CAS: 20938-74-3; 2-Mercapto-N-Methylacetamide

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CAS号2365-48-2 巯基乙酸甲酯 | CAS号74-89-5 氨基甲烷 | CAS号88419-01-6 3-phenacyl-1,3-... | CAS号88419-02-7 3-[2-(4-bromoph... | CAS号1113-02-6 氧化乐果 | CAS号60-51-5 乐果 | CAS号623-51-8 巯基乙酸乙酯 | CAS号19788-48-8 Mercaptoacetic ... | CAS号147123-48-6 3-Amino-N-methy...

📜巯基乙酸甲酯,甲胺 反应生成N-甲基-硫代乙酰胺
参考文献:Cs2Co3催化的硫醇与膦酸酯和芳烃的需氧氧化交叉脱氢偶联
标题:Cs2Co3催化的硫醇与膦酸酯和芳烃的需氧氧化交叉脱氢偶联
摘要:描述了使用分子氧作为氧化剂的高效cs 2 Co 3催化的硫醇与膦酸酯和芳烃的氧化偶联.这些反应不仅提供了一种新颖的碱金属盐催化的好氧氧化反应,而且提供了一种在制药和农药中普遍发现的硫代磷酸盐和亚硫基芳烃的有效方法.该反应在简单温和的反应条件下进行,可耐受各种官能团,适用于生物活性分子的后期合成和修饰.
Doi:10.1002/anie.201612190

专利信息

专利号:EP-0097994-B1
优先权日:1982-06-24
标 题:Method for the solid-phase synthesis of retro-inverso polypeptides
摘要:This invention relates to a method for the solid-phase synthesis of polypeptides containing retro-inverted peptide bonds, using polydimethylacrylamide-co-acryloylsarcosimethylester resin cross-linked with N, N min -ethylene-bis-acrylamide as the insoluble support for lengthening the polypeptide chain in stages by the addition of suitable amino acid derivatives and/or peptides in succession. In particular, the method described in the present invention allows the easy preparation, on the polymer matrix, of monoacylated gem-diamino residues using the reagent I, I-bis (trifluoroacetoxy) iodobenzene in mixed aqueous-organic solvents.

专利号:US-4774319-A
优先权日:1985-03-06
标题:Synthesis of a derivative of GRF and intermediate peptides
发明人：ONO KEIICHI; KAI YOSHIYUKI; TAKEBAYASHI YOSHIAKI; SANO AKIHIKO; SUWA KAZUSHI
权利人:SUMITOMO PHARMA
摘要:A process for the manufacture of a polypeptide (I) having the formula: ##STR1## which comprises steps of: (a) coupling, successively and in the order of the sequence of the polypeptide (I), the four protected fragments A, B, C and D or five protected fragments A, B, C, E and F, n said fragment A by the formula, Leu-Gin-Asp-Ile-Met-Ser-Arg-NH 2 n said fragment B by the formula, Gln-Leu-Ser-Ala-Arg-Lys-Leu n said fragment C by the formula, Arg-Lys-Val-Leu-Gly n said fragment D by the formula, Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr n said fragment E by the formula, Ile-Phe-Thr-Asn-Ser-Tyr n and said fragment F by the formula, Tyr-Ala-Asp-Ala being represented, respectively, and n (b) eliminating, at the end of sequence, all the protecting groups to provide the polypeptide (I) which is active on the stimulation of the release of the growth hormone and thus is very useful as medicine for treatment of growth hormone deficiency disease and the like.

专利号:US-9303041-B2
优先权日:2012-08-21
标题 :Haptens of olanzapine
发明人：DONAHUE MATTHEW GARRETT; GONG YONG; SALTER RHYS; HRYHORENKO ERIC; DECORY THOMAS R; REMMERIE BART; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV; ORTHO CLINICAL DIAGNOSTICS INC
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from olanzapine. The invention also relates to conjugates of an olanzapine hapten and a protein.

专利号:US-9795685-B2
优先权日:2012-08-21
标 题 :Haptens of aripiprazole
发明人：LIN RONGHUI; SALTER RHYS; DECORY THOMAS R; HRYHORENKO ERIC; REMMERIE BART M; SANKARAN BANUMATHI
权利人:JANSSEN PHARMACEUTICA NV
摘要:The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.

专利号:US-6972320-B2
优先权日:2000-05-12
标题 :Ligation method and reagents to form an amide bond
发明人：RAINES RONALD T; KIESSLING LAURA L; NILSSON BRADLEY L
权利人:WISCONSIN ALUMNI RES FOUND
摘要:Methods and reagents for the formation of amide bonds between an activated carboxylic acid derivative and an azide useful in the synthesis of peptides, proteins and derivatized or labeled amino acids, peptide or proteins. The method involves the formation of a phosphinothioester which reacts with an azide resulting in amide formation. The invention provides phosphinothiol reagents which convert activated carboxylic acid derivatives to phosphinothioesters which then react with azides to form an amide bond. The methods and reagents of the invention can be used for stepwise synthesis of peptides on solid supports or for the ligation to two or more amino acids, two or more peptide or two or more protein fragments.

专利号:EP-0193910-A2
优先权日:1985-03-06
标题:Synthesis of a derivative of GRF and intermediate peptides