CAS: 1647-23-0; 1-Bromo-3,3-Dimethylbutane

相似化合物

1498334-29-4 6570-95-2 6188-50-7

📜3,3-二甲基-1-丁酸置于lithium Aluminium Tetrahydride,三溴化磷体系中,用 四氢呋喃,乙醚 用作溶剂,化学反应 16.0H,反应生成3,3-二甲基-1-溴丁烷 [1647-23-0]
参考文献:[1,3,4]噻二唑[3,2-A]-1,2,3-三唑并[4,5-D]嘧啶-9(3H)-One衍生物的合成及抗过敏活性.二.6-烷基和6-环烷基烷基衍生物.
标题:[1,3,4]噻二唑[3,2-A]-1,2,3-三唑并[4,5-D]嘧啶-9(3H)-One衍生物的合成及抗过敏活性.二.6-烷基和6-环烷基烷基衍生物.
摘要:一系列的6-烷基或6-(环烷基烷基)-[1,3,4]噻二唑[3,2-A]-1,2,3-三唑[4,5-D]嘧啶-9(3H)-由相应的1,3,4-噻二唑-5-胺3B-O合成1B-O,并评估产物的抗过敏活性.在化合物6-(2-环己基乙基)-[1,3,4]噻二唑[3,2-A]-1,2,3-三唑并[4,5-D]嘧啶-9(3H)-1H中发现其x射线晶体学立体结构是一种有前途的新型抗过敏药,具有低毒性和双重活性,可作为白三烯d4受体拮抗剂和口服活性肥大细胞稳定剂.
Doi:10.1248/cpb.40.2391

专利信息

专利号:US-8268936-B2
优先权日:2005-01-04
标题:Synthesis of hybrid block copolymers and uses thereof
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and methods of preparing the same.

专利号:US-2012196989-A1
优先权日:2005-02-11
标题:Synthesis of homopolymers and block copolymers
发明人：BREITENKAMP KURT; SILL KEVIN N
权利人:BREITENKAMP KURT; SILL KEVIN N; INTEZYNE TECHNOLOGIES INC
摘要:The present invention relates to the field of polymer chemistry and more particularly to homopolymers and block copolymers and methods of preparing the same.

专利号:WO-9966934-A1
优先权日:1998-06-22
标 题 :CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6774125-B2
优先权日:1998-06-22
标 题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6509331-B1
优先权日:1998-06-22
标题:Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：AUDIA JAMES E; THOMPSON RICHARD C; WILKIE STEPHEN C; BRITTON THOMAS C; PORTER WARREN J; HUFFMAN GEORGE W; LATIMER LEE H
权利人:ELAN PHARM INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit beta-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits beta-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-7390801-B2
优先权日:1996-12-23
标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.