CAS: 501907-61-5; Tert-Butyl (2,6-Dichloropyridin-4-yl)Carbamate

相似化合物

2587-02-2 175461-33-3 1044148-88-0

上下游产品

2,6-dichloropyridine-4-carboxylic acid tert-butyl alcoholtert-butyl alcohol4-(tert-butoxycarbonylamino)-2,6-dichloronicotinic acid 4-amino-2,6-dichloronicotinic acid d]pyrimidine7-chloro-4-ethoxy-2-methyl-5-phenyl-pyrido[4,3-d]pyrimidine t-butyl (S)-2-chloro-6-[1-(4-fluorophenyl)ethylamino]pyridin-4-yl-carbamate

📜柠嗪酸置于盐酸,氯化亚砜,Sodium Hydroxide,Sodium Nitrite,三氯氧磷体系中,用 二氯甲烷,水,甲苯 作为反应溶剂,化学反应生成 N-Boc-4-氨基-2,6-二氯吡啶
参考文献:4-氨基-2,6-二氯吡啶的制备方法
标题:4-氨基-2,6-二氯吡啶的制备方法
摘要:本发明涉及卤素取代吡啶胺类化合物特别是4‑氨基‑2,6‑二氯吡啶的制备方法,以2,6‑二羟基异烟酸为原料,经氯代反应,Curtius重排或进一步脱氨基保护基得到.本发明原料易得,收率高,杂质含量低,且避免使用易爆试剂叠氮化钠,可进一步应用于工业化生产.

专利信息

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.