CAS: 5704-04-1; 2-((1,3-Dihydroxy-2-(Hydroxymethyl)Propan-2-yl)Amino)Acetic Acid

相似化合物

64431-96-5 6850-28-8 6976-37-0

羟基乙酰胺,三羟甲基氨基甲烷置于水体系中,用 甲醇 作为反应溶剂,60.0~94.0 °C,15.0 Kpa 条件下,反应 10.0H,反应生成 三(羟甲基)甲基甘氨酸
参考文献:一种三(羟甲基)甲基甘氨酸的制备方法
标题:一种三(羟甲基)甲基甘氨酸的制备方法
摘要:本发明涉及生物缓冲剂技术领域,公开了一种三(羟甲基)甲基甘氨酸的制备方法,包括如下制备步骤:将化合物i与化合物a进行反应,得到化合物ii;将上述的化合物ii进行水解反应,氧化反应,酸碱处理反应中的至少一种反应,得到三(羟甲基)甲基甘氨酸粗品,经过纯化后,得到三(羟甲基)甲基甘氨酸精品.本发明的制备方法中使用的原料成本低,操作简单,获得的产品纯度较高,不仅提高了产品的产率和降低了产品的应用成本,所得的产品符合生物缓冲剂领域对其纯度,杂质含量,成本等的要求,而且该方法适合工业化生产,适合于在生物缓冲剂领域的应用.

专利信息

专利号:US-4078331-A
优先权日:1976-04-28
标题:Process and culture composition for growth of alga and synthesis of biopolymer
发明人：SAVINS JOSEPH GEORGE; PAUL JAMES M
权利人:MOBIL OIL CORP
摘要:This specification discloses a process and a culture composition for growth of an alga and synthesis of biopolymer by the alga. The process involves growth of the alga and concomitant synthesis of the biopolymer in an aqueous culture containing as a source of phosphate for said alga dibasic sodium or dibasic potassium phosphate. The nitrogen source can be sodium nitrate or urea. Control of the pH of the culture is effected by injecting a mixture of carbon dioxide and air into the culture during growth of the alga and synthesis of the biopolymer. The carbon dioxide also serves as a source of carbon for growth of the alga and synthesis of the biopolymer and provides agitation/mixing within the culture chamber. Preferably, the mixture of carbon dioxide and air is injected continuously into the culture during the entire growth period of the alga.

专利号:US-6576447-B2
优先权日:2000-03-21
标 题:Method for synthesis of nucleic acids
发明人：TONOIKE HIROSHI
权利人:SHIMADZU CORP
摘要:An object of the present invention is to provide a novel method for suppressing the action of nucleic acid synthesis inhibitory substances and thereby amplifying a nucleic acid in a sample efficiently.According to the present invention, in a method for synthesis of nucleic acids to amplify an intended nucleic acid in a sample, the sample is brought in advance into contact with an insoluble polymer of a polyanion, a sulfated polymer or a sulfated polysaccharide, to remove nucleic acid synthesis inhibitory substances.

专利号:US-4078332-A
优先权日:1976-12-10
标题:Method and apparatus for the synthesis of alga biopolymer
发明人：SAVINS JOSEPH GEORGE
权利人:MOBIL OIL CORP
摘要:This specification discloses a method and apparatus for the synthesis of alga biopolymer. The method is comprised of two stages and involves subjecting an aqueous culture containing alga cells and nutrients required for the growth of the alga cells to a first stage of artificial illumination for a period of time such that growth of the alga and synthesis of biopolymer begins followed by a second stage of natural illumination provided by successive cycles of diurnal solar radiation and darkness. During the cycles of diurnal solar radiation and darkness in the second stage, the aqueous culture is continuously contacted with a mixture of carbon dioxide and air. Furthermore, during these cycles of diurnal solar radiation and darkness, the temperature of the aqueous culture is maintained at a level conducive to the growth of the alga cells. The apparatus is employed in the second stage and contains a lower chamber adapted to contain an aqueous thickening culture from a stage-one reactor. Means are provided for passing continually into the chamber and into contact with the aqueous culture a mixture of carbon dioxide and air. Means are also provided for maintaining the temperature of the aqueous culture at a level conducive to growth of the alga cells. There is also provided an upper chamber enclosed at the top portion thereof with a hemispherical radiant energy receiver capable of receiving incident solar radiation and being substantially transparent to the solar radiation. Conduit means are provided to transfer the aqueous culture from the lower chamber to the upper chamber. Means for impinging the aqueous culture upon the underside of the hemispherical radiant energy receiver are also provided. There are also provided means for returning the aqueous culture to the lower chamber from the upper chamber after impinging upon the underside of the hemispherical radiant energy receiver.

专利号:US-12208146-B2
优先权日:2018-11-19
标 题 :Reconstituted HDL nanoparticles for delivery of radioactive agents and uses thereof
发明人：LACKO ANDRAS G; PROKAI LASZLO; ISAAC-OLIVÉ KEILA
权利人:UNIV OF NORTH TEXAS HEALTH SCIENCE CENTER; THE AUTONOMOUS UNIV OF THE STATE OF MEXICO
摘要:Despite the widespread use of nanotechnology in radio-imaging applications, lipoprotein based delivery systems received only limited attention so far. The subject application provides for the synthesis of a novel hydrophobic radio-imaging tracer. This tracer, comprising a hydrazinonicotinic acid (HYNIC)-N-dodecylamide and 99mTc conjugate can be encapsulated into rHDL nanoparticles (NPs). These rHDL NPs can selectively target the Scavenger Receptor type B1 (SR-B1) that is overexpressed on most cancer cells due to excess demand for cholesterol for membrane biogenesis and thus can target tumors in-vivo. Details of the tracer synthesis, characterization of rHDL/tracer complex, in-vitro uptake, stability studies and in-vivo application of this new radio-imaging approach are provided.

专利号:US-6767723-B2
优先权日:2000-04-27
标题 :Method for synthesis of nucleic acids
发明人：TONOIKE HIROSHI
权利人:SHIMADZU CORP
摘要:An object of the present invention is to provide a method of treatment and a method of storage that are useful in conducting a nucleic acid synthesis procedure capable of directly amplifying an intended nucleic acid in a living body-derived sample without purification steps.The present invention provides a method for synthesis of nucleic acids in which a living body-derived sample itself is mixed with a reaction solution for gene amplification and allowed to react, which method comprises treating the sample with a surfactant before the reaction to destruct solid components such as cells or bacterial bodies containing nucleic acids and uniformly disperse them in the sample liquid.

专利号:US-5262312-A
优先权日:1990-04-25
标 题:Process for the glycosidase-catalyzed synthesis of glyco conjugates
发明人：HOLLA WOLFGANG; SCHUDOK MANFRED
权利人:HOECHST AG
摘要:It has been possible to show for a first time with the process according to the invention that the synthesis of glyco conjugates is possible by direct linkage of sugars with serine, serine derivatives and serine peptides with the aid of glucosidases.