CAS: 5230-87-5; (1'R,3S,4'R,5'R,6A'R,7'R,9'R,9A'S)-1',5',6A',7'-Tetrahydroxy-5',9'-Dimethylhexahydrospiro[oxetane-3,6'-[4,9A]Methanocyclopenta[d]Oxocine]-2,2'(1'H)-Dione

上下游产品

18H24O8C18H24O8 21H32O6C21H32O6 20H30O7C20H30O7 21H34O8C21H34O8neoanisatin

专利信息

专利号:US-8119653-B2
优先权日:2006-07-07
标 题 :Belactosin derivatives as therapeutic agents/biological probes and their synthesis
发明人：ROMO DANIEL; CHO SUNG WOOK; SMITH JEFFREY W; RICHARDSON ROBYN D
权利人:ROMO DANIEL; CHO SUNG WOOK; SMITH JEFFREY W; RICHARDSON ROBYN D; TEXAS A & M UNIV SYS
摘要:Derivatives of belactosin and their synthesis are disclosed. In certain embodiments, compounds of the present invention exhibit anti-cancer, antiviral, antibiotic, and/or auto-immune therapeutic abilities. In general, methods of synthesis disclosed herein allow for introduction of a variety of substituents at numerous positions as well as the facile introduction of a beta-lactone ring moiety. The synthetic steps comprise, in preferred embodiments, a tandem Mukaiyama aldol lactonization reaction. Data demonstrating the utility of some of the derivatives as proteasome inhibitors is also disclosed.