CAS: 64840-90-0; 1-(4-Ethylphenyl)-2-Methyl-3-(Piperidin-1-yl)Propan-1-One
该化合物是一种合成有机化合物,其组成为丙酮骨架,由4-乙基苯组,甲基组和1-yl-mothy所替代.这一结构具有独特的物理化学特性,在制药和化学研究中具有价值.管状环的存在增强了其作为生物活性分子构件的潜力,特别是在CNS目标应用中.乙基苯组有助于亲脂性,影响溶性,并具有紧凑性.其明确界定的分子结构允许精确的修改,便利结构-活动关系研究.该化合物通常因其反应功能组而处于受控制的条件下处理,确保合成工作流程的稳定性和可复制性.
- 英文名称1-(4-Ethylphenyl)-2-Methyl-3-(Piperidin-1-yl)Propan-1-One
- 中文名称艾哌瑞松
- IUPAC名称1-(4-ethylphenyl)-2-methyl-3-(piperidin-1-yl)propan-1-one
- 其它别名Eperisone; 1-(4-Ethylphenyl)-2-Methyl-3-(1-Piperidyl)Propan-1-One; 4'-Ethyl-2-Methyl-3-Piperidinopropiophenone; 1-(4-Ethylphenyl)-2-Methyl-3-(1-Piperidinyl)-1-Propanon; 1-(4-Ethylphenyl)-2-Methyl-3-(1-Piperidinyl)-1-Propanone; 1-Propanone, 1-(4-Ethylphenyl)-2-Methyl-3-(1-Piperidinyl)-; 1-(4-Ethylphenyl)-2-Methyl-3-Piperidin-1-Yl-Propan-1-One; 1-(4-Ethylphenyl)-2-Methyl-3-Piperidin-1-Ylpropan-1-One
- CAS编号64840-90-0
- MFCD编号:MFCD00867679
- FDA UNII编号:2M2P0551D3
- 分子式:C17H25NO分子量:259.39
- 产品CID: 1631620
- 同类组份化合物CAS64840-90-0 (free base)56839-43-1 (HCl)
- 产品分类原料药 → 麻醉剂 → 骨骼肌松弛药
物理性质
MSDS等安全信息
- 警示词warning
- 危险描述H303 may be harmful by ingestion +H313 may be harmful by skin contact +h2413 may be harmful by inhalation
- 防范说明P264 wash thoroughly after treatmentp280 wear protective gloves / wear protective clothing / wear protective eye masks / wear protective masksp305 if in eyesp351 rinse carefully with water for a few minutesp338 remove contact lenses (if any) and easy to operate, continue rinsingp337 if eye irritation persistsp2393 get medical advice / care
- 安全声明H303 may be harmful by ingestion +h313 may be harmful by skin contact +h2413 may be harmful by inhalation
上下游产品
CAS号56839-43-1 盐酸乙哌立松合成工艺路线路线简述
📜盐酸乙哌立松置于碳酸氢钠,水,乙酸乙酯,Magnesium Sulfate体系中,用 乙酸乙酯 作为反应溶剂,以to Give 395 Mg (76% Yield) Of Racemic Eperisone Free Base As An Oil的收率获得产物艾哌瑞松
参考文献:Novel Forms Of Eperisone
标题:Novel Forms Of Eperisone
摘要:本发明涉及(2Rs)-1-(4-乙基苯基)-2-甲基-3-哌啶-1-基丙酮的新晶体形式.本发明根据各种实施方式描述了新晶体形式的制备和表征.本发明还涉及含有新晶体形式的药物组合物,该组合物可用于治疗和/或预防各种病症,如病理性肌肉挛缩,肌强直症和由各种神经病理状况引起的痉挛性麻痹或痉挛,并且还可用于治疗和/或预防各种类型的疼痛和病理性肌肉紧张.
海关参考信息
- 2902600000-乙苯
2912110000-甲醛
2912120000-乙醛
2912210000-苯甲醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-8859817-B2
优先权日:2011-01-13
标 题:Process for preparation of phenyl carbamate derivatives
发明人：CHOI YONG MOON
权利人:CHOI YONG MOON; BIO PHARM SOLUTIONS CO LTD
摘要:Provided are a process for the preparation of phenyl carbamate derivatives, useful in the treatment of CNS (central nervous system) disorders, an intermediate in the synthesis of the phenyl carbamate derivatives, and a process for preparation of the intermediate.
专利号:CN-109180606-A
优先权日:2018-09-30
标 题 :Synthesis of a class of optically active β-amino ketones
专利号:CN-118047664-A
优先权日:2024-01-30
标题 :A synthesis process of p-ethylpropiophenone intermediate based on continuous flow device
专利号:CN-109180606-B
优先权日:2018-09-30
标 题 :Synthesis method of beta-aminoketone with optical activity
专利号:CN-113603640-A
优先权日:2021-08-06
标题 :Synthesis method of pirenone ethylamine salt
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Park KH, Lee SC, Yuk JE, Kim SR, Lee JH, Park JW. Eperisone-Induced Anaphylaxis: Pharmacovigilance Data and Results of Allergy Testing. Allergy Asthma Immunol Res. 2019 Mar;11(2):231-240. doi: 10.4168/aair.2019.11.2.231.
2: Shin B, Yoon SY, Lee JH, Won HK, An J, Kang Y, Song WJ, Kim TB, Cho YS, Moon HB, Kwon HS. Clinical characteristics of eperisone-induced immediate-type hypersensitivity. Asian Pac J Allergy Immunol. 2020 Dec;38(4):279-285. doi: 10.12932/AP-211018-0420. 68(5):903-12. doi: 10.1016/j.pharep.2016.05.003. Epub 2016 Jun 29. 57(1):55-62. doi: 10.5414/CP203346.
12:221-228. doi: 10.2147/DHPS.S278467.
合成参考文献
参考文献:10.1007/bf00170885
摘要:Collin E, Frechilla D, Pohl M, Bourgoin S, Mauborgne A, Hamon M, Cesselin F. Differential effects of the novel analgesic, S 12813-4, on the spinal release of substance P- and calcitonin gene-related peptide-like materials in the rat. Naunyn Schmiedebergs Arch Pharmacol. 1994 Apr;349(4):387–93. doi: 10.1007/bf00170885.
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