CAS: 104632-27-1; (6R)-6-N-Propyl-4,5,6,7-Tetrahydro-1,3-Benzothiazole-2,6-Diamine,Dihydrochloride
该化合物是在制药和生化方面;四氢化合物组的存在有助于其潜在的生物活动,而丙基亚基元素的子元素可能会影响其亲脂性和与生物目标的相互作用.六R表示的立体化学学表明,具体的空间安排可能会影响该化合物的再活动性和相互作用.
- 英文名称(6R)-6-N-Propyl-4,5,6,7-Tetrahydro-1,3-Benzothiazole-2,6-Diamine,Dihydrochloride
- 中文名称R-普拉克索盐酸盐
- IUPAC名称(R)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine dihydrochloride
- 其它别名2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydr°Chloride, (R)-
- CAS编号104632-27-1
- MFCD编号:MFCD09031317
- EINECS号:692-971-8
- FDA UNII编号:I9038PKO43
- 分子式:C10H18ClN3S分子量:247.79
- 产品CID: 85148
- 同类组份化合物CAS104632-27-1 (2HCl)104632-28-2 (free base)908244-04-2 (2HCl hydrate)
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
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C&L通报上下游产品
(R)-(+)-pramipexole (R)-4,5,6,7-tetrahydrobenzo[1,2-d]thiazole-2,6-diamine (+)-2-amino-6-propionamidotetrahydrobenzothiazole propyl tosylate合成工艺路线路线简述
📜(+)-(6R)-2,6-二氨基-4,5,6,7-四氢苯并噻唑,4-甲基苯磺酸丙酯置于4-甲基苯磺酸丙酯体系中,化学反应生成R-普拉克索盐酸盐
参考文献:Tetrahedron Asymmetry 2014,25,1239-1245
标题:Tetrahedron Asymmetry 2014,25,1239-1245
专利信息
专利号:WO-2011109596-A1
优先权日:2010-03-03
标 题 :Synthesis of chirally purified substituted benzothiazole diamines
专利号:EP-2542541-A1
优先权日:2010-03-03
标题 :Synthesis of chirally purified substituted benzothiazole diamines
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主要参考文献
1: Zhu J, Yu F. [Feeding difficulty and developmental delay for 8 months and nystagmus for 4 months in an infant]. Zhongguo Dang Dai Er Ke Za Zhi. 2017 Jan;19(1):68-72. Chinese. doi: 10.1016/j.ejphar.2016.06.035. Epub 2016 Jun 22. doi: 10.3233/JAD-150788. doi: 10.3390/pharmaceutics7040379.
5: Brust TF, Hayes MP, Roman DL, Watts VJ. New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling. Biochem Pharmacol. 2015 Jan 1;93(1):85-91. doi: 10.1016/j.bcp.2014.10.014. Epub 2014 Nov 7.
6: Collins GT, Jackson JA, Koek W, France CP. Effects of dopamine D(2)-like receptor agonists in mice trained to discriminate cocaine from saline: influence of feeding condition. Eur J Pharmacol. 2014 Apr 15;729:123-31. doi: 10.1016/j.ejphar.2014.02.014. Epub 2014 Feb 20.
合成参考文献
参考文献:10.1021/jm00386a009
摘要:Schneider CS, Mierau J. Dopamine autoreceptor agonists: resolution and pharmacological activity of 2,6-diaminotetrahydrobenzothiazole and an aminothiazole analogue of apomorphine. J Med Chem. 1987 Mar;30(3):494–8. doi: 10.1021/jm00386a009.
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