CAS: 40186-71-8; 2,2',3,3',4,5',6,6'-Octachlorobiphenyl

该化合物是属于多氯联苯类的合成有机化合物,由两枚双联苯环组成,8个氯原子在不同位置上替换,大大改变了其物理和化学特性,其特点是高度稳定,低挥发性和耐降解性,使其在环境中具有持久性;由于其疏水性,该产品往往在活生物体脂肪组织中进行生物累积,从而产生潜在的毒性影响;该化合物一般色色色不色,为黄色,熔点很高;由于环境和健康方面的关切,许多国家已基本限制或禁止使用该化合物,特别是其作为内分泌干扰物的潜力及其与对人类和野生动物的各种不利健康影响的联系;适当处理和处置对于减轻其环境影响至关重要.

英文名称2,2',3,3',4,5',6,6'-Octachlorobiphenyl
中文名称2,2',3,3',4,5',6,6'-八氯联苯
IUPAC名称1,2,3,5-tetrachloro-4-(2,3,5,6-tetrachlorophenyl)benzene
其它别名2,2',3,3',4,5',6,6'-°Ctachlorobiphenyl
CAS编号40186-71-8
MFCD编号:MFCD00152685
FDA UNII编号:N731BPT821
分子式:C12H2Cl8分子量:429.77
产品CID: 1414542
产品分类分析化学 → 食品安全 → 二噁英，多氯联苯，呋喃

相似结构搜索
InChIKey: LJQOBQLZTUSEJA-UHFFFAOYSA-N
1S/C12H2Cl8/c13-3-1-6(16)11(19)12(20)7(3)8-9(17)4(14)2-5(15)10(8)18/h1-2H
计算化学: 氢键受体数*氢键供体数*可旋转键数1.0

MSDS等安全信息

危险描述Not Classified
Reported as not meeting GHS hazard criteria by 3 of 3 companies. For more detailed information, please visit ECHA C&L website.
安全声明The mechanism of action varies with the specific PCB. Dioxin-like PCBs bind to the aryl hydrocarbon receptor, which disrupts cell function by altering the transcription of genes, mainly be inducing the expression of hepatic Phase I and Phase II enzymes, especially of the cytochrome P450 family. Most of the toxic effects of PCBs are believed to be results of Ah receptor binding. Other PBCs are believed to interfere with calcium channels and/or change brain dopamine levels. PCBs can also cause endocrine disurption by altering the production of thyroid hormones and binding to estrogen receptors, which can stimulate the growth of certain cancer cells and produce other estrogenic effects, such as reproductive dysfunction. They will bioaccumulate by binding to receptor proteins such as uteroglobin. (A3, A4, A30, A66)

上下游产品

1,2,3,5-tetrachlorobenzene 2,3,5,6-tetrachloroaniline

合成工艺路线路线简述

📜1,2,3,5-四氯苯,2,3,5,6-四氯苯胺置于亚硝酸异戊酯体系中,化学反应生成 2,2',3,3',4,5',6,6'-八氯联苯
参考文献:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
标题:Physical,Spectral And Chromatographic Properties Of All 209 Individual Pcb Congeners
摘要:Physical,Spectral And Chromatographic Data For All 209 Individual Pcb Congeners Is Presented. The Individual Congeners Were Synthesized And Then Isolated And Purified. Recent Emphasis On The Source Of The Toxicity Of Commercial Pcb Formulations Has Increased The Need For A Complete Set Of The Pcb Congeners. Through The Use Of Two Capillary Gc Columns: 40% octadecyl/ 15% Phenyl Methyl Siloxane And 50% Phenyl Methyl Siloxane,It Was Possible To Separate 201 Pcb Congeners With Only Four Unresolved Pairs. The Data Compiled In This Study For All 209 Congeners Will Aid In The Identification Of Selected Individual Components Of These Environmental Pollutants. The Use Of This Data Also Presents The Opportunity For The Improved Quantification Of The Commercial Pcb Formulations.
DOI:10.1016/0045-6535(95)00140-4