CAS: 91-59-8; 2-Naphthylamine

• ⚠️危险化学品目录(2015年版)致癌性,类别1A 《化妆品禁用原料目录》
• 英文名称2-Naphthylamine
• 中文名称2-萘胺
• IUPAC名称naphthalen-2-amine
• 其它别名2-Naphthalenamine; beta-Naphthylamine; Fast Scarlet Base B
• CAS编号91-59-8
• MFCD编号:MFCD00004112
• EINECS号:202-080-4
• FDA UNII编号:CKR7XL41N4
• 分子式:C10H9N
• 分子量:143.19
• 产品CID: 1953380
• 产品分类有机原料 → 氨基化合物 → 环烷胺、芳香单胺、芳香多胺及其衍生物和盐

• 相似结构搜索
• 产品信息参考;
• InChIKey: JBIJLHTVPXGSAM-UHFFFAOYSA-N
• InChI=1S/C10H9N/c11-10-6-5-8-3-1-2-4-9(8)7-10/h1-7H,11H2…
• 计算化学: 氢键受体数1.0氢键供体数1.0可旋转键数0.0

物理性质

• 熔点111-113  °C(文献)
• 沸点307.5±11.0 °C at 760 mmHg
• 闪点157.1±14.6 °C
• 密度1.1±0.1 g/cm3
• PH:Non& uorescence (2.8) to violet & uorescence (4.4)
• pKa:4.16(at 25°C)
• PSA:26.02
• LogP:2.17
• 折射率1.694
• 蒸汽压0.0±0.7 mmHg at 25°C
• 溶解性Solubility Soluble In Hot Water, Ethanol, Ether
• 敏感性1.稳定性 稳定2.禁配物 强氧化剂、酸类、酸酐3.聚合危害 不聚合4.分解产物 氨
• 外观形态粉红色至紫色粉末
• 储存条件-20°C 冷藏
• 产品应用萘胺的氨基与亚硝酸作用形成重氮盐,并可转烃成多种萘的衍生物,用于制造染料和有机合成,也用作有机分析试剂和荧光指标剂.
• 性质描述白色至淡红色叶片状结晶.熔点113°C,沸点306.1°C(294°C),相对密度1.0614(98/4°C).溶于热水,乙醇和乙醚,水溶液具有深蓝色荧光.能随水蒸气挥发.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08 & GHS07 & GHS09;
  注释: Health hazard & Exclamation mark & Environment
• 危险类别致癌性 类别1A
  急性毒性 类别4(经口)
  水生慢性毒性 类别2
  急性毒性 类别1(吸入)
  急性毒性 类别3(经皮)
  皮肤致敏 类别1
• 警示词Danger(危险)
• 危险描述H350 |可能致癌.
  H302 |吞咽有害.
  H411 |对水生生物有毒并具有长期持续影响.
  H330 |吸入致命.
  H311 |皮肤接触会中毒.
  H317 |可能引起皮肤过敏反应.
• 防范说明P201-P273-P301+P312+P330-P308+P313
• 危险等级6.1(a)
• UN编号1650.0
• 危险品标志T,N
• 包装等级II
• 安全声明53-45-61
• 危险类别码45-22-51/53
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 20937-86-4 = 91-59-8
  反应条件:1.1 Reagents: Formic Acid,Hantzsch Ester,Diisopropylethylamine Catalysts: 2242061-05-6 Solvents: Dichloromethane,Hexane; 38 H,Rt
  标题:Postmodification Of Supramolecular Organic Framework: Visible-Light-Induced Recyclable Heterogeneous Photocatalysis For Reduction Of Azides To Amines
  作者:Wu,Yi-Peng; Et Al
  参考文献:Chemical Communications (Cambridge 日期:2017 卷标:53(100) 页码:13367-13370]
  
