CAS: 52421-75-7; 4-Ethyl-6-Hydroxy-2-Methylpyrimidine

该化合物是一种以二氢丙酰胺核心为主的环环有机化合物,对制药和农用化学研究具有重大兴趣,其结构是合成生物活性分子的多功能手架,特别是在发展钙导道调节器和抗微生物剂方面;乙基和甲基替代成分增强了其亲口性,可能提高生物利用率;该化合物因其能形成稳定的中间体而具有非对称合成和催化作用.高纯度和定义明确的再活动使其成为医药化学和材料科学应用的可靠建筑块.

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34126-99-3 6622-92-0 90565-53-0

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上下游产品

CAS号124-42-5 乙脒盐酸盐 | CAS号4949-44-4 丙酰基乙酸乙酯 | CAS号72324-46-0 6-Ethyl-2,2-dim... | CAS号74372-16-0 3-氧代戊酸酰胺 | CAS号89966-72-3 4-氯-6-乙基-2-甲基嘧啶 | CAS号82236-25-7 4-(1-chloroethy... | CAS号89966-73-4 4-ethyl-2-methy... | CAS号89966-75-6 4-ethyl-6-metho... | CAS号89966-77-8 6-ethyl-2-methy... | CAS号89966-78-9 6-ethyl-4-metho... | CAS号89966-83-6 2-(chloromethyl...

合成工艺路线路线简述

    📜6-乙基-2,2-二甲基-[1,3]二恶英-4-酮置于氨,Sodium Methylate体系中,用 甲醇,氯仿,Xylene 作为反应溶剂,化学反应 3.5H,反应生成 2-甲基-4-乙基-6-羟基嘧啶
    参考文献:Sato,Masayuki; Ogasawara,Hiromichi; Komatsu,Sachiko,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 10,P. 3848-3856
    标题:Sato,Masayuki; Ogasawara,Hiromichi; Komatsu,Sachiko,Chemical And Pharmaceutical Bulletin,1984,Vol. 32,# 10,P. 3848-3856

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    专利信息


    专利号:WO-2024103188-A1
    优先权日:2022-11-17
    标题 :Lin28 inhibitors and uses thereof
    发明人：DONG XUESEN; TCHERKASSOV ARTEM; RADAEVA MARIIA; HO CHIA-HAO
    权利人:UNIV BRITISH COLUMBIA
    摘要:This invention provides compound having the structure of Formula I: (I) and uses of such compounds for modulating Lin28 activity, which may target an interaction site between the Lin28 ZKD and the Letâ€?7 GGAG motif and prevent Lin28 from inhibiting Letâ€?7 synthesis. These Lin28 inhibitors are clinically useful drugs for cancer treatment, including prostate cancer as well as methods of treatment involving such compounds are also provide. Furthermore, the compounds described herein may be used for the treatment of Lin28 expressing cancers. The cancer may be selected from prostate, lung, brain, ovary, breast, cervix, endometrium, liver, colon, esophageal, pancreas, testis, bladder, kidney, and skin.

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    合成参考文献


    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 157.
    摘要:von Angerer, S., Science of Synthesis Knowledge Updates, (2011) 1, 168.
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