CAS: 35444-44-1; Methyl 6-Chloro-6-Oxohexanoate

该化合物是一种反应式二氯化物衍生物,主要用作有机合成和聚合物生产的中间体,其主要优点包括核糖分泌物的高反应性,使生产聚酰胺,聚酯和其他特殊聚合物能够产生高效的串联反应.甲基酯组增加了有机溶剂的溶解性,便利了处理和反应控制.在合成高性能材料(如粘合剂和涂层)时,这种化合物特别受到重视,因为它能够形成稳定的线性聚合物链.在无水条件下适当储存对于防止水解至关重要.其多变性使得它成为细微化学和工业应用的首选.

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41624-92-4 1501-26-4 1490-25-1

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合成工艺路线路线简述

    📜6-羟基己酸甲酯置于chromium(Vi) Oxide,草酰氯,硫酸,N,N-二甲基甲酰胺体系中,用 二氯甲烷,水,丙酮 用作溶剂,化学反应 17.67H,反应生成甲基脂肪酰氯
    参考文献:Binns,Falmai; Roberts,Stanley M.; Taylor,Alan,Journal Of The Chemical Society. Perkin Transactions I,1993,# 8,P. 899-904
    标题:Binns,Falmai; Roberts,Stanley M.; Taylor,Alan,Journal Of The Chemical Society. Perkin Transactions I,1993,# 8,P. 899-904

    海关参考信息

    专利信息


    专利号:US-5216005-A
    优先权日:1989-03-15
    标题:Immunosuppressive analogues and derivatives of succinylacetone
    发明人:NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
    权利人:CETUS CORP
    摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

    专利号:US-5173482-A
    优先权日:1989-03-15
    标 题 :Immunosuppressive analogues and derivatives of succinylacetone
    发明人:NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
    权利人:CETUS CORP
    摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

    专利号:US-4895872-A
    优先权日:1989-03-15
    标题:Immunosupressive analogues and derivatives of succinylacetone
    发明人:NITECKI DANUTE E; MORELAND MARGARET; ALDWIN LOIS; LEVENSON COREY H; BRAUDE IRWIN; MARK DAVID F; RAPAPORT HENRY
    权利人:CETUS CORP
    摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n = 1-6 RIV = H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

    专利号:US-5252603-A
    优先权日:1989-03-15
    标题 :Immunosuppressive analogues and derivatives of succinylacetone
    发明人:NITECKI DANUTE E; ALDWIN LOIS; LEVENSON COREY H; MORELAND MARGARET; BRAUDE IRWIN; MARK DAVID F; RAPOPORT HENRY
    权利人:CETUS CORP
    摘要:Succinylacetone derived or related medicaments and methods of synthesis of the same are shown wherein the medicaments consists of succinylacetonyl-proline-PEG, succinylacetonyl-NH-PEG, or compounds that have the formula: wherein n=1-6 R=CH3, CF3, -CO2RIV, RI, RII=H, F, CH3, or RIII=H, or tetrazolyl RIV=H, or alkyl and that have immunosuppressive activity both in vivo and in vitro based on their activities in cellular immunologic assays and adjuvant induced arthritis in rats, respectively.

    专利号:US-9402842-B2
    优先权日:2012-04-13
    标题:Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors
    发明人:CUSHMAN MARK S; NGUYEN TRUNG X; CONDA-SHERIDAN MARTIN M; POMMIER YVES GEORGE
    权利人:PURDUE RESEARCH FOUNDATION
    摘要:The invention described herein pertains to the synthesis and use of certain N-substituted indenoisoquinoline compounds which inhibit the activity Tyrosyl-DNA Phosphodiesterase I (Tdp1) or Topoisomerase I (Top1) or both, or otherwise demonstrate anticancer activity. Also disclosed are novel N-substituted indenoisoquinoline compounds and pharmaceutical compositions comprising the novel N-substituted indenoisoquinoline compounds.

    专利号:US-4054740-A
    优先权日:1974-12-24
    标 题 :Hydroxybiotin
    发明人:FIELD GEORGE FRANCIS
    权利人:HOFFMANN LA ROCHE
    摘要:This invention relates to a synthesis of biotin by the reduction of dehydrobiotin. The dehydrobiotin is prepared from 6-hydroxy-7-nitro-heptanoic acid methyl ester. Novel intermediates are also obtained by this synthesis.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Williams, A. C.; Camp, N., Science of Synthesis, (2003) 14, 450.
    摘要:Glass, R. S., Science of Synthesis, (2005) 22, 117.
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