CAS: 2578-84-9; Z-Phe-Onp

该化合物是一种属于氨酸衍生物类别的化学化合物,其主干体是氨基酸衍生物,是一种基本氨基酸,用苯氧基碳基(Pmc)保护组和4-硝基苯酯酯酸酸来修改,该组在标准实验室条件下一般稳定,但应谨慎处理,因为它的功能组具有潜在的再活动性,其应用范围扩大到生物化学研究以及药物开发,特别是在聚氨基药物合成中.

结构式图片

上下游产品

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合成工艺路线路线简述

    📜4-Nitrophenol Sodium Salt置于吡啶体系中,用 乙酸乙酯,苯 用作溶剂,化学反应生成N-苄氧羰基-L-苯丙氨酸对硝基苯酯
    参考文献:Wieland,T. Et Al.,Justus Liebigs Annalen Der Chemie,1962,Vol. 655,P. 189-194
    标题:Wieland,T. Et Al.,Justus Liebigs Annalen Der Chemie,1962,Vol. 655,P. 189-194

    海关参考信息

    专利信息


    专利号:US-3933783-A
    优先权日:1971-12-27
    标 题 :Formation of peptide bonds in the presence of isonitriles
    发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI
    权利人:AJINOMOTO KK
    摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

    专利号:US-3984417-A
    优先权日:1971-12-27
    标题:Method of producing active amino acid esters
    发明人:YASUDA NAOHIKO; ARIYOSHI YASUO; TOI KOJI
    权利人:AJINOMOTO KK
    摘要:Amino acids having masked amino groups react with amino acids having masked carboxyl groups to form peptide derivatives in good yields if the reaction medium contains an isonitrile. Isonitriles also are effective in causing condensation of amino acids having masked amino groups with compounds having active hydroxyl groups to the corresponding amino acid esters. The yields of the first-mentioned reaction are enhanced if the reaction mixture additionally contains one of the compounds having active hydroxyl groups. Both the peptide derivatives and the amino acid esters of the compounds having active hydroxyl groups are useful for peptide synthesis.

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    参考标题:Synthèse D'Analogues Structuraux De L'élédoïsine. 1RePartie: Préparation Des Produits Intermédiaires
    作者:Ed. Sandrin,R. A. Boissonnas
    摘要:The Preparation Of New Dipeptides And Tripeptides, Which Are Useful Intermediates In The Synthesis Of Eledoisin Analogues, Is Described.

    合成参考文献


    参考文献:10.1007/s11746-999-0082-7
    摘要:Lee Y, Su M, Huang T, Shaw J. C‐terminal His‐tagging results in substrate specificity changes of the thioesterase I from Escherichia coli. J Americ Oil Chem Soc. 1999 Oct;76(10):1113–8. doi: 10.1007/s11746-999-0082-7.
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