CAS: 6296-53-3; N-(1,3-Dioxo-1,3-Dihydroisobenzofuran-4-yl)Acetamide

上下游产品

CAS号5434-20-8 3-氨基苯二甲酸 | CAS号108-24-7 乙酸酐 | CAS号603-11-2 3-硝基邻苯二甲酸 | CAS号641-70-3 3-硝基邻苯二甲酸酐 | CAS号105694-44-8 7-溴异苯并呋喃-1(3H)-酮 | CAS号105694-46-0 7-碘异苯并呋喃-1(3H)-酮 | CAS号608141-41-9 阿普斯特 | CAS号59434-19-4 4-氨基苯酞 | CAS号70097-45-9 7-氯-3H-1-异苯并呋喃酮 | CAS号102308-43-0 4-溴-2-苯并呋喃-1(3H)-酮 | CAS号13161-32-5 4-羟基异苯并呋喃-1(3H)-酮 | CAS号123573-16-0 N-(1,1-dimethyl... | CAS号4792-33-0 4-甲氧基异苯并呋喃-1(3H)-酮 | CAS号3883-64-5 7-氨基苯酞

3-硝基邻苯二甲酸酐置于乙酸酐,钯体系中,化学反应生成 1,3-二氧代-2-异吲哚啉乙酸
参考文献:Biniecki Et Al.,Annales Pharmaceutiques Francaises,1958,Vol. 16,P. 421,425
标题:Biniecki Et Al.,Annales Pharmaceutiques Francaises,1958,Vol. 16,P. 421,425

专利信息

专利号:WO-2016192694-A1
优先权日:2015-06-05
标 题 :A process for preparing the key intermediate of apremilast, using enzymatic resolution of the racemic amines
发明人：DOUBSKY JAN; KLVANA ROBERT; RICHTER JINDRICH; Lehnert Petr
权利人:ZENTIVA KS
摘要:The invention relates to a preparation method of (S)-l-(3-ethoxy-4-methoxyphenyl)- 2-(methylsulfonyl)-ethyl-amine (S)-l, or its N-acyl derivatives of general formula (S)-2. The amine (S)-l is the key intermediate in the synthesis of (S)-{2-[l-(3-ethoxy-4- methoxyphenyi)-2-methyisulfonylethyl]-4-acetylaminoisoindolin-l ?3-dione, known as Apremilast. In this synthesis, the amine (S)-l, or its respective salts, are subjected to condensation with 3-acetamidophthalic anhydride 4, providing the desired product 3 (Scheme 1).

专利号:US-8242310-B2
优先权日:2008-09-10
标题:Processes for the preparation of aminosulfone compounds
发明人：SAINDANE MANOHAR T; GE CHUANSHENG
权利人:SAINDANE MANOHAR T; GE CHUANSHENG; CELGENE CORP
摘要:Processes for synthesizing aminosulfone compounds are provided. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of isoindoline based PDE 4 modulators.

专利号:US-9688623-B2
优先权日:2012-02-21
标题:Processes for the preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine
发明人：VENKATESWARALU JASTI; RAJENDIRAN CHINNAPILLAI; REDDY NALLAMADDI RAVIKUMAR; CONNOLLY TERRENCE JOSEPH; RUCHELMAN ALEXANDER L; ECKERT JEFFREY; FRANK ANTHONY JOSEPH
权利人:CELGENE CORP
摘要:Provided herein are new processes for the preparation of aminosulfone intermediates for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for preventing or treating diseases or conditions related to an abnormally high level or activity of TNF-α. Further provided herein are processes for the commercial production of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.

专利号:US-3592810-A
优先权日:1967-06-16
标题:Process for the preparation of cephalosporin c intermediates
发明人：DOLFINI JOSEPH E
权利人:SQUIBB & SONS INC
摘要:THIS INVENTION RELATES TO THE CHEMICAL SYNTHESIS OF CEPHALOSPORIN C LACTONE BY A PROCESS THAT UTILIZES A NOVEL INTERMEDIATE HAVING THE FORMULA I 3-(R1-N(-R2)-C(-COO-R3)=CH-N-),4-(R4-S-CH2-)FURAN-2(3H)- ONE WHEREIN R1 AND R2 TOGETHER FORM A DIVALENT ACYL GROUP DERIVED FROM DICARBOXYLIC ACID; R3 IS ALKYL, ARYL, ARALKYL; AND R4 IS ACYL, ALKYL, OR ARALKYL; AND THE PROCESS OF PREPARATION THEREOF.

专利号:US-9126906-B2
优先权日:2012-02-21
标 题:Asymmetric synthetic processes for the preparation of aminosulfone compounds
发明人：CONNOLLY TERRENCE J; RUCHELMAN ALEXANDER L; LEONG WILLIAM W
权利人:CELGENE CORP
摘要:Processes for synthesizing aminosulfone compounds are provided. The processes provided herein utilize asymmetric reduction reactions, e.g., asymmetric hydrogenation, of protected or unprotected enamine or ketone substrates. Aminosulfone compounds obtained using methods provided herein are useful in production or synthesis of sulfone group containing isoindoline based compounds.

专利号:WO-2016202806-A1
优先权日:2015-06-15
标题:A novel synthetic pathway towards apremilast
发明人：STAVBER GAJ
权利人:LEK PHARMACEUTICALS
摘要:The present invention relates to a process for providing a chiral β-hydroxysulfone compound, an intermediate useful in the synthesis of the isoindoline-based compound apremilast.