CAS: 110860-92-9; 5,6-Dichloropyridin-3-Ol

该化合物是一种有机化合物,其特征为:环,是含有氮的由六人组成的芳香热循环,在2和3个位置存在两个氯原子,在5个位置存在一个氢氧基组,这是其独特的化学特性.该化合物一般在室温下是固体,由于氢氧化物组可以参与氢结合,极地溶剂中可能表现出中等溶解性.二氯替代品可影响其再活动,使其成为各种化学反应,包括核细胞替代的潜在候选物.此外,该化合物可能展示生物活动,这可能会引起药物研究的兴趣.其分子结构允许在农用化学品中或作为有机合成的中间体进行潜在应用.应参考安全数据,因为卤化化合物可能对环境和健康造成危害.

结构式图片

相似化合物

1196157-47-7 41288-96-4 52764-11-1

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CAS号110861-18-2 5-acetoxy-2,3-d... | CAS号98121-41-6 5, 6-二氯-3-氨基吡啶 | CAS号22353-40-8 5-硝基-2,3-二氯吡啶 | CAS号5418-51-9 2-羟基-5-硝基吡啶 | CAS号22353-38-4 5-硝基-2-羟基-3-氯吡啶 | CAS号74115-12-1 5-氯-3-羟基吡啶

合成工艺路线路线简述

    2-羟基-5-硝基吡啶置于喹啉,盐酸,氢氧化钾,Tetrafluoroboric Acid,Potassium Chlorate,铁粉,溶剂黄146,Sodium Nitrite,三氯氧磷体系中,用 水 用作溶剂,化学反应 6.75H,反应生成2,3-二氯-5-羟基吡啶
    参考文献:Chemistry Of 3-Hydroxypyridine Part 2: Synthesis Of 5,6-Dihalo-3-Hydroxypyridines
    标题:Chemistry Of 3-Hydroxypyridine Part 2: Synthesis Of 5,6-Dihalo-3-Hydroxypyridines
    摘要:本文介绍了从市售的 2-Hydroxy-5-Nitropyridine 开始,多步骤合成迄今未知的 5,6-二卤-3-羟基吡啶的方法.此外,还探讨了廉价的 2-氨基甲基呋喃(糠胺)在新颖的两步法中制备标题化合物的适用性.
    Doi:10.1055/s-1990-26919

    海关参考信息

    专利信息


    专利号:US-4756739-A
    优先权日:1985-12-21
    标题 :Pyridine derivatives and the N-oxides thereof, and the use thereof as intermediates for the synthesis of plant protecting agents
    发明人:FUSS ANDREAS; KOCH VOLKER
    权利人:HOECHST AG
    摘要:The compounds of the formula I (I) in which A denotes N or N->O, Z denotes O or NH, R denotes H, (halo)alkyl, (halo)alkenyl, (halo)alkynyl or alkoxycarbonyl, R1 denotes hydrogen, halogen, amino, -NHOH, hydroxyl, (substituted) phenylazo or a radical of the formulae Y=C=N-, Y1Y2C=N-, Y3NH- or K denotes 0 or 1, and m and n, independently of one another, denote a number from 1 to 4, with the proviso that, when Z-R denotes OH or NH2, (R1)n denotes at least one radical of the formula or represents two radicals, in the 5 or 6 position of the heterocyclic ring, which, in the 5 position, denote halogen and, in the 6 position, denote a radical of the group comprising halogen, amino, hydroxyl or phenylazo, which may be substituted as specified above, are valuable intermediates in the synthesis of plant protection agents.

    专利号:CN-101781245-A
    优先权日:2009-06-26
    标题 :A new method for the synthesis of substituted pyridine-3-carboxylic acids and analogues

    专利号:US-9751895-B2
    优先权日:2015-09-24
    标 题:N-[2-(2-amino-6,6-disubstituted-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)-1,3-thiazol-4-yl]amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; MIKOCHIK PETER JUSTIN; MURRAY JOHN CHARLES; HOU XINJUN
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n nand the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-9611264-B1
    优先权日:2015-09-24
    标 题:N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides
    发明人:BRODNEY MICHAEL AARON; BUTLER CHRISTOPHER RYAN; ZHANG LEI; O'NEILL BRIAN THOMAS; VERHOEST PATRICK ROBERT; SALOMON FERRER ROMELIA DEL CARMEN
    权利人:PFIZER
    摘要:The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, n n n n n n n n n n n n wherein the variables R 1 , R 2 and R 3 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.
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