📜1-氯己烷,乙二胺 以 乙醇 作为反应溶剂,化学反应 24.0H,以44%的收率获得产物n-己基乙二胺
参考文献:Synthesis And Antitubercular Activity Of Lipophilic Moxifloxacin And Gatifloxacin Derivatives
标题:Synthesis And Antitubercular Activity Of Lipophilic Moxifloxacin And Gatifloxacin Derivatives
摘要:Fluoroquinolone (Fq) Has A Broad Spectrum Of Activity Against Several Bacteria,Mycobacteria,Parasites,And Other Diseases. Moxifloxacin And Gatifloxacin Are A New Generation Of Fluoroquinolone Agents With Improved Activity Against Gram-Negative And Positive Bacteria. As Lipophilicity Is An Important Consideration In The Design And Activity Of Novel Antibacterial Agents,We Report In This Work The Synthesis And Biological Evaluation Of 12 Lipophilic Moxifloxacin Or Gatifloxacin Derivatives,By Reaction Of 1-Cyclo-Propyl-6,7-Difluoro-1,4-Dihydro-8-Methoxy-4-Oxoquinoline-3-Carboxylic Acid 13 With Severals N-Monoalkyl 1,2-Ethanediamine Or 1,3-Propanediamine. (C) 2007 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2007.07.073