CAS: 6422-36-2; (S)-2-((S)-Pyrrolidine-2-Carboxamido)Propanoic Acid

上下游产品

(2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]propanoic acid (S)-benzyloxycarbonyl-proline acid chloride (S) tert-butyl 2-(((S)-1-methoxy-1-oxopropan-2-yl)carbamoyl)pyrrolidine-1-carboxylate 1-(tert-butoxycarbonyl)-L-prolineL-prolinamide (3S,8aS)-3-methylhexahydropyrrolo[1,2-a]pyrazine-1,4-dione

📜Z-Pro-Ala置于氢溴酸体系中,用 溶剂黄146 作为反应溶剂,以94%的收率获得产物脯氨酰丙氨酸
参考文献:Tomida,Ichiro; Kimura,Yoichi; Kudo,Ikuko,Agricultural And Biological Chemistry,1985,Vol. 49,# 2,P. 529-532
标题:Tomida,Ichiro; Kimura,Yoichi; Kudo,Ikuko,Agricultural And Biological Chemistry,1985,Vol. 49,# 2,P. 529-532

专利信息

专利号:EP-2676962-A1
优先权日:2012-06-21
标 题 :Derivatives of 1-aminoalkylphosphonate diaryl esters, method of 1-aminoalkylphosphonate diaryl ester derivatives preparation and their application
发明人：SIENCZYK MARCIN; GRZYWA RENATA; PIETRUSEWICZ EWA; OLEKSYSZYN JOZEF; WINIARSKI LUKASZ; BURSTER TIMO; BOEHM OTTO
权利人:UNIV ULM; WROCLAW UNIVERSITY OF TECHNOLOGY
摘要:The subject of the invention relates to 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl, and their use as inhibitors of serine proteases, and the low molecular weight molecular probes to detect the catalytically active forms of the enzymes. n A process for preparing 1-aminoalkylphosphonate diaryl esters of formula I, in which Bt represents biotin, W is a hydrocarbon linker chain of 5 to 10 carbon atoms, Y is the amino acid residues in an amount of 0 to 4, R is a substituent corresponding to the side chain of valine, alanine, leucine, phenylalanine, 4-guanidinephenylglycine, or 2-aminobutyric acid (Abu), X is the hydrogen or a compound selected from the group consisting of mercaptomethyl (S-methyl), methoxy (O-methyl), or carboxymethyl relies on application of triaryl phosphite, obtained from the phenol substituted at para position phosphorus (III) chloride in refluxing acetonitrile and is subjected to amidoalkylation reaction with benzyl carbamate and an aldehyde such as acetaldehyde, propionic aldehyde, iso -butyric aldehyde, phenylacetic aldehyde, p-nitrobenzoic aldehyde and isovaleric aldehyde, followed by the synthesis of hydrobromide salts of 1-aminoalkylphosphonate diaryl esters, in which the benzyloxycarbonyl (Cbz) protective group is removed, and in the next step is reacted with an amino acid containing protected α-amino group in the presence of a coupling reagent. The resulting phosphonic dipeptide containing tert-butoxycarbonyl (t-Boc) protective group is subjected to deprotection of α-amino group and obtained dipeptidyl 1-aminoalkylphosphonate diaryl ester is coupled with another amino acid with protected α-amino group, biotin or a derivative thereof in a manner analogous to that described above.

专利号:EP-2588602-A1
优先权日:2010-07-01
标题:Variants of glucoamylase
发明人：DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN
权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC
摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

专利号:WO-2011032360-A1
优先权日:2009-09-17
标 题:Momordica charantia peptide mc-jj2 and microwave promoted solid phase synthesis method thereof
发明人：HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
权利人:UNIV CHINA PHARMA; HUANG WENLONG; JIN JING; QIAN HAI; ZHANG HUIBIN; CHEN WEI; WANG JINGJIE; DU KUO
摘要:Provided are peptides MC-JJ2 and MC-JJ2163 from Momordica charantia with hypoglycemic activity and a microwave promoted solid phase synthesis method thereof. The peptides MC-JJ2 and MC-JJ2163 comprise the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 108, respectively.

专利号:US-2004171041-A1
优先权日:2001-05-22
标 题 :Preparation and use of single-stranded transcription substrates for synthesis of transcription products corresponding to target sequences

专利号:US-2007276142-A1
优先权日:2004-02-19
标题 :Catalytic Asymmetric Synthesis of Optically Active Alpha-Halo-Carbonyl Compounds

专利号:ES-2403154-T3
优先权日:1997-04-11
标 题 :Methods and compositions for the synthesis of long chain polyunsaturated fatty acids in plants