  580-13-2 = 91-59-8
  反应条件:1.1 Reagents: Lithium Bis(Trimethylsilyl)Amide Catalysts: Bis(Triphenylphosphine)Nickel Dichloride Solvents: Toluene; 6 H,100 °C
  标题:Simple Nickel Salts For The Amination Of (Hetero)Aryl Bromides And Iodides With Lithium Bis(Trimethylsilyl)Amide
  作者:Martinez,Gabriel Espinosa; Et Al
  参考文献:Organometallics 日期:2018 卷标:37(18) 页码:2941-2944]
  
  580-13-2 = 91-59-8
  反应条件:1.1 Reagents: Ammonium Hydroxide Catalysts: Silica,Bis[2-(Mercapto-Ks)-N-[3-(Triethoxysilyl)Propyl]Acetamide]Palladium (Supported Onto Mesoporous Mcm-41); 18 H,Rt
  标题:Palladium 2-Mercapto-N-Propylacetamide Complex Anchored Onto Mcm-41 As Efficient And Reusable Nanocatalyst For Suzuki,Stille And Heck Reactions And Amination Of Aryl Halides
  作者:Nikoorazm,Mohsen; Et Al
  参考文献:Applied Organometallic Chemistry 日期:2016 卷标:30(10) 页码:843-851]
  
  135-19-3 = 91-59-8
  反应条件:1.1 Reagents: Ammonia,Sodium Pyrosulfite Solvents: Water; Rt -> 180 °C; 24 H,180 °C
  标题:One-Pot Synthesis Of Heteroatom-Bridged Cyclic Diaryliodonium Salts
  作者:Damrath,Mattis; Et Al
  参考文献:Organic Letters 日期:2022 卷标:24(13) 页码:2562-2566]
  
  612-55-5 = 91-59-8
  反应条件:1.1 Catalysts: (T-4)-Chlorotris(Triphenylphosphine)Cobalt,Bis[2-(Diphenylphosphino)Phenyl] Ether Solvents: Toluene; 20 Min,85 °C1.2 Reagents: Lithium Bis(Trimethylsilyl)Amide Solvents: Toluene; 12 H,100 °C1.3 Reagents: Hydrochloric Acid Solvents: Methanol,Water; 1 H,Rt
  标题:A Synthetic And Mechanistic Investigation Into The Cobalt(I) Catalyzed Amination Of Aryl Halides
  作者:Brennan,Marshall R.; Et Al
  参考文献:Chemical Science 日期:2014 卷标:5(12) 页码:4831-4839]
  
  = 91-59-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Iron Oxide (Fe3O4),Palladium; Rt -> 50 °C; 2 H,50 °C
  标题:Composite Of Ionic Liquid Decorated Cyclodextrin Nanosponge,Graphene Oxide And Chitosan: A Novel Catalyst Support
  作者:Sadjadi,Samahe; Et Al
  参考文献:International Journal Of Biological Macromolecules 日期:2019 卷标:122 页码:228-237]
  
  = 91-59-8
  反应条件:1.1 Reagents: Hydrogen Catalysts: Palladium,1H-Imidazolium,3-[4-[3-[3-(Ethoxydihydroxysilyl)Propyl]-1H-Imidazolium-1-Yl]But... (Silica-Supported) Solvents: Water; 12 H,303 K
  标题:Pd Nanoparticles In Ionic Liquid Brush: A Highly Active And Reusable Heterogeneous Catalytic Assembly For Solvent-Free Or On-Water Hydrogenation Of Nitroarene Under Mild Conditions
  作者:Li,Jing; Et Al
  参考文献:Acs Catalysis 日期:2011 卷标:1(6) 页码:657-664]
  
  581-97-5 = 91-59-8
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; 1 H,Rt -> Reflux; Reflux -> Rt1.2 Reagents: Sodium Hydroxide Solvents: Water; Ph 7
  标题:A Facile Method For Preparation Of 2-Naphthylamine
  作者:Wang,Qiu-Wen; Et Al
  参考文献:Huaxue Shiji 日期:2010 卷标:32(11) 页码:1033-1034]
  
