CAS: 4101-32-0; 4',5'-Dimethoxy-2'-Nitroacetophenone

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CAS号204842-93-3 2,3,9,10-tetram... | CAS号7595-31-5 2-硝基-4,5-二甲氧基苯胺 | CAS号4101-30-8 2'-氨基-4',5'-二甲氧基苯乙酮 | CAS号3395-03-7 1,2-二甲氧基-4,5-二硝基苯 | CAS号33245-76-0 2-溴-1-(4,5-二甲氧基... | CAS号37942-55-5 (1S)-1-(2,3-dim... | CAS号4015-31-0 6,7-Dimethoxy-4...

📜香草乙酮置于硝酸,Potassium Carbonate体系中,用 丙酮 作为反应溶剂,化学反应 4.0H,反应生成 1-(4,5-二甲氧基-2-硝基苯基)乙酮
参考文献:使用异氰酸酯参与的多组分反应基于结构的新型4-(2-氟苯氧基)喹啉衍生物作为c-Met抑制剂的发现
标题:使用异氰酸酯参与的多组分反应基于结构的新型4-(2-氟苯氧基)喹啉衍生物作为c-Met抑制剂的发现
摘要:由于c-Met激酶与许多人类癌症的进展,不良的临床结果甚至耐药性密切相关,因此它已成为小分子抗肿瘤药开发的有希望的目标.在这项研究中,设计,合成和评估了两个新颖的系列的6,7-取代的4-(2-氟苯氧基)喹啉衍生物,它们包含α-酰氧基羧酰胺或α-酰氨基酰胺支架.针对c-Met激酶和四种癌细胞系(h460,Ht-29,Mkn-45和mda-Mb-231)的生物学活性.大多数目标化合物显示出中等至显着的效力,并具有对h460和ht-29癌细胞系的选择性.初步的结构活性关系表明,α-酰氧基羧酰胺或α-酰氨基酰胺作为5-原子连接体有助于抗肿瘤效力.在这些化合物中,化合物10M(c-Met Ic 50 = 2.43 Nm,多靶酪氨酸激酶抑制剂)对具有ic 50的h460,Ht-29和mda-Mb-231细胞系表现出最强的抑制活性0.14+/-0.03μm,0.20+/-0.02μm和0.42+/-0.03μm的活性分别是福瑞替尼的1
DOI:10.1016/j.Ejmech.2020.112241

专利信息

专利号:US-4490374-A
优先权日:1982-09-30
标 题:5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
发明人：BANDURCO VICTOR T; LEVINE SEYMOUR D; MULVEY DENNIS M; TOBIA ALFONSO J
权利人:ORTHO PHARMA CORP
摘要:The synthesis of substituted quinazolinones is described. The novel quinazolinones are renal vasodilators and thereby increase renal blood flow, and are useful as cardiovascular agents.

专利号:US-6384264-B1
优先权日:1997-12-24
标题:Photoactive materials applicable to imaging systems
发明人：DOS SANTOS CRISTIANO MARIA DE; DAVIES JOHN KYNASTON; DOWD SHARON; JOHNSTONE ROBERT ALEXANDER WAL; PRATT MICHAEL JOHN; WADE JOHN ROBERT
权利人:AGFA GEVAERT
摘要:Organic photoprecursors of amines are provided for use in photosensitive imaging systems, finding particular application in the preparation of lithographic printing plates. Said photoprecursors generate free amines on exposure to long wavelength UV or visible radiation, have high solubility in organic solvents, and include photolabile 2-nitrobenzyl functional groups. Methods for the synthesis of the photoprecursors are described, and the use of the said photoprecursors for the production of printing plates using both positive working and negative working techniques are discussed.

专利号:US-4631283-A
优先权日:1982-09-30
标 题:Ortho substituted dihydroxy-2(1H)quinazolinone-1-alkanoic acids
发明人：BANDURCO VICTOR T; LEVINE SEYMOUR D; MULVEY DENNIS M; TOBIA ALFONSO J
权利人:ORTHO PHARMA CORP
摘要:The synthesis of substituted quinazolinones is described. The novel quinazolinones are renal vasodilators and thereby increase renal blood flow, and are useful as cardiovascular agents.