CAS: 25967-29-7; 7-Chloro-1-(Cyclopropylmethyl)-5-(2-Fluorophenyl)-3H-1,4-Benzodiazepin-2-One
- 英文名称7-Chloro-1-(Cyclopropylmethyl)-5-(2-Fluorophenyl)-3H-1,4-Benzodiazepin-2-One
- 中文名称氟托西泮
- IUPAC名称2H-1,4-Benzodiazepin-2-one, 7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro-
- 其它别名2H-1,4-Benzodiazepin-2-one,7-chloro-1-(cyclopropylmethyl)-5-(o-fluorophenyl)-1,3-dihydro- (8CI); 1-Cyclopropylmethyl-5-(o-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepine-2-one; Flutoprazepam; Restar; Restas
- CAS编号25967-29-7
- MFCD编号:MFCD00866972
- FDA UNII编号:2GHY1101MM
- 分子式:C19H16ClFN2O分子量:342.79
- 产品CID: 1226746
- 产品分类有机原料 → 有机杂环化合物 → 苯二氮卓类
物理性质
- 熔点118-122°
- 沸点539.3 °C at 760mmHg
- 闪点279.9 °C
- 密度1.37g/cm3
- pKa:1.93±0.35(预测)
- PSA:32.67
- LogP:3.5737
- 折射率1.661
- 蒸汽压1.07E-11mmHg at 25°C
- 溶解性DMF: 30 mg/mL; DMF:PBS(pH 7.2)(1:1): 0.5 mg/mL; DMSO: 25 mg/mL; Ethanol: 1 mg/mL
- 外观形态结晶性固体
- 储存条件Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
- 产品应用氟托西泮(25967-29-7)的的用途:该药是苯并二氮杂±嘁┪铩Ｗ饔没制和其他苯并二氮杂±嘁┪锵嗨疲但较持久,每日只需服用一次.用于神经症状如不安,紧张,抑郁,易疲劳及睡眠障碍,还用于心身疾病如高血压,慢性胃炎,过敏性大肠为症候群产生的不安,紧张,抑郁,易疲劳及睡眠障碍.
- 性质描述氟托西泮(25967-29-7)的性状:1.结晶,熔点118～122°C.2.急性毒性LD50雄,雌小鼠,雄,雌大鼠(mg/kg):2640,2430,13760,10060口服;2400,2110,2460,2230腹腔注射;全部＞5000皮下注射.
MSDS等安全信息
合成工艺路线路线简述
海关参考信息
- 2902300000-甲苯
2903919090-氯苯
2912110000-甲醛
2912120000-乙醛 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
专利信息
专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.
专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same
专利号:US-2016046560-A1
优先权日:2013-04-05
标题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:WO-2014165816-A1
优先权日:2013-04-05
标 题 :Compounds useful for the treatment of metabolic disorders and synthesis of the same
专利号:US-5466799-A
优先权日:1994-08-08
标 题:Synthesis of benzodiazepines
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Conti I, Sarati S, Caccia S. Propranolol does not alter flutoprazepam kinetics and metabolism in the rat. Eur J Drug Metab Pharmacokinet. 1991 Jan-Mar;16(1):53-8. Japanese. doi: 10.1002/14651858.CD008922.pub2. Review. Japanese. Japanese. Japanese.
合成参考文献
参考文献:10.1007/s00535-005-1687-8
摘要:Hojo M, Miwa H, Yokoyama T, Ohkusa T, Nagahara A, Kawabe M, Asaoka D, Izumi Y, Sato N. Treatment of functional dyspepsia with antianxiety or antidepressive agents: systematic review. J Gastroenterol. 2005 Nov;40(11):1036–42. doi: 10.1007/s00535-005-1687-8.
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