CAS: 71904-80-8; 2-(((Tert-Butoxycarbonyl)Amino)Methyl)Thiazole-4-Carboxylic Acid

上下游产品

bromopyruvic acid 2-(N-t-butoxycarbonylamino)thioacetamide tert-butyl dicarbonatedi-tert-butyl dicarbonate 2-(aminomethyl)thiazole-4-carboxylic acid hydr°Chloride (S)-1-((R)-2-Amino-3,3-diphenyl-propionyl)-pyrrolidine-2-carboxylic acid (4-cyano-thiazol-2-ylmethyl)-amide 2-((S)-1-{[2-((R)-1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-2-methyl-propyl)-thiazole-4-carbonyl]-amino}-ethyl)-5-methyl-oxazole-4-carboxylic acid pentafluorophenyl ester (S)-1-((S)-2-{(S)-2-[(2-{1-[(2-Aminomethyl-thiazole-4-carbonyl)-amino]-3-carbamoyl-propyl}-thiazole-4-carbonyl)-amino]-3-methyl-butyrylamino}-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester; compound with trifluoro-acetic acid (S)-1-[(S)-2-((S)-2-{[2-(1-{[2-(tert-Butoxycarbonylamino-methyl)-thiazole-4-carbonyl]-amino}-3-carbamoyl-propyl)-thiazole-4-carbonyl]-amino}-3-methyl-butyrylamino)-4-methyl-pentanoyl]-pyrrolidine-2-carboxylic acid 2,4,5-trichloro-phenyl ester

📜Boc-Gly-ocooet置于劳森试剂,2,6-二甲基吡啶,Lithium Hydroxide,Ammonium Hydroxide,Potassium Hydrogencarbonate,三氟乙酸酐体系中,用 四氢呋喃,甲醇,乙二醇二甲醚,二氯甲烷 作为反应溶剂,化学反应 36.25H,反应生成 2-[[(叔丁氧羰基)氨基]甲基]噻唑-4-羧酸
参考文献:Moody,Christopher J.; Bagley,Mark C.,Journal Of The Chemical Society. Perkin Transactions I,1998,# 3,P. 601-607
标题:Moody,Christopher J.; Bagley,Mark C.,Journal Of The Chemical Society. Perkin Transactions I,1998,# 3,P. 601-607

专利信息

专利号:US-2019031650-A1
优先权日:2016-01-29
标 题 :Dna alkylation and cross-linking agents as compounds and payloads for targeted therapies
发明人：HERZON SETH; HEALY ALAN; CRAWFORD JASON; VIZCAINO MARIA; NIKOLAYEVSKIY HERMAN
权利人:UNIV YALE
摘要:The present invention is directed to compounds related to precolibactin pharmaceutical compositions based upon these compounds and methods of synthesis which are employed to provide intermediates and final compounds, which are principally alkylating agents and anticancer compounds. The chemical synthetic approach disclosed facilitates the synthesis of numerous precolibactin analogs which can be used in the treatment of cancer.

专利号:WO-0127095-A1
优先权日:1999-10-14
标 题:Method for producing 2-(n-boc-aminomethyl)-thiazol-4-carboxylic acid
发明人：BUSCHMANN ERNST; PFEIFFER THOMAS
权利人:BASF AG; BUSCHMANN ERNST; PFEIFFER THOMAS
摘要:The synthesis of dolastatin 3, which inhibits cell growth, requires a 2-aminomethyl-thiazol-4-carboxylic acid that is protected on the amino group as a building block. The invention provides a synthesis for producing this compound with a high degree of purity and a high yield so that it is also feasible on an industrial scale. To this end, a glycine thioamide with a protective group on the amino group is reacted preferably with 3-brom-2-oxo-propionic acid in the presence of at least one tertiary amine.

专利号:US-2010113305-A1
优先权日:1999-03-22
标题:Oxazole and thiazole combinatorial libraries
发明人：MARTIN LENORE M; HU BI-HUANG
权利人:RHODE ISLAND EDUCATION
摘要:This invention provides a novel method for synthesizing an ensemble of peptides that allows for the generation of an unlimited number of antibiotic compounds. More specifically, the method comprises utilizes synthetic heterocyclic amino acids containing thaizole and/or oxazole as building blocks in a solid phase combinatorial synthesis to yield natural and unnatural antibiotic compounds.