📜6-羟基己酸甲酯置于chromium(Vi) Oxide,草酰氯,硫酸,N,N-二甲基甲酰胺体系中,用 二氯甲烷,水,丙酮 用作溶剂,化学反应 17.67H,反应生成甲基脂肪酰氯 参考文献:Binns,Falmai; Roberts,Stanley M.; Taylor,Alan,Journal Of The Chemical Society. Perkin Transactions I,1993,# 8,P. 899-904 标题:Binns,Falmai; Roberts,Stanley M.; Taylor,Alan,Journal Of The Chemical Society. Perkin Transactions I,1993,# 8,P. 899-904
专利号:US-5216005-A 优先权日:1989-03-15 标题:Immunosuppressive analogues and derivatives of succinylacetone 发明人:NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY 权利人:CETUS CORP 摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.
专利号:US-5173482-A 优先权日:1989-03-15 标 题 :Immunosuppressive analogues and derivatives of succinylacetone 发明人:NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY 权利人:CETUS CORP 摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.
专利号:US-4895872-A 优先权日:1989-03-15 标题:Immunosupressive analogues and derivatives of succinylacetone 发明人:NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPAPORT HENRY 权利人:CETUS CORP 摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.
专利号:US-5252603-A 优先权日:1989-03-15 标题 :Immunosuppressive analogues and derivatives of succinylacetone 发明人:NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY 权利人:CETUS CORP 摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n=1-6 R=CH3, CF3, -CO2RIV, RI, RII=H, F, CH3, or RIII=H, or tetrazolyl RIV=H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.
专利号:US-9402842-B2 优先权日:2012-04-13 标题:Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors 发明人:CUSHMAN MARK S; NGUYEN TRUNG X; CONDA-SHERIDAN MARTIN M; POMMIER YVES GEORGE 权利人:PURDUE RESEARCH FOUNDATION 摘要:The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.
专利号:US-4054740-A 优先权日:1974-12-24 标 题 :Hydroxybiotin 发明人:FIELD GEORGE FRANCIS 权利人:HOFFMANN LA ROCHE 摘要:This invention relates to a synthesis of biotin by the reduction of dehydrobiotin. The dehydrobiotin is prepared from 6-hydroxy-7-nitro-heptanoic acid methyl ester. Novel intermediates are also obtained by this synthesis.