  581-97-5 = 91-59-8
  反应条件:1.1 Reagents: Hydrochloric Acid Solvents: Ethanol,Water; Rt -> Reflux; 7 H,Reflux1.2 Reagents: Sodium Bicarbonate Solvents: Water; Neutralized
  标题:Palladium-Catalyzed Domino C-H/n-H Functionalization: An Efficient Approach To Nitrogen-Bridged Heteroacenes
  作者:Kamimoto,Natsuyo; Et Al
  参考文献:Chemistry - A European Journal 日期:2015 卷标:21(22) 页码:8257-8261]
  
  20937-86-4 = 91-59-8
  反应条件:1.1 Catalysts: 1,1′-Azobis(Cyclohexane-1-Carbonitrile) Solvents: Toluene; 15 Min,0 °C1.2 Reagents: Triethylsilane Catalysts: Tert-Dodecyl Mercaptan; 4 H,110 °C1.3 Solvents: Water
  标题:Radical Reduction Of Aromatic Azides To Amines With Triethylsilane
  作者:Benati,Luisa; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2006 卷标:71(15) 页码:5822-5825]
  
  20937-86-4 = 91-59-8
  反应条件:1.1 Reagents: Hantzsch Ester Catalysts: Palladium Solvents: Ethanol; 3 - 6 H,Reflux; Reflux -> Rt
  标题:Pd/c-Catalyzed Transfer Hydrogenation With Hantzsch Ester 1,4-Dihydropyridine For The Reduction Of Aromatic Azides,Aromatic Nitro Compounds And Olefins
  作者:Niu,Xiuqin; Et Al
  参考文献:Youji Huaxue 日期:2009 卷标:29(2) 页码:229-233]
  
  135-19-3 = 91-59-8
  反应条件:1.1 Reagents: Ammonium Hydroxide,Ammonium Sulfite Solvents: Water; 6 H,180 °C
  标题:Iron-Catalyzed Intramolecular Aminations Of C(Sp3)-H Bonds In Alkylaryl Azides
  作者:Alt,Isabel T.; Et Al
  参考文献:Angewandte Chemie 日期:2017 卷标:56(35) 页码:10582-10586]
  
  3857-83-8 = 91-59-8
  反应条件:1.1 Reagents: Tetrabutylammonium Bromide,Silanamine,1,1,1-Trimethyl-N-(Trimethylsilyl)-,Zinc Salt (2:1) Catalysts: Tri-Tert-Butylphosphine,Bis(Dibenzylideneacetone)Palladium Solvents: Tetrahydrofuran; 9 H,50 °C1.2 Reagents: Hydrochloric Acid Solvents: Diethyl Ether,Water; Neutralized
  标题:Zinc Trimethylsilylamide As A Mild Ammonia Equivalent And Base For The Amination Of Aryl Halides And Triflates
  作者:Lee,Dae-Yon; Et Al
  参考文献:Organic Letters 日期:2005 卷标:7(6) 页码:1169-1172]
  
  956484-66-5 = 91-59-8
  反应条件:1.1 Reagents: Trifluoroacetic Acid Solvents: Dichloromethane; Overnight,Rt
  标题:Fluorous-Tagged Carbamates For The Pd-Catalyzed Amination Of Aryl Halides
  作者:Trabanco,Andres A.; Et Al
  参考文献:Journal Of Organic Chemistry 日期:2007 卷标:72(21) 页码:8146-8148]
  
  612-55-5 = 91-59-8
  反应条件:1.1 Reagents: Ammonium Hydroxide Catalysts: Cuprous Iodide,Polyethylene Glycol; 12 H,130 °C; 130 °C -> Rt1.2 Reagents: Sodium Sulfate Solvents: Water
  标题:Simple And Convenient Copper-Catalyzed Amination Of Aryl Halides To Primary Arylamines Using Nh4Oh
  作者:Jung,Hee Seon; Et Al
  参考文献:Tetrahedron 日期:2016 卷标:72(40) 页码:5988-5993

海关参考信息

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• ➥ 防范代码详解
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