先权日:1999-02-23
标题:Intermediates for the synthesis of vitamin D.

专利号:MX-PA00001800-A
优先权日:1999-02-23
标题:Intermediates for the synthesis of vitamin d