CAS: 110-61-2; Succinonitrile

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CAS号110-15-6 琥珀酸； 丁二酸 | CAS号106-99-0 丁二烯 | CAS号764-42-1 反丁烯二腈 | CAS号286-75-9 1,5-Cyclo°Ctadi... | CAS号33695-47-5 2-phenylselanyl... | CAS号76-05-1 三氟乙酸(TFA) | CAS号68897-45-0 Methanaminium, ... | CAS号106-93-4 1,2-二溴乙烷 | CAS号17872-39-8 heptacyclo[6.6.... | CAS号75-05-8 乙腈 | CAS号407-59-0 1,1,1,4,4,4-六氟丁烷 | CAS号2366-01-0 2-bromo-1,1,1,4... | CAS号123-75-1 四氢吡咯 | CAS号110-60-1 1,4-丁二胺 | CAS号5724-81-2 1-pyrroline | CAS号32754-99-7 4-Aminobutyronitrile | CAS号123-56-8 丁二酰亚胺 | CAS号100-47-0 苯甲腈 | CAS号110-14-5 琥珀酰胺 | CAS号23923-29-7 2,2,3,3-tetrade...

丁二酸置于silicon Monophosphate 氨体系中,用 水 用作溶剂,化学反应 5.0H,以70%的收率获得丁二腈
参考文献:Method For Manufacturing Compounds Including Nitrile Functions
标题:Method For Manufacturing Compounds Including Nitrile Functions
摘要:描述了一种制备含有腈基团的化合物的方法,更具体地说,是含有两个腈基团的化合物,如丁二腈和己二腈.还描述了一种制备二腈化合物的方法,通过在硅正磷酸盐催化剂存在下,使氨与二羧基化合物的水溶液发生反应而获得.

专利信息

专利号:US-4918222-A
优先权日:1984-07-27
标 题 :Process for synthesis of N-acetylglycine
发明人：LIN JIANG-JEN; KNIFTON JOHN F; YEAKEY ERNEST L
权利人:TEXACO INC
摘要:An N-acetylglycine is manufactured by reacting paraformaldehyde with an acetamide and carbon monoxide in the present of a cobalt-containing catalyst promoted by a sulfoxide or dinitride compounds. The presence of sulfoxide or dinitrile ligands are essential for the high yield synthesis of N-acetylglycine and good cobalt recovery.

专利号:US-7897758-B2
优先权日:2005-04-27
标题 :Activators for oligonucleotide and phosphoramidite synthesis
发明人：WOLTER ANDREAS; LEUCK MICHAEL
权利人:SIGMA ALDRICH CO
摘要:The present invention discloses novel methods for the synthesis of oligonucleotides and nucleoside phosphoramidites. The methods are based on employing aryl-substituted 5-phenyl-1H-tetrazoles with perfluoroalkyl groups on the aromatic ring as activators. In one aspect the novel activators are used in the synthesis of oligonucleotides via the phosphoramidite approach. In this aspect the activators are highly efficient and can be applied with very short coupling times. In a further aspect, the activators of the invention are used in the synthesis of phosphoramidites through the reaction of nucleosides comprising a free hydroxyl group with phosphitylating agents. In this aspect the activators provide very pure phosphoramidites under mild conditions. The activators of the invention are further characterized by being highly soluble, non-hygroscopic and non-hazardous.

专利号:US-6337393-B1
优先权日:1997-11-13
标 题:Method and composition for chemical synthesis on an open environment support surface using high boiling point organic solvents to control evaporation
发明人：BRENNAN THOMAS M; FRAUENDORF ALBRECHT W
权利人:PROTOGENE LAB INC
摘要:A method for reducing evaporation of a liquid reagent solution during solid phase, micro-scale chemical synthesis of a molecule comprising sub-units on an open environment solid support surface. The method includes the steps of providing an open solid support surface including at least one binding site which is functionalized with a reactive chemical moiety; and depositing a substantially controlled and minute volume of liquid reagent solution onto the support surface, and in contact with the binding site. The reagent solution includes reactants contained in at least one relatively high boiling point solvent, in contrast to standard organic solvents for such reagents. Application of a high boiling point solvent substantially reduces evaporation of the reagent solution in the open environment during synthesis on the solid support while enabling the maintenance of a substantially high reaction yield.

专利号:US-9914746-B2
优先权日:2006-12-12
标题 :Oligonucleotides containing high concentrations of guanine monomers
发明人：SPROAT BRIAN STEPHEN
权利人:KUROS BIOSCIENCES AG
摘要:This invention pertains to methods for oligonucleotide synthesis, specifically the synthesis of oligonucleotides that contain a high content of guanine monomers. In more detail, the invention relates to a method for coupling a nucleoside phosphoramidite during the synthesis of an oligonucleotide to a universal support, to a first nucleoside, or to an extending oligonucleotide. The invention further relates to oligonucleotides obtainable by the methods of the invention.

专利号:US-3673250-A
优先权日:1970-12-01
标 题 :Catalytic hydration of nitriles to produce amides
发明人：RAUCH FRANCIS CLYDE; NACHTIGALL GUENTER WILLI
权利人:AMERICAN CYANAMID CO
摘要:Catalytic hydration of a nitrile with water in presence of a homogeneous catalyst in solution with the reactants, is described for the synthesis of an amide. The catalyst comprises two components, one a transition metal compound such as a rhodium compound, the other an organic phosphite, phosphine, arsenite, arsine, stibine or antimonite. One preferred example is rhodium trichloride with triphenyl phosphine as a catalyst for hydration of acrylonitrile to acrylamide. Some complexing of the solution components is suggested. In some embodiments, presence of a further component such as triphenyl phosphine oxide will improve the process.

专利号:EP-4556461-A1
优先权日:2023-11-16
标 题 :Process for the synthesis of salts with an organic anion useful as ionic conducting materials
发明人：KUNERT ROMAIN; BERNARD LAURENT; PICARD LIONEL
权利人:COMMISSARIAT ENERGIE ATOMIQUE
摘要:The present invention relates to a process for the preparation of a salt comprising an organic anion corresponding to a formula (I) comprising: M + , an alkali metal cation; R 1 , R 2 , R 3 , R 4 , independently, a radical chosen from: chlorine, anionic sulfonamide units of formula (IIa): R a -SO 2 -N - -, and anionic dinitrile units of formula (IIIa): CN-(R b ) - CN, with at least one of the radicals R 1 , R 2 , R 3 , R 4 being other than chlorine; said process comprising at least the step of contacting, in a solvent medium and in the presence of an alkali metal base, chloranil with at least one compound of formula (II) R a -SO 2 -NH 2 or (III) CN-R b -CN to form said salt comprising an organic anion of formula (I).