CAS: 626-29-9; Myristic Anhydride

该化合物是一种源自甲状腺酸的脂肪酸酐,通常用作有机合成和工业应用的中间体,其主要优点包括作为乙酰剂的高度反应性,促进将本体类引入各种基体;该化合物在受控条件下具有良好稳定性,在诸如乙醚和氯仿等有机溶剂中可溶解,在实验室和生产环境中可提高其效用;在生产酯,表面活性剂和特殊化学品时,其长长的碳氢化合物链有助于形成所希望的疏水性;由于湿度敏感,需要妥善处理.

结构式图片

相似化合物

623-65-4 645-66-9 623-66-5

欧盟法规

REACH注册ECHA物质C&L通报REACH预注册

上下游产品

CAS号112-64-1 肉豆蔻酰氯 | CAS号544-63-8 肉豆蔻酸 | CAS号108-24-7 乙酸酐 | CAS号376-06-7 全氟十四酸 | CAS号30170-00-4 dimyristoyl pho... | CAS号544-63-8 肉豆蔻酸 | CAS号589-68-4 肉豆蔻酸单甘油酯

合成工艺路线路线简述

    📜肉豆蔻酸置于乙酸酐体系中,化学反应 0.5H,以98%的收率获得产物肉豆蔻酸酐
    参考文献:碳酸甘油酯有效,无溶剂,无溶剂合成1,3-Sn-甘油二酯
    标题:碳酸甘油酯有效,无溶剂,无溶剂合成1,3-Sn-甘油二酯
    摘要:描述了一种通过两步一锅法有效地无溶剂合成多种高纯度的1,3-Sn-甘油二酯(1,3-Sn-二酰基甘油)的方法.将碳酸甘油酯(4-羟甲基-1,3-二氧戊环-2-酮)与脂肪酸酐2A-D加热,可得到碳酸甘油酯脂肪酸酯3A-3D和相应脂肪酸的1:1混合物.在催化量的1,4-二氮杂双环[2.2.2]辛烷(dabco)存在下,于195-200oc下进一步加热反应混合物,可制得高纯度的1,3-Sn-甘油二酸酯4A-4D.
    DOI:10.1007/s11746-012-2165-0

    海关参考信息

    专利信息


    专利号:US-2009099061-A1
    优先权日:2006-01-27
    标 题:Synthesis of carotenoid analogs or derivatives with improved antioxidant characteristics
    发明人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
    权利人:FOSS BENTE J; NADOLSKI GEOFFRY T; LOCKWOOD SAMUEL F
    摘要:A method is described for synthesizing and administering carotenoid compounds with improved antioxidant characteristics. In some embodiments, extension or improvement of conjugation may be employed in structural modification of carotenoids. In other embodiments, reduction of ring/chain steric hindrance may improve the lambda max, and hence, the overall antioxidant capability, of particular compounds. In other embodiments, introduction and/or increase in synthetic handles for conjugation may improve the stoichiometric ratios of conjugating moieties to the polyene backbone. The methods may be used to improve natural and/or synthetic compounds for medicinal application in the treatment of disease.

    专利号:US-5137660-A
    优先权日:1991-03-15
    标题:Regioselective synthesis of 1,3-disubstituted glycerides
    发明人:MAZUR ADAM W; HILER II GEORGE D
    权利人:PROCTER & GAMBLE
    摘要:A process for the selective esterification of glycerol and 1-glyceryl derivatives to 1,3-disubstituted glycerides is disclosed. This process uses a water immiscible solvent, either a hydrocarbon or halogenated hydrocarbon, a 1,3-lipase and fatty acid anhydrides. This reaction mixture selectively esterifies the primary alcohol groups of glycerol or glycerol derivatives. The preferred derivatives of glycerol are alkyl ethers, alkyl phosphates, phospholipids, alkyl and diaklyl phosphates, and sugar glycosides.

