CAS: 1632-84-4; 4-(Methylthio)Phenylisocyanate

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CAS号123-09-1 4-氯茴香硫醚 | CAS号917-61-3 氰酸钠 | CAS号86764-40-1 1,1-dibenzyl-3-...

📜N-Hydroxy-4-Methylsulfanylbenzamide置于carbonyldiimidazole体系中,用 乙腈 用作溶剂,化学反应 0.5H,反应生成异氰酸-4(甲硫基)苯酯
参考文献:羰基二咪唑介导的丢失重排
标题:羰基二咪唑介导的丢失重排
摘要:发现羰基二咪唑(cdi)介导各种异羟肟酸的洛森重排为异氰酸酯.该过程在实验上是简单且温和的,咪唑和co 2是唯一的化学计量副产物.对于大规模应用而言意义重大,该方法避免了使用有害试剂,因此是curtius和hofmann重排标准处理条件的绿色替代方案.
Doi:10.1021/ol9023387

专利信息

专利号:WO-9700244-A1
优先权日:1995-06-19
标题 :Process for parallel synthesis of a non-peptide library
发明人：FRITZ JAMES E; KALDOR STEPHEN W
权利人:LILLY CO ELI; FRITZ JAMES E; KALDOR STEPHEN W
摘要:A process for the sequential preparation of a library of compounds having pharmaceutical usage. The process involves the sequential mixing of solution phase reagents, followed by scavenging of excess unreacted reagents with solid phase scavenging agents. The process is highly iterative and applicable for producing various ureas, thiureas, amides, carbonates and tertiary amines.

专利号:US-2008280877-A1
优先权日:2007-05-10
标 题:Azetidines
发明人：DACK KEVIN NEIL; SKERRATT SARAH ELIZABETH; YEAP SIEW KUEN
权利人:PFIZER
摘要:The invention relates to EP2 antagonist azetidines of formula (I) n n n n n n n n n n wherein Ar, R 1 , X, and Z are as defined herein, to their use in medicine, particularly in the treatment of endometriosis and/or uterine fibroids, to intermediates useful in their synthesis, and to compositions containing them.

专利号:RU-2170231-C2
优先权日:1994-09-29
标 题:Imidazolidines substituted with heterocycle, method of their synthesis and pharmaceutical compositions containing thereof

专利号:KR-19980076014-A
优先权日:1997-04-04
标 题 :Synthesis method of hydridein derivative using solution phase and solid phase reaction