CAS: 312756-74-4; 3-(N-Benzylsulfamoyl)-4-Bromo-N-(4-Bromophenyl)Benzamide
- 英文名称3-(N-Benzylsulfamoyl)-4-Bromo-N-(4-Bromophenyl)Benzamide
- 中文名称4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
- IUPAC名称3-(N-benzylsulfamoyl)-4-bromo-N-(4-bromophenyl)benzamide
- 其它别名4-Bromo-N-(4-Bromophenyl)-3-[[(Phenylmethyl)Amino]Sulfonyl]Benzamide; Rad51-Stimulatory Compound-1, Rs-1; Rad51-Stimulatory Compound 1; Rs-1; Rs1; Rs 1; Rs-1 - Rad51-Stimulatory Compound-1; 3-Benzylsulfamoyl-4-Bromo-N-(4-Bromophenyl)Benzamide
- CAS编号312756-74-4
- MFCD编号:MFCD00348720
- EINECS号:683-710-9
- 分子式:C20H16Br2N2O3S分子量:524.23
- 产品CID: 1300940
- 产品分类有机原料 → 苯类化合物 → 苯和取代衍生物
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
4-Bromobenzoic acid 3-benzylsulfamoyl-4-bromobenzoic acid 4-bromo-aniline合成工艺路线路线简述
📜4-溴苯甲酸置于氯磺酸,草酰氯体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 28.25H,反应生成 4-溴-N-(4-溴苯基)-3-[[(苯基甲基)氨基]磺酰基]苯甲酰胺
参考文献: Methods Of Treating Cancer Using Rad51Small Molecule Stimulators[fr] Procédés De Traitement Du Cancer à L'Aide De Stimulateurs De Molécules Rad51Small
标题: Methods Of Treating Cancer Using Rad51Small Molecule Stimulators[fr] Procédés De Traitement Du Cancer à L'Aide De Stimulateurs De Molécules Rad51Small
摘要:通过给予刺激rad51活性的化合物来杀死或抑制癌细胞和肿瘤的生长,并治疗癌症的方法.过度表达rad51或在同源重组机制中存在其他不平衡的细胞特别容易成为rad51刺激剂的靶点.
海关参考信息
- 2912110000-甲醛
2912210000-苯甲醛
2924199090-其他无环酰胺 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-12416015-B2
优先权日:2017-09-15
标题:Multiplex production and barcoding of genetically engineered cells
发明人：ROY KEVIN; SMITH JUSTIN D; ST ONGE ROBERT P; STEINMETZ LARS M; HABER JAMES E
权利人:UNIV LELAND STANFORD JUNIOR; UNIV BRANDEIS
摘要:The present disclosure relates to multiplex production and phenotyping of genetically engineered cells using RNA-guided nucleases and genomic barcoding. In particular, high-throughput multiplex genome editing is achieved utilizing a system that facilitates precise genome editing at desired target chromosomal loci by homology directed repair. Integration of guide RNA and donor DNA sequences as a genomic barcode at a separate chromosomal locus allows identification, isolation, and massively-parallel validation of individual variants from a pool of transformants. Strains can be arrayed according to their precise genetic modifications, as specified by donor DNA incorporation in heterologous or native genes. The present disclosure further relates to a method of editing codons outside of canonical guide RNA recognition regions, which enables complete saturation mutagenesis of protein-coding genes, a marker-based internal cloning method, which removes background due to oligonucleotide synthesis errors and incomplete vector backbone cleavage, and a method of enhancing homology directed repair by active donor recruitment.
专利号:CN-113333017-B
优先权日:2021-05-18
标 题 :Preparation method and application of a biochar-assisted synthesis of bifunctional catalysts
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Mason JM, Logan HL, Budke B, Wu M, Pawlowski M, Weichselbaum RR, Kozikowski AP, Bishop DK, Connell PP. The RAD51-stimulatory compound RS-1 can exploit the RAD51 overexpression that exists in cancer cells and tumors. Cancer Res. 2014 Jul 1;74(13):3546-55. doi: 10.1158/0008-5472.CAN-13-3220.
合成参考文献
参考文献:10.1016/j.bmcl.2014.04.088
摘要:Huang F, Mazin AV. Targeting the homologous recombination pathway by small molecule modulators. Bioorganic & Medicinal Chemistry Letters. 2014 Jul;24(14):3006–13. doi: 10.1016/j.bmcl.2014.04.088.
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