CAS: 35035-05-3; Timepidium Bromide

该化合物是一种主要用作胃肠道紊乱治疗的聚氨酯溶液的抗胆碱基剂,它有选择性地抑制肌肉受体,从而减少消化道的肌肉萎缩.其主要优点包括采取有针对性的行动,与非选择性抗胆碱基相比,最大限度地减少系统性副作用.该化合物显示出快速发作和持续功效,适合管理肠胃炎综合症和功能性痢疾等条件.其精致的药理学特征可以确保可预测的吸收和代谢,有助于取得一致的治疗结果.

英文名称Timepidium Bromide
中文名称噻哌溴铵
IUPAC名称3-(di(thiophen-2-yl)methylene)-5-methoxy-1,1-dimethylpiperidin-1-ium bromide
其它别名Timepidium Bromide; Timepidium; 1,1-Dimethyl-5-Methoxy-3-(Dithien-2-Ylmethylene)Piperidinium Bromide; Mepidium; Piperidinium, 3-(Di-2-Thienylmethylene)-5-Methoxy-1,1-Dimethyl-, Bromide (9Ci); Sa 50Y; Sesden
CAS编号35035-05-3
MFCD编号:MFCD00865193
FDA UNII编号:8R9E4766V4
分子式:C17H22BrNOS2分子量:400.41
产品CID: 1355194
产品分类原料药 → 其它化学药

相似结构搜索
产品信息参考;;
InChIKey: QTSXMEPZSHLZFF-UHFFFAOYNA-M
InChI=1S/C17H22NOS2.BrH/c1-18(2)11-13(10-14(12-18)19-3)17(15-6-4-8-20-15)16-7-5-9-21-16;/h4-9,14H,10-12H2,1-3H3;1H/q+1;/p-1
计算化学: 氢键受体数4.0氢键供体数*可旋转键数3.0

物理性质

熔点198-200°
PSA:65.71
LogP:1.0694
溶解性Soluble In DMSO
储存条件储存在 -20°C
产品应用该化合物用作研究其对胃和二元血液流分布的影响;它导致胃血液总流量略有增加,而皮洛琴蚂蚁的肌肉血液流量显著增加.

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海关参考信息

2901210000-乙烯
2901220000-丙烯
2905122000-异丙醇
2922110001-单乙醇胺
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专利信息

专利号:US-2023271983-A1
优先权日:2020-07-29
标题 :Functionalized isonitriles and products, preparation and uses thereof
发明人：SOTELO PÃ‰REZ EDDY; AZUAJE GUERRERO JHONNY ALBERTO; MAJELLARO MARIA
权利人:UNIV SANTIAGO COMPOSTELA
摘要:The present invention relates to functionalized isonitrile compounds, formed by means of multicomponent environmentally friendly reactions, suitable for coupling to functional molecules such as biomolecules, APIs, chromophore and fluorophore molecules. The invention also relates to conjugates between said isonitrile compounds and functional molecules, which are useful in the synthesis of pharmaceutic drugs or tools, fluorescent molecules and labels, polymeric smart materials. The invention furthermore provides a kit for the in-vitro preparation of the functionalized isontrile compounds and conjugates. The invention also contemplates the medical use of said compounds and conjugates.

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合成参考文献

摘要:Gekkan Yakuji. Pharmaceuticals Monthly., 17(2087), 1975
摘要:Journal of Medicinal Chemistry., 15(914), 1972
摘要:Oyo Yakuri. Pharmacometrics., 23(461), 1982
参考文献:10.1007/bf00280120
摘要:Ohtsubo K, Fujii N, Higuchi S, Aoyama T, Goto I, Tatsuhara T. Influence of food on serum ambenonium concentration in patients with myasthenia gravis. European Journal of Clinical Pharmacology. 1992 Apr;42(4):371–4. doi: 10.1007/bf00280120.