CAS: 94213-23-7; Lamotrigine Impurity C

上下游产品

2,3-dichlorobenzoyl cyanide aminoguanidine aminoguanidine bicarbonate

📜2,3-二氯苯甲酰腈,氨基胍碳酸氢盐置于crude Product,水,Sodium Hydroxide体系中,用 硫酸,乙腈 作为反应溶剂,化学反应 48.0H,以to Obtain 1.5 As A Yellow Solid In 66% Yield的收率获得产物(2Z)-2-[氰基(2,3-二氯苯基)亚甲基]脒基肼
参考文献:Compound And Its Use
标题:Compound And Its Use
摘要:一种测试拉莫三嗪样品或包含拉莫三嗪的药物剂量形式的纯度或稳定性降解的方法,包括对所述样品进行测定,以检测3-氨基-6-(2,3-二氯苯基)-1,2,4-三嗪-5-(4H)-酮(化合物a)和n-[5-氨基-6-(2,3-二氯苯基)-1,2,4-三嗪-3-基]-2,3-二氯苯甲酰胺(化合物b)中选择的化合物的存在.还公开了一种生产新型化合物b的方法.

专利信息

专利号:US-7390899-B2
优先权日:2002-09-20
标 题:Process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl) (1,2,4-triazine)
发明人：NEU JOZSEF; GIZUR TIBOR; TOERLEY JOZSEF; CSABAI JANOS; VEGH FERENC; KALVIN PETER; TARKANYI GABOR
权利人:RICHTER GEDEON VEGYESZET
摘要:The present invention relates to a new process for the synthesis of high purity 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of formula (I) using 2,3-dichlorobenzoyl cyanide and an aminoguanidine salt as starting materials. 2,3-dichlorobenzoyl cyanide is reacted with 1-2 mol equivalent of aminoguanidine salt in 3-6 mol equivalent of methanesulfonic acid, then the obtained adduct of formula (IV) is transformed without isolation into the product with magnesium oxide. In given case the obtained crude product can be recrystallized from a proper organic solvent

专利号:WO-2007069265-A1
优先权日:2005-12-12
标 题 :A novel process for the synthesis of lamotrigine and its intermediate
发明人：RAMAKRISHNAN ARUL; BHUSHAN VASANT DABHOLKAR; DINESH B DEORE
权利人:UNICHEM LAB LTD; RAMAKRISHNAN ARUL; BHUSHAN VASANT DABHOLKAR; DINESH B DEORE
摘要:This invention discloses a process for the preparation of 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine of a formula (I), commonly known as Lamotrigine which comprises the step of reacting aminoguanidine bicarbonarte and 2,3- dichlorobenzocynide with a reagent prepared by dissolving phosphorus pentoxide and methane sulfonic acid, to produce a novel intermediate 2-(2,3-dichlorophenyl)-2-(aminoguanidine)-acetonitrile monomesylate which is further cyclized to lamotrigine without basification.

专利号:US-2020335181-A1
优先权日:2018-01-09
标题:Digital reactionware
发明人：CRONIN LEROY
权利人:UNIV GLASGOW COURT
摘要:The invention provides a method for digitising a method of synthesis. The method includes the steps of identifying a method of synthesis for a target product; (ii) establishing a process sequence for that method, which process sequence is a collection of chemical and/or physical steps within the method of synthesis; and subsequently (iii) translating the process sequence to a digital model of the method of synthesis, which digital model comprises a digital description of the chemical and/or physical steps within the method of synthesis.