CAS: 204656-20-2; (2S)-5-[[(5S)-5-[[(2S)-2-[[(2S)-2-[[(2S)-5-Amino-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(1H-Imidazol-5-yl)Propanoyl]Amino]Propanoyl]Amino]-4-Carboxybutanoyl]Amino]Acetyl]Amino]-3-Hydroxybutanoyl]Amino]-3-Phenylpropanoyl]Amino]-3-Hydroxybutanoyl]Amino]-3-Hydroxypropanoyl]Amino]-3-Carboxypropanoyl]Amino]-3-Methylbutanoyl]Amino]-3-Hydroxypropanoyl]Amino]-3-Hydroxypropanoyl]Amino]-3-(4-Hydroxyphenyl)Propanoyl]Amino]-4-Methylpentanoyl]Amino]-4-Carboxybutanoyl]Amino]Acetyl]Amino]-5-Oxopentanoyl]Amino]Propanoyl]Amino]Propanoyl]Amino]-6-[[(2S)-1-[[(2S)-1-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-5-Carbamimidamido-1-[[2-[[(2S)-5-Carbamimidamido-1-(Carboxymethylamino)-1-Oxopentan-2-Yl]Amino]-2-Oxoethyl]Amino]-1-Oxopentan-2-Yl]Amino]-3-Methyl-1-Oxobutan-2-Yl]Amino]-4-Methyl-1-Oxopentan-2-Yl]Amino]-3-(1H-Indol-3-yl)-1-Oxopropan-2-Yl]Amino]-1-Oxopropan-2-Yl]Amino]-3-Methyl-1-Oxopentan-2-Yl]Amino]-1-Oxo-3-Phenylpropan-2-Yl]Amino]-4-Carboxy-1-Oxobutan-2-Yl]Amino]-6-Oxohexyl]Amino]-2-(Hexadecanoylamino)-5-Oxopentanoic Acid

专利信息

专利号:WO-2023012709-A1
优先权日:2021-08-05
标 题 :An improved process for fmoc synthesis of semaglutide
发明人：LOBO LESTER JOHN; CHANDRAKESAN MURALIDHARAN; DOSHI CHETAN; CHANADAK SHAILESH LALCHAND; YADAV NANDLAL GOPAL; MOHE NIKHIL UMESH; VISHWANATHAN KODANDARAMAN
权利人:USV PRIVATE LTD
摘要:The present invention relates to an improved process for the synthesis of glucagon-like-peptide-1 (GLP-1) and its analogs by using combination of solid and solution phase synthesis of Fmoc protected amino acids in a sequential manner, optionally incorporating Boc protected dipeptide for unnatural amino acid in the Sequence of GLP-1, cleaving GLP-1 sequence from the resin followed by purification; attaching side-chain to the desired amino acid in the solution phase to synthesize desired GLP-1 analog, purifying it to Semaglutide. Temperature gradient is applied during initial coupling of amino acids to facilitate completion of difficult coupling reactions.

专利号:US-12351573-B2
优先权日:2019-05-09
标 题:Compounds for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; CHENG KAI FAN
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Synthesis of O-benzotriazole and O-imidazole synthons are described. Uses of synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the synthons and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2023159450-A1
优先权日:2020-05-08
标 题 :Dimers for use in synthesis of peptidomimetics
发明人：AL-ABED YOUSEF; ALTITI AHMAD
权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH
摘要:Dimers for use in synthesis of peptidomimetics are described. Uses of dimers as synthons in synthesis of azapeptides and other peptidomimetics, azapeptides and other peptidomimetics synthesized from the dimers and uses of azapeptides and other peptidomimetics are also described.

专利号:US-2019177392-A1
优先权日:2014-09-23
标 题 :Synthesis of glp-1 peptides
发明人：PENIAS NAVON SHARON; NAVEH SHIRLY; VASILEIOU ZOI; BARLOS KONSTANTINOS
权利人:NOVETIDE LTD
摘要:Disclosed are processes for the synthesis of GLP-1 peptides, such as liraglutide and semaglutide, and a process for purifying liraglutide.

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:WO-2024261319-A1
优先权日:2023-06-23
标题 :Methods of chemical synthesis of peptides
发明人：AL MUSAIMI OTHMAN; WILLIAMS DARYL ROBERT
权利人:IMPERIAL COLLEGE INNOVATIONS LTD
摘要:The present invention relates to methods for the synthesis of peptides and related compounds supported on a solid polymeric resin. The inventive method provides synthetic schemes that permit the coupling of two or more peptide fragments attached to the same polymeric support, in a fashion that allows access to previously unobtainable structures, and provides a more convenient and higher-yielding approach to known peptides, including those of commercial significance.