CAS: 118994-90-4; Oxazole-5-Carboxylic Acid

相似化合物

118994-89-1 127232-41-1 118994-86-8

上下游产品

噁唑-5-羧酸乙酯 Oxazol-5-Yl-Carboxylic Acid Ethyl Ester 118994-89-1

噁唑-5-羧酸乙酯置于lithium Hydroxide Monohydrate,盐酸体系中,用 水 用作溶剂,化学反应 7.5H,以87.4%的收率获得唑-5-羧酸
参考文献:C-h功能化在磷脂酰肌醇3-激酶delta抑制剂nemiralisib的聚合反应中的应用
标题:C-h功能化在磷脂酰肌醇3-激酶delta抑制剂nemiralisib的聚合反应中的应用
摘要:本文介绍了一种改进的可扩展方法,用于生产nemiralisib(一种磷脂酰肌醇-3-激酶δ抑制剂).结合三个连续的催化反应,包括钯催化的c-h功能化和铱催化的硼化反应,显着简化并缩短了合成顺序.修订后的路线已在多千克规模的中试工厂中成功实施,以交付大于100千克的产品.
Doi:10.1021/acs.Oprd.0C00486

专利信息

专利号:US-8080669-B2
优先权日:2006-05-12
标题:Process for the synthesis of 2-aminoxazole compounds
发明人：BENJAHAD ABDELLAH
权利人:BENJAHAD ABDELLAH; AB SCIENCE
摘要:The present invention relates to a process for synthesizing in good yield substituted 2-aminoaryloxazole compounds of formula I which are useful as certain tyrosine kinase inhibitors and more particularly as c-kit, bcr-abl, Flt-3 and mutant forms thereof.

专利号:EP-3515880-B1
优先权日:2017-03-17
标题:Methods and compositions for synthesis of encoded libraries
发明人：LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN
权利人:HITGEN INC

专利号:US-2020149034-A1
优先权日:2017-03-17
标题:Methods and Compositions for Synthesis of Encoded Libraries

专利号:ES-2352320-T3
优先权日:2006-05-12
标题:NEW PROCEDURE FOR THE SYNTHESIS OF 2-AMINOXAZOL COMPOUNDS.

专利号:US-8916715-B2
优先权日:2011-06-20
标 题:Process for 4-methyloxazole-5-carboxamide
发明人：BONRATH WERNER; FISCHESSER JOCELYN; SHEN HONGYAN
权利人:BONRATH WERNER; FISCHESSER JOCELYN; SHEN HONGYAN; DSM IP ASSETS BV
摘要:A process for the preparation of 4-methyl-oxazole-5-carboxamide, an intermediate in the synthesis of pyridoxine, by reacting lower alkyl 4-methyl-oxazole-5-carboxy-late with a molar excess of anhydrous, liquid ammonia.

专利号:US-9763953-B2
优先权日:2005-09-22
标题:Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment
发明人：MAELICKE ALFRED
权利人:GALANTOS PHARMA GMBH; NEURODYN LIFE SCIENCES INC
摘要:The present invention refers to compounds that, in addition to enhancing the sensitivity to acetylcholine and choline, and their exogenous agonists, of neuronal cholinergic receptors and/or acting as cholinesterase inhibitors and/or neuroprotective agents, have enhanced blood-brain barrier permeability in comparison to their parent compounds. The compounds are derived (either formally by their chemical structure or directly by chemical synthesis) from natural compounds belonging to the class of amaryllidaceae alkaloids e.g., galantamine, narwedine and lycoramine, or from metabolites of said compounds. The compounds of the present invention can either interact as such with their target molecules, or they can act as “pro-drugsâ€?, in the sense that after reaching their target regions in the body they are converted by hydrolysis or enzymatic attack to the original parent compound and react as such with their target molecules, or both. The compounds of this invention may be used as medicaments.