CAS: 617-36-7; Ethyl 2-Amino-2-Oxoacetate

相似化合物

216959-34-1 471-47-6 598-42-5

上下游产品

Dimethyl oxalate ethanol 2-ethoxy-2-oxoacetic anhydride oxalic acid diethyl estertriphenylmethyl alcohol biphenyl ethyl cyanoformate p-tolyl-1H-imidazole-4,5-dione2-p-tolyl-1H-imidazole-4,5-dione

重氮乙酸乙酯置于叔丁基过氧化氢,碘化铵体系中,用 水,乙腈 作为反应溶剂,化学反应 12.0H,以65%的收率获得产物草酸酰胺乙酯
参考文献:重氮和nh4I的氧化偶联:反应生成伯草酸酯和α-酮酰胺的途径.
标题:重氮和nh4I的氧化偶联:反应生成伯草酸酯和α-酮酰胺的途径.
摘要:通过重氮化合物与nh4I的氧化偶合,已开发出一种简单有效的方法来制备伯草酸酯和α-酮酰胺.在优化的反应条件下,探索了一系列重氮酯和α-重氮酮,并以中等至非常好的收率获得了相应的产物.该协议不含金属,可在温和条件下执行,具有广泛的基材范围,并且操作简便.
DOI:10.1021/acs.Joc.9B02952

专利信息

专利号:WO-9946267-A1
优先权日:1998-03-12
标题 :Modulators of protein tyrosine phosphatases (ptpases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS; ONTOGEN CORP
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPases) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:US-6951878-B2
优先权日:1998-03-12
标 题:Benzo[b]thiophenyl or tetrahydro-benzo[b]thiophenyl modulators of protein tyrosine phosphatases (PTPases)
发明人：MOELLER NIELS PETER HUNDAHL; ANDERSEN HENRIK SUNE; IVERSEN LARS FOGH; OLSEN OLE HVILSTED; BRANNER SVEN; HOLSWORTH DANIEL DALE; BAKIR FARID; JUDGE LUKE MILBURN; AXE FRANK URBAN; JONES TODD KEVIN; RIPKA WILLIAM CHARLES; GE YU; UYEDA ROY TERUYUKI
权利人:NOVO NORDISK AS
摘要:The present invention provides novel compounds, novel compositions, methods of their use, and methods of their manufacture, where such compounds are pharmacologically useful inhibitors of Protein Tyrosine Phosphatases (PTPase's) such as PTP1B, CD45, SHP-1, SHP-2, PTPα, LAR and HePTP or the like. n The compounds are useful in the treatment of type I diabetes, type II diabetes, impaired glucose tolerance, insulin resistance, obesity, immune dysfunctions including autoimmunity diseases with dysfunctions of the coagulation system, allergic diseases including asthma, osteoporosis, proliferative disorders including cancer and psoriasis, diseases with decreased or increased synthesis or effects of growth hormone, diseases with decreased or increased synthesis of hormones or cytokines that regulate the release of/or response to growth hormone, diseases of the brain including Alzheimer's disease and schizophrenia, and infectious diseases.

专利号:EP-2038260-B1
优先权日:2006-06-16
标题:Stereoselective synthesis of (s)-1-methyl-3-phenylpiperazine
发明人：VAN VLIET MICHIEL CHRISTIAN ALEXANDER; KEMPERMAN GERARDUS JOHANNES; SCHREUDER GOEDHEIJT MARCEL
权利人:ORGANON NV
摘要:This invention provides for a compound according to Formula (1), wherein R1 is methyl, ethyl, n-propyl, isopropyl, benzyl or 2-haloethyl and the use thereof in a method to prepare (S)-1-methyl-3-phenylpiperazine by enzymatic hydrolysis of the compound, followed by separation and cleavage of the oxalamic groups, whereby the protease of Streptomyces griseus is used as enzyme for the enzymatic hydrolysis.

专利号:US-6416861-B1
优先权日:1999-02-16
标题 :Organosilicon compounds and uses thereof
发明人：LEE YOUNGHEE; SILVERMAN RICHARD B
权利人:UNIV NORTHWESTERN
摘要:A compound of the formula: n and a resin-bound compound of the formula: n and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 1 , P, Ar 1 , and X are as herein defined.

专利号:CN-117050134-A
优先权日:2022-05-05
标 题 :Synthesis of amide compounds and their uses

专利号:WO-2007144409-A1
优先权日:2006-06-16
标 题:Stereoselective synthesis of (s)-1-methyl-3-phenylpiperazine