CAS: 315183-21-2; N'-(3-Allyl-2-Hydroxybenzylidene)-2-(4-Benzylpiperazin-1-yl)Acetohydrazide

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CAS号24019-66-7 3-烯丙基-2-羟基苯甲醛 | CAS号24632-70-0 4-(苯甲基)-1-哌嗪乙酸

📜1-苄基-4-(乙氧基羰基甲基)哌嗪置于盐酸,肼体系中,用 甲醇,乙醇,水 作为反应溶剂,化学反应 1.5H,反应生成 4-(苯基甲基)-1-哌嗪乙酸 2-[[2-羟基-3-(2-烯丙-1-基)苯基]亚甲基]酰肼
参考文献:Wo2008/134474
标题:Wo2008/134474

专利信息

专利号:US-7022730-B2
优先权日:2001-10-19
标题:Bis-heteroaryl alkanes as therapeutic agents
发明人：MJALLI ADNAN M M; SHAHBAZ KATHY G J
权利人:TRANSTECH PHARMA INC
摘要:This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases in mammals mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.

专利号:US-8916705-B2
优先权日:2011-10-14
标 题:Procaspase-activating compounds and compositions
发明人：HERGENROTHER PAUL J
权利人:UNIV ILLINOIS; TRUSTEES OF THE UNIVERSITY OF ILLILNOIS BOARD OF
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:EP-4058432-A1
优先权日:2019-11-14
标 题:Improved synthesis of kras g12c inhibitor compound

专利号:US-9663482-B2
优先权日:2012-08-03
标 题:Substituted piperazinyl acetohydrazide procaspase-activating compounds
发明人：HERGENROTHER PAUL J; ROTH HOWARD S
权利人:UNIV ILLINOIS
摘要:The invention provides compounds and compositions useful for the modulation of certain enzymes. The compounds are of Formula I n nThe compounds and compositions can induce of cell death, particularly cancer cell death. The invention also provides methods for the synthesis and use of the compounds and compositions, including the use of compounds and compositions in therapy for the treatment of cancer and selective induction of apoptosis in cells.

专利号:US-2014315915-A1
优先权日:2009-02-09
标题:Design, synthesis and evaluation of procaspase activating compounds as personalized anti-cancer drugs

专利号:US-9522901-B2
优先权日:2005-05-26
标题:Compositions and methods including cell death inducers and procaspase activation
发明人：HERGENROTHER PAUL J; PUTT KARSON S; PETERSON QUINN P; FAKO VALERIE
权利人:UNIV ILLINOIS
摘要:Compositions and methods are disclosed in embodiments relating to induction of cell death such as in cancer cells. Compounds and related methods for synthesis and use thereof, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells are disclosed. Compounds are disclosed in connection with modification of procaspases such as procaspase-3. In embodiments, compositions are capable of activation of procaspase-3.