CAS: 1346528-50-4; N-(4-Chloropyridin-3-yl)-4-((2,2-Difluorobenzo[d][1,3]Dioxol-5-yl)Methyl)Piperazine-1-Carboxamide

上下游产品

1-[(2,2-二氟-1,3-苯并二氧杂环戊烷-5-基)-甲基]哌嗪 1-((2,2-Difluorobenzo[d][1,3]Dioxol-5-yl)Methyl)Piperazine 1093211-85-8

📜2,2-二氟-1,3-苯并二恶茂-5-甲醛置于20% Palladium Hydroxide-Activated Charcoal 吡啶,氢气体系中,用 甲醇,甲苯 用作溶剂,2.0~70.0 °C,101.33 Kpa 条件下,反应 58.5H,反应生成N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺
参考文献: Modulators Of Fatty Acid Amide Hydrolase[fr] Modulateurs De L'Amide Hydrolase D'Acide Gras
标题: Modulators Of Fatty Acid Amide Hydrolase[fr] Modulateurs De L'Amide Hydrolase D'Acide Gras
摘要:描述了4-(2,2-二氟苯并[1,3]二噁英-5-基甲基)-哌嗪-1-羧酸(4-氯吡啶-3-基)-酰胺,该化合物可用作faah调节剂.4-(2,2-二氟苯并[1,3]二噁英-5-基甲基)-哌嗪-1-羧酸(4-氯吡啶-3-基)-酰胺可用于制备药物组合物,并用于治疗由脂肪酰胺水解酶(Faah)活性介导的疾病状态,紊乱和情况,如焦虑,疼痛,炎症,睡眠障碍,进食障碍,能量代谢紊乱和运动障碍(例如多发性硬化).还公开了合成4-(2,2-二氟苯并[1,3]二噁英-5-基甲基)-哌嗪-1-羧酸(4-氯吡啶-3-基)-酰胺的方法.

专利信息

专利号:US-12194020-B2
优先权日:2017-12-22
标 题:Reversing baldness through cannabinoid receptor activation
发明人：POSTREL RICHARD
权利人:POSTREL RICHARD
摘要:This invention reverses male pattern baldness by shocking dormant hair follicles out of their androgen induced hibernation phase back to the active hair-growing anagenic phase. The invention integrates two functions: 1) It blocks synthesis of compounds holding the follicles in the telogenic/hibernating phase and 2) It stimulates synthesis of compounds animating the hair-growing/anagenic phase in the follicular activity cycle. One preferred embodiment comprises an enzyme inhibitor blocking the conversion of testosterone to dihydrotestosterone (DHT), a flavonoid simultaneously increasing synthesis of prostaglandins alternative to prostaglandin D2, and a selected cannabinoid compound stimulating restore the hair follicle to its normal growth cycle. This novel trimodal therapy restores the hair follicles to their normal cycling processes and maintains these restorative properties so long as this rebalance in maintained.