专利号:US-3933783-A 优先权日:1971-12-27 标 题 :Formation of peptide bonds in the presence of isonitriles 发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI 权利人:AJINOMOTO KK 摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.
专利号:US-3984417-A 优先权日:1971-12-27 标题:Method of producing active amino acid esters 发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI 权利人:AJINOMOTO KK 摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.
参考标题:Synthèse D'Analogues Structuraux De L'élédoïsine. 1RePartie: Préparation Des Produits Intermédiaires 作者:Ed. Sandrin,R. A. Boissonnas 摘要:The Preparation Of New Dipeptides And Tripeptides, Which Are Useful Intermediates In The Synthesis Of Eledoisin Analogues, Is Described.
合成参考文献
参考文献:10.1007/s11746-999-0082-7 摘要:Lee Y, Su M, Huang T, Shaw J. C‐terminal His‐tagging results in substrate specificity changes of the thioesterase I from Escherichia coli. J Americ Oil Chem Soc. 1999 Oct;76(10):1113–8. doi: 10.1007/s11746-999-0082-7.