CAS: 145100-50-1; 1,1,1-Trifluoro-N-(Pyridin-2-yl)-N-((Trifluoromethyl)Sulfonyl)Methanesulfonamide

相似化合物

145100-51-2 2230820-23-0 1353992-35-4

上下游产品

CAS号504-29-0 2-氨基吡啶 | CAS号358-23-6 三氟甲磺酸酐 | CAS号123994-49-0 3,4-dihydronaph... | CAS号945761-93-3 1H-吲唑-7-三氟甲基磺酸 | CAS号63028-10-4 cyclohexa-1,5-d...

2-氨基吡啶,三氟甲磺酸酐置于吡啶体系中,用 4-(Dicyanomethylene)-2-Methyl-6-(P-Dimethylaminostyryl)-4H-Pyran 用作溶剂,以50.66%的收率获得2-[n,N-双(三氟甲烷烷磺酰)氨基]吡啶
参考文献: Heterocyclic Compounds As Triggering Receptor Expressed On Myeloid Cells 2 Agonists And Methods Of Use[fr] Composés Hétérocycliques Utilisés En Tant Que Récepteur De Déclenchement Exprimé Sur Des Agonistes De Cellules Myéloïdes 2 Et Procédés D'Utilisation
标题: Heterocyclic Compounds As Triggering Receptor Expressed On Myeloid Cells 2 Agonists And Methods Of Use[fr] Composés Hétérocycliques Utilisés En Tant Que Récepteur De Déclenchement Exprimé Sur Des Agonistes De Cellules Myéloïdes 2 Et Procédés D'Utilisation

专利信息

专利号:US-9994508-B2
优先权日:2012-12-11
标 题:Versatile and functionalised intermediates for the synthesis of vitamin D and novel vitamin D derivatives
发明人：LOPEZ PEREZ BORJA; SIGUEIRO PONTE RITA; MAESTRO SAAVEDRA MIGUEL A; MOURINO MOSQUERA ANTONIO
权利人:ENDOTHERM GMBH
摘要:Novel intermediates for the complete synthesis of vitamin D are provided that allow a great versatility of functional groups in the final vitamin derivatives. Vitamin derivatives that are epimeric in position 3 and vitamin derivatives with a wide range of functionalities in position 18, including compounds with isotopic labelling are provided.

专利号:US-2024309003-A1
优先权日:2021-05-04
标题 :Heterocyclic compounds as triggering receptor expressed on myeloid cells 2 agonists and methods of use
发明人：HOUZE JONATHAN B; BOS MAXENCE; MANCUSO JOHN; FRANZONI IVAN; PANDYA BHAUMIK; KAPLAN ALAN
权利人:VIGIL NEUROSCIENCE INC
摘要:The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2â€?). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

专利号:US-2011319644-A1
优先权日:2006-11-02
标 题:Process for production of 1-hydroxy-19-norcyclovitamin d derivative and intermediate for the production
发明人：TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
权利人:TOYODA ASAKO; NAGAI HAZUKI; KONUKI KANAME; TSUCHIDA TOSHIO
摘要:A cyclovitamin D derivative produced from 25-hydroxyvitamin D is reacted with osmium tetraoxide or a permanganic acid salt to produce a 10,19-diolcyclovitamin D derivative. The 10,19-diolcyclovitamin D derivative is reacted with a perhalogenic acid salt or lead tetraacetate to produce a 10-oxocyclovitamin D derivative. A 1-hydroxycyclovitamin D derivative is produced from the 10-oxocyclovitamin D derivative via a cyclovitamin D derivative and a 1,10-olefincyclovitamin D derivative. The 1-hydrocyclovitamin D derivative is subjected to solvolysis, thereby producing a 1-hydroxy-19-norviatmin D derivative. Thus provided are a novel process for production of 1-hydroxy-19-norcyclovitamin D derivative that is utilizable as an intermediate in the synthesis of 1-hydroxy-19-norvitamin D derivative which is useful as a pharmaceutical agent; and an intermediate for the production.

专利号:US-9650410-B2
优先权日:2013-07-29
标题:Process for the preparation of abiraterone and abiraterone acetate
发明人：LENNA ROBERTO; DI BRISCO RICCARDO
权利人:IND CHIMICA SRL
摘要:The present invention relates to a novel process for the synthesis of abiraterone, and in particular of abiraterone acetate, compound of formula (I) reported below: N O (I) which has pharmacological activity useful for slowing down the progression of prostate cancer at an advanced stage. The process is characterized by an intermediate step wherein DHEA-acetate is triflated using Ar—N(OTf) 2 as the triflation reagent.

专利号:US-9676815-B2
优先权日:2013-07-29
标题:Process for the preparation of abiraterone or abiraterone acetate
发明人：LENNA ROBERTO; DI BRISCO RICCARDO
权利人:IND CHIMICA SRL
摘要:The present invention relates to a novel process for the synthesis of abiraterone and in particular abiraterone acetate, a compound of formula (I) reported below: having pharmacological activity suitable for slowing down the progression of advanced stage prostate cancer. The process is characterized by the fact that the intermediate triflation step is carried out on prasterone (DHEA) or its 3-acetate using Ar—N(OTf) 2 as the triflation reagent, but where Ar is not phenyl, and by the fact that the base used in this step is an alkali metal alcoholate.

专利号:ES-2396524-A1
优先权日:2012-12-11
标题 :Versatile and functionalized intermediates in the synthesis of vitamin D and new vitamin D derivatives