    专利号:US-7344868-B2
    优先权日:2003-06-03
    标题:Method for synthesizing ceramide-type compounds
    发明人:LASSALLE LAURENT; YVERGNAUX FLORENT
    权利人:LASSALLE LAURENT; YVERGNAUX FLORENT
    摘要:The invention relates to the fields of fatty substance chemistry, specifically of the ceramide-type compound synthesis. The invention resides substantially in the synthesis of ceramide-type compounds. Specifically, the aim of the invention is a new enzymatic synthesis method, comprising at least one amidification step and one esterification step, achieved through lipases, among fatty acids and/or esters thereof and amino alcohols. The resulting ceramide-type compounds can be used as cosmetic and/or pharmaceutical compositions, in particular as dermatological compositions in conjunction or in admixture with one or more suitable cosmetic and/or pharmaceutical excipients or carriers. The method has an interest particularly in the synthesis of active compounds useful in the fields of cosmetology and/or pharmacology and specifically of dermatology.

    专利号:US-2012282652-A1
    优先权日:2011-02-28
    标题 :Preparation of peptide mixtures by protease catalysis designed to provide useful biological and physical properties
    发明人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU
    权利人:GROSS RICHARD A; VISWANATHAN KODANDARAMAN; QIN XU; POLITECHNIC INST UNIV NEW YORK
    摘要:A process for preparing unique peptide mixtures with a broad range of uses using combinations of natural and non-natural amino acid alkyl ester monomers and specific combinations of these monomers as dimers, trimers and higher oligomers selected from the large group of structural motifs that lead to useful physical and/or biological properties and that have been or may be identified from solid state peptide synthesis, isolation of peptides from natural sources, and production of peptides by recombinant DNA methods, or identification of peptides by recombinant methods such as phage display, the method of peptide synthesis comprising a) admixing one or more natural and non-natural amino acid alkyl ester monomer, dimer, trimer and higher oligomers with one or more proteases in a reaction medium; b) heating the mixture to between about 5° C. to about 90° C. for between 5 minutes and 24 hours; and c) recovering the formed oligopeptide.

    专利号:US-8183409-B2
    优先权日:2004-05-06
    标题:High yield and rapid synthesis methods for producing metallo-organic salts
    发明人:CHRISTGAU STEPHAN; ANDERSEN JENS E T
    权利人:CHRISTGAU STEPHAN; ANDERSEN JENS E T; OSTEOLOGIX AS
    摘要:A new method for preparing salts of metal cations and organic acids, especially divalent salts of alkaline earth metal ions from group II of the periodic system and carboxylic acids. The method comprising the use of a high temperature (about 90° or more) and, optionally. high pressure, in order to obtain a higher yield, purity and faster reaction speed than obtained with known synthesis methods. In particular, the present invention relates to the production of strontium salts of carboxylic acids. Novel strontium salts are also provided by the present method.

    专利号:US-9738678-B2
    优先权日:2007-07-09
    标 题 :Substituted nucleoside derivatives with antiviral and antimicrobial properties
    发明人:DONCEL GUSTAVO F; PARANG KEYKAVOUS; AGARWAL HITESH KUMAR
    权利人:EASTERN VIRGINIA MEDICAL SCHOOL; BOARD OF GOVERNORS FOR HIGHER EDUCATION STATE OF RHODE ISLAND AND PROVIDENCE PLANTATIONS
    摘要:The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: John Marshall, Et Al. Inhibition Of N-Methyl-D-Aspartate-Induced Retinal Neuronal Death By Polyarginine Peptides Is Linked To The Attenuation Of Stress-Induced Hyperpolarization Of The Inner Mitochondrial Membrane Potential. J Biol Chem. 2015 Sep 4;290(36):22030-48.
    [参考文献]: K M Patel, Et Al. A Convenient Synthesis Of Phosphatidylcholines: Acylation Of Sn-Glycero-3-Phosphocholine With Fatty Acid Anhydride And 4-Pyrrolidinopyridine. J Lipid Res. 1979 Jul;20(5):674-7.

    合成参考文献


    参考文献:10.1007/bf02533539
    摘要:Patel KM, Morrisett JD, Sparrow JT. The conversion of phosphatidylethanolamine into phosphatidylcholine labeled in the choline group using methyl lodide, 18‐crown‐6 and potassium carbonate. Lipids. 1979 Jun;14(6):596–7. doi: 10.1007/bf02533539.
    参考文献:10.1038/s44222-023-00082-0
    摘要:Couvreur P, Lepetre-Mouelhi S, Garbayo E, Blanco-Prieto MJ. Self-assembled lipid–prodrug nanoparticles. Nat Rev Bioeng. 2023 Jun 28;1(10):749–68. doi: 10.1038/s44222-023-00082-0.
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