CAS: 51077-16-8; Boc-Thz-Oh

相似化合物

63091-82-7 34592-47-7 444-27-9

上下游产品

CAS号24424-99-5 二碳酸二叔丁酯 | CAS号34592-47-7 L-硫代脯氨酸 | CAS号444-27-9 噻莫西酸 | CAS号50-00-0 甲醛 | CAS号52-90-4 L-半胱氨酸 | CAS号34592-47-7 L-硫代脯氨酸

📜L-硫代脯氨酸 反应生成 N-Boc-(R)-噻唑-4-羧酸
参考文献:Matsui,Takashi;Nagano,Mitsuo;Kitamura,Koichi;Shimizu,Fusaaki
标题:Matsui,Takashi;Nagano,Mitsuo;Kitamura,Koichi;Shimizu,Fusaaki

专利信息

专利号:WO-2024165450-A1
优先权日:2023-02-09
标题:Method of chemical synthesis of single-chain antibody fragments and products thereby obtained
发明人：FIGINI MARIANGELA; LUISON ELENA
权利人:GLYTECH INC; FIGINI MARIANGELA
摘要:A new method is disclosed for the protein full-chemical synthesis of single-chain antibody fragments (scFv); the obtained products are structurally close and functionally equivalent to their biological counterpart, being however, advantageously free of impurities and more reproducible in properties. The method includes the general steps of: (a) separately synthetizing sub-sequences (peptide fragments) (b) sequentially assembling the sub-sequences obtained in step (a) in the order as they appear in the target scFv amino acid sequence, and (c) performing oxidative folding of the assembled whole peptide molecule obtained in step (b) and dialyzing the resulting product in a buffer.

专利号:WO-03070764-A1
优先权日:2002-02-19
标题:Method for producing interferon
发明人：STRONG ANDREW EDWARD
权利人:RMF DICTAGENE SA; STRONG ANDREW EDWARD
摘要:The invention relates to a method for the chemical synthesis of interferon proteins containing one or more cysteine residues, by the native chemical ligation of segments of the full length interferon protein. The segments of the protein are selected based on the position of the cysteine residues in the interferon protein, with the position of the cysteine residue as a potential site of native chemical ligation. The full-length, fully deprotected polypeptide is folded into biologically active interferon protein by oxidation of the cysteine residues. The invention further relates to the production of the individual peptide fragments which act as intermediates in the synthesis of interferon-alpha. The present invention still further relates to groups of such peptide intermediates which can be utilized together to produce interferon-alpha and interferon-alpha-like proteins.

专利号:US-7662914-B2
优先权日:2001-06-05
标 题 :Native chemical ligation with three or more components
发明人：VILLAIN MATTEO; GAERTNER HUBERT
权利人:AMYLIN PHARMACEUTICALS INC
摘要:The invention provides a method of assembling oligopeptide intermediates in a native chemical ligation reaction that eliminates self-ligation of bi-functional intermediates. An important aspect of the invention is a bi-functional intermediate with an N-terminal cyclic thiazolidine protecting group which effectively prevents self-ligation in the chemical assembly process. The present invention is useful in methods for convergent synthesis of polypeptides and proteins and improves the efficiency of native chemical ligation reactions, particularly where three or more peptide fragments are used to assemble a polypeptide or protein product.

专利号:WO-2011151826-A2
优先权日:2010-06-01
标题:An expeditious synthesis of ubiquitinated peptide conjugates

专利号:EP-4414386-A1
优先权日:2023-02-09
标题 :Method of chemical synthesis of single-chain antibody fragments and products thereby obtained

专利号:EP-2575849-A2
优先权日:2010-06-01
标 题:An expeditious synthesis of ubiquitinated peptide conjugates