CAS: 20347-71-1; 2-(3,4-Dihydroxyphenyl)-2-((2-(3,4-Dihydroxyphenyl)-5,7-Dihydroxychroman-3-yl)Oxy)Chroman-3,4,5,7-Tetraol

专利信息

专利号:US-7126014-B2
优先权日:2000-09-05
标题 :Synthesis of epecatechin-4α, 8-epicatechin and -catechin dimers and derivatives thereof
发明人：KOZIKOWSKI ALAN P; ROMANCZYK JR LEO J; TUECKMANTEL WERNER
权利人:MARS INC
摘要:Oligomeric procyanidins containing 4α-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4α,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen/metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the β face.

专利号:US-7339065-B2
优先权日:2003-07-21
标题 :Design and synthesis of optimized ligands for PPAR
发明人：AVERY MITCHELL A; PERSHADSINGH HARRIHAR A
权利人:BETHESDA PHARMACEUTICALS INC; UNIV MISSISSIPPI
摘要:This invention provides new chemical entities useful for treating a variety of clinical disorders including those that are influenced by the activity of peroxisome proliferator activated receptors (PPAR). The structures of the compounds and methods to design, make and use the compounds are provided. Compounds and methods for administering therapeutic compositions comprising the compounds in cases of the disease psoriasis are provided. An exemplary compound having the formula compound is 5adamantan-2-yl-pentanoic acid {2-[4-(2,4-dioxo-thiazolidin-5-yl-methyl)-phenoxy]-ethyl}-methyl-amide is provided.

专利号:EP-1921076-A1
优先权日:2002-10-11
标题:systhesis of procyanidin B2
发明人：CASTILLO GERARDO M; NGUYEN BETH P; CHOI PAULA Y; LARSEN LESLEY; LORIMER STEPHEN D; SNOW ALAN D
权利人:PROTEOTECH INC
摘要:Methods for the synthesis of procyanidin B2 are disclosed. The synthetic methods utilize epicatechin as a starting material and produce procyanidin BZ in high yields.

专利号:US-7531717-B2
优先权日:2000-07-28
标题:Regulatory genes involved in condensed tannin synthesis in plants
发明人：GRUBER MARGARET Y; RAY HEATHER
权利人:CA MINISTER AGRICULTURE & FOOD
摘要:The present invention provides two novel regulatory genes and encoded proteins which can be used to alter the biosynthesis and accumulation of condensed tannin levels in plants and plant tissues. The present invention further encompasses transgenic constructs containing the novel regulatory genes herein referred to as Ulimyc, Corniculmyc and Japmyc, for use in the transformation of plants and plant tissues and transgenic plants containing such constructs. The identification and characterization of these novel genes provide a mechanism for altering tannin production in plants and allows one to alter such levels to produce a variety of benefits in the field of agriculture, land reclamation animal farming and food technology in general.

专利号:US-2005020512-A1
优先权日:2002-10-02
标 题:Synthesis of oligomeric epicatechin and catechin-derived procyanidins

专利号:US-2003100775-A1
优先权日:2000-09-05
标 题 :Synthesis of 4alpha-arylepicatechins