CAS: 4775-82-0; (2S)-2-Amino-3-Ethoxypropanoic Acid

相似化合物

1562432-09-0 104839-00-1 1311380-50-3

上下游产品

N-Trt-Ser (R)-tert-butyl 1-ethoxy-3-hydroxypropan-2-ylcarbamate (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-ethoxypropanoic acid

📜N-Trt-Ser(Et)置于溶剂黄146体系中,用 乙醇 作为反应溶剂,化学反应 24.0H,以93%的收率获得产物o-乙氧基-L-丝氨酸盐酸盐
参考文献:N-三苯甲基-O-烷基-1-羟基氨基酸及其衍生物的便捷合成:在相关肽的合成中的应用
标题:N-三苯甲基-O-烷基-1-羟基氨基酸及其衍生物的便捷合成:在相关肽的合成中的应用
摘要:在咪唑存在下用nah原位制备的n-三苯甲基-羟基氨基酸2的二钠盐用烷基碘选择性地烷基化,得到n-三苯甲基-O-烷基-羟基氨基酸3.化合物3易于转化为o-烷基-羟基氨基酸5或用于掺入肽链的其他中间体.这些衍生物在相关肽的制备中的适用性通过脑啡肽n-碳苯甲氧基-酪氨酰-甘氨酰-甘氨酰-苯丙氨酰基-(o-乙基)丝氨酸苄基酯和n-碳苯甲氧基-酪氨酰-甘氨酰的保护类似物的合成来说明.-甘氨酰基-苯丙氨酰基-(o-甲基)高丝氨酸苄基酯.
DOI:10.1016/s0040-4020(01)88549-5

专利信息

专利号:US-7459443-B2
优先权日:1999-04-08
标 题 :Synthesis of biologically active compounds in cells
发明人：SERGEEV PAVEL
权利人:SERGEEV PAVEL
摘要:This invention relates to a new method of synthesis of biologically active substances of determined structure directly in the cells of living organisms containing specific RNA or DNA molecules of determined sequence. The method is based on the hybridization of two or more oligomers bound with biologically inactive precursors of biologically active substances to specific RNA or DNA in vivo in the cells of living organisms. After hybridization of the oligomers to RNA or DNA the biologically inactive precursors bound to the 5′ and/or 3′ ends of the oligomers can interact with each other to make biologically active form of the substances. This changing of properties is due to chemical reactions which bind the biologically inactive precursors through a chemical bond into a biologically active form of the whole compound.

专利号:US-2022243244-A1
优先权日:2019-10-10
标 题 :Compositions and methods for in vivo synthesis of unnatural polypeptides
发明人：ROMESBERG FLOYD E; FISCHER EMIL C; HASHIMOTO KOJI; FELDMAN AARON W; DIEN VIVIAN T; ZHANG YORKE
权利人:SCRIPPS RESEARCH INST
摘要:Disclosed herein are compositions, methods, and kits for a cell incorporating unnatural amino acids into an unnatural polypeptide. Also disclosed herein are compositions, methods, and kits for increasing activity and yield of the unnatural polypeptide synthesized by the cell.

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2005026143-A1
优先权日:1999-04-08
标 题:Synthesis of biologically active compounds